Genetic susceptibility to disease (Z15) ICD-10-CM
The Z15 code range covers genetic susceptibility to disease with 18 ICD-10-CM diagnosis codes. 14 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- confirmed abnormal gene
Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the Z15 Range 18 codes · 14 billable
- Z15 Genetic susceptibility to diseaseNon-billable
- Z15.0 Genetic susceptibility to malignant neoplasmNon-billable
- Z15.01 Genetic susceptibility to malignant neoplasm of breast
- Z15.02 Genetic susceptibility to malignant neoplasm of ovary
- Z15.03 Genetic susceptibility to malignant neoplasm of prostate
- Z15.04 Genetic susceptibility to malignant neoplasm of endometrium
- Z15.05 Genetic susceptibility to malignant neoplasm of fallopian tube(s)
- Z15.06 Genetic susceptibility to malignant neoplasm of digestive systemNon-billable
- Z15.060 Genetic susceptibility to colorectal cancer
- Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system
- Z15.07 Genetic susceptibility to malignant neoplasm of urinary tract
- Z15.09 Genetic susceptibility to other malignant neoplasm
- Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders
- Z15.2 Genetic susceptibility to obesity
- Z15.3 Genetic susceptibility to kidney disease
- Z15.8 Genetic susceptibility to other diseaseNon-billable
- Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN]
- Z15.89 Genetic susceptibility to other disease
About the Z15 Code Range
Genetic susceptibility means a predisposition to disease. Here, it relates to cancer, epilepsy and neurodevelopmental disorders, obesity, kidney disease, and other diseases.
Z15.0 groups cancer susceptibility by the affected site, including the breast, ovary, prostate, endometrium, fallopian tubes, digestive system, and urinary tract. Within the digestive system, Z15.06 separates colorectal cancer from other cancers. Separate subdivisions cover epilepsy and neurodevelopmental disorders, obesity, and kidney disease. Z15.8 covers susceptibility to other diseases, with a separate subdivision for multiple endocrine neoplasia.
Questions About This Page
How many billable codes are in the Z15 range?
Of the 18 codes in this range, 14 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the Z15 range classify?
The range classifies genetic susceptibility to disease. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
