2026 ICD-10-CM Diagnosis Code A00Cholera

ICD-10-CM CodesA00–B99A00-A09A00

ICD-10-CM A00
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

A00 is a non-billable ICD-10-CM category code for cholera, so it cannot be submitted on claims. Use a more specific code from this category instead, such as A00.0, A00.1, and A00.9.

Code Identity

ICD-10-CM Code
A00
Billable Status
No — Non-Billable Category
Code Describes
Cholera
Chapter
A00-A09
Intestinal infectious diseases

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionA00-A09Intestinal infectious diseases
CategoryA00Cholera
This CodeA00Cholera

Specific Coding for CholeraOverview

Non-specific codes like A00 require more characters. Use one of these billable codes instead:

  • Use A00.0 for Cholera due to Vibrio cholerae 01, biovar cholerae

  • Use A00.1 for Cholera due to Vibrio cholerae 01, biovar eltor

  • Use A00.9 for Cholera, unspecified

Clinical InformationClinical

  • Cholera

    an acute diarrheal disease endemic in india and southeast asia whose causative agent is vibrio cholerae. this condition can lead to severe dehydration in a matter of hours unless quickly treated.
  • Cholera Morbus

    an old term that is no longer used in the scientific literature. cholera morbus refers to acute gastroenteritis occurring in summer or autumn; characterized by severe cramps, diarrhea, and vomiting.
  • Cholera Toxin

    an enterotoxin from vibrio cholerae. it consists of two major protomers, the heavy (h) or a subunit and the b protomer which consists of 5 light (l) or b subunits. the catalytic a subunit is proteolytically cleaved into fragments a1 and a2. the a1 fragment is a mono(adp-ribose) transferase. the b protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the a1 fragment. the a1 catalyzed transfer of adp-ribose to the alpha subunits of heterotrimeric g proteins activates the production of cyclic amp. increased levels of cyclic amp are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
  • Cholera Vaccines

    vaccines or candidate vaccines used to prevent infection with vibrio cholerae. the original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.
  • Classical Swine Fever

    an acute, highly contagious disease affecting swine of all ages and caused by the classical swine fever virus. it has a sudden onset with high morbidity and mortality.
  • Classical Swine Fever Virus

    a species of the pestivirus genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
  • Gastrointestinal Diseases

    diseases in any segment of the gastrointestinal tract from esophagus to rectum.
  • Vipoma

    a tumor that secretes vasoactive intestinal peptide, a neuropeptide that causes vasodilation; relaxation of smooth muscles; watery diarrhea; hypokalemia; and hypochlorhydria. vipomas, derived from the pancreatic islet cells, generally are malignant and can secrete other hormones. in most cases, vipomas are located in the pancreas but can be found in extrapancreatic sites.
  • Vibrio cholerae

    the etiologic agent of cholera.
  • Gastroenteritis

    inflammation of any segment of the gastrointestinal tract from esophagus to rectum. causes of gastroenteritis are many including genetic, infection, hypersensitivity, drug effects, and cancer.
  • Pestivirus

    a genus of flaviviridae, also known as mucosal disease virus group, which is not arthropod-borne. transmission is by direct and indirect contact, and by transplacental and congenital transmission. species include border disease virus, bovine viral diarrhea virus (diarrhea virus, bovine viral), and classical swine fever virus.
  • Cholera

    an acute diarrheal illness caused by consuming water or food contaminated by the bacterium vibrio cholerae. adequate rehydration is key to surviving this illness.
  • Cholera Toxin

    secreted by vibrio cholerae, cholera toxin is a natural bacterial enterotoxin consisting of major components heavy a- and light b peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. b peptide anchors the protein to epithelia; a peptide enters the cytoplasm and activates adenylate cyclase. due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (nci04)
  • Cholera Toxin B Subunit IgG Antibody Measurement|CTBIGGAB|Cholera Toxin B Subunit IgG Antibody|Cholera Toxin B Subunit IgG Antibody

    the determination of the amount of cholera toxin b subunit igg antibody present in a sample.
  • Cholera Toxin B Subunit|CTB|VIBRIO CHOLERA TOXIN B SUBUNIT

    the approximately 55 kda, receptor binding b subunit of the cholera toxin and the virulence factor for vibrio cholerae.
  • Salmonella enterica Serotype choleraesuis var. decatur|SALMONELLA CHOLERAESUIS VAR. DECATUR|Salmonella decatur

    a gram-negative, rod-shaped serotype of the bacteria genus salmonella, species salmonella enterica, subspecies enterica. salmonella decatur, a rare human pathogen, was formerly classified as serotype choleraesuis variant decatur.
  • Salmonella Serotype Choleraesuis|SALMONELLA SEROTYPE CHOLERAESUIS|Salmonella enterica subsp. enterica serovar Choleraesuis

    any bacterial organism that can be assigned to the genus salmonella with serotype choleraesuis.
  • Vibrio cholerae DNA Measurement|VCHDNA|Vibrio cholerae DNA|Vibrio cholerae DNA

    the determination of the amount of vibrio cholerae dna present in a sample.
  • Vibrio cholerae, Vibrio parahaemolyticus, and/or Vibrio vulnificus DNA Measurement|C166008|V. chol/parahaemolyticus/vulnificus DNA|V. chol/parahaemolyticus/vulnificus DNA|Vibrio cholerae/parahaemolyticus/vulnificus DNA

    the determination of the amount of vibrio cholerae, vibrio parahaemolyticus, and/or vibrio vulnificus dna present in a sample.
  • Vibrio cholerae|VIBRIO CHOLERAE|Vibrio comma|Vibrio comma

    a species of facultatively anaerobic, gram negative, curved rod shaped bacteria assigned to the phylum proteobacteria. this species is motile, oxidase and lipase positive, can use a wide variety of sugars as carbon sources, does not require salt for growth, and produces cholera toxin. v. cholerae is the causative agent of cholera.
  • Vibrio mimicus|Sucrose Negative Vibrio cholerae|VIBRIO MIMICUS

    a species of facultatively anaerobic, gram negative, curved rod shaped bacteria assigned to the phylum proteobacteria. this species is motile, oxidase positive, lipase negative, hemolytic, cannot use sucrose as a carbon source and does not require salt for growth. v. mimicus is a found in marine and fresh water environments and is a pathogen that causes gastroenteritis.
  • WDHA Syndrome|Islet Cell WDHA Syndrome|Pancreatic Cholera|Pancreatic WDHA Syndrome|Verner Morrison Syndrome|WDHH|Watery Diarrhea Syndrome|Watery Diarrhea with Hypokalemic Alkalosis|Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome

    a rare syndrome characterized by severe watery diarrhea, hypokalemia, and achlorhydria. it is caused by the oversecretion of vasoactive intestinal peptide from the pancreatic islet cells.
  • Cholera Toxin B Subunit IgG Antibody Measurement

    the determination of the amount of cholera toxin b subunit igg antibody present in a sample.

Patient EducationClinical

Cholera

Cholera is a bacterial infection that causes diarrhea. The cholera bacterium is usually found in water or food that has been contaminated by feces (poop). Cholera is rare in the US. You may get it if you travel to parts of the world with poor water and sewage treatment. Outbreaks can also happen after disasters.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About A00Overview

Is A00 (Cholera) a billable code?

No. This is a category header that groups the codes for cholera, and headers cannot be submitted on claims. Claims for cholera need a more specific code from this category, such as A00.0, A00.1, and A00.9.