Genetic carrier and genetic susceptibility to disease (Z14-Z15)

ICD-10 codes Z14 through Z15 identify individuals who are carriers of certain genetic conditions or have a genetic susceptibility to specific diseases. These codes play a key role in documenting genetic risks for inherited disorders or predispositions, which may not yet cause symptoms but are important for medical management and family planning.

The Z14 category covers genetic carriers, including carriers of hemophilia A (both symptomatic and asymptomatic), cystic fibrosis, and a wide range of other inherited conditions such as muscular dystrophy, fragile X syndrome, and various metabolic and neurogenetic disorders. For example, someone identified as a hemophilia carrier (Z14.0) or a cystic fibrosis carrier (Z14.1) will have their carrier status documented for clinical awareness. Meanwhile, the Z15 codes indicate genetic susceptibility to diseases like malignant neoplasms (cancers), epilepsy, obesity, and other conditions. Subcodes such as Z15.01 specify genetic risks for breast cancer linked to BRCA1 or BRCA2 mutations, while Z15.81 addresses susceptibility to multiple endocrine neoplasia. Using these codes helps healthcare providers identify at-risk individuals for personalized monitoring and preventive care based on their hereditary profiles.