ICD-10-CM Code A00


Version 2020 Non-Billable Code

Not Valid for Submission

A00 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of cholera. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

Short Description:Cholera
Long Description:Cholera

Consider the following ICD-10 codes with a higher level of specificity:

  • A00.0 - Cholera due to Vibrio cholerae 01, biovar cholerae
  • A00.1 - Cholera due to Vibrio cholerae 01, biovar eltor
  • A00.9 - ... unspecified

Clinical Information

  • CHOLERA-. an acute diarrheal disease endemic in india and southeast asia whose causative agent is vibrio cholerae. this condition can lead to severe dehydration in a matter of hours unless quickly treated.
  • CHOLERA TOXIN-. an enterotoxin from vibrio cholerae. it consists of two major protomers the heavy h or a subunit and the b protomer which consists of 5 light l or b subunits. the catalytic a subunit is proteolytically cleaved into fragments a1 and a2. the a1 fragment is a monoadp ribose transferase. the b protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the a1 fragment. the a1 catalyzed transfer of adp ribose to the alpha subunits of heterotrimeric g proteins activates the production of cyclic amp. increased levels of cyclic amp are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
  • VIPOMA-. a tumor that secretes vasoactive intestinal peptide a neuropeptide that causes vasodilation; relaxation of smooth muscles; watery diarrhea; hypokalemia; and hypochlorhydria. vipomas derived from the pancreatic islet cells generally are malignant and can secrete other hormones. in most cases vipomas are located in the pancreas but can be found in extrapancreatic sites.
  • GASTROINTESTINAL DISEASES-. diseases in any segment of the gastrointestinal tract from esophagus to rectum.
  • CLASSICAL SWINE FEVER-. an acute highly contagious disease affecting swine of all ages and caused by the classical swine fever virus. it has a sudden onset with high morbidity and mortality.
  • CLASSICAL SWINE FEVER VIRUS-. a species of the pestivirus genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
  • CHOLERA MORBUS-. an old term that is no longer used in the scientific literature. cholera morbus refers to acute gastroenteritis occurring in summer or autumn; characterized by severe cramps diarrhea and vomiting.
  • CHOLERA VACCINES-. vaccines or candidate vaccines used to prevent infection with vibrio cholerae. the original cholera vaccine consisted of killed bacteria but other kinds of vaccines now exist.

Code Classification

  • Certain infectious and parasitic diseases (A00–B99)
    • Intestinal infectious diseases (A00-A09)
      • Cholera (A00)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Cholera is a bacterial infection that causes diarrhea. The cholera bacterium is usually found in water or food that has been contaminated by feces (poop). Cholera is rare in the US. You may get it if you travel to parts of the world with poor water and sewage treatment. Outbreaks can also happen after disasters. The disease is not likely to spread directly from person to person.

Cholera infections are often mild. Some people don't have any symptoms. If you do get symptoms, they usually start 2 to 3 days after infection. The most common symptom is watery diarrhea.

In some cases, the infection can be severe, causing lots of watery diarrhea, vomiting, and leg cramps. Because you quickly lose body fluids, you are at risk for dehydration and shock. Without treatment, you could die within hours. If you think that you might have cholera, you should get medical care right away.

Doctors diagnose cholera with a stool sample or rectal swab. Treatment is the replacement of the fluid and salts that you lost through the diarrhea. This is usually with a rehydration solution that you drink. People with severe cases may need an I.V. to replace the fluids. Some of them may also need antibiotics. Most people who get fluid replacement right away will recover.

There are vaccines to prevent cholera. One of them is available for adults in the U.S. Very few Americans need it, because most people do not visit areas that have an active cholera outbreak.

There are also simple steps you can take to help to prevent cholera infection:

  • Use only bottled or purified water for drinking, washing dishes, making ice cubes, and brushing your teeth
  • If you do use tap water, boil it or use iodine tablets
  • Wash your hands often with soap and clean water
  • Make sure that the cooked food you eat is fully cooked and served hot
  • Avoid unwashed or unpeeled raw fruits and vegetables

Centers for Disease Control and Prevention

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