2026 ICD-10-CM Diagnosis Code Z15.060Genetic susceptibility to colorectal cancer

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15.060
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15.060 is a billable ICD-10-CM diagnosis code for genetic susceptibility to colorectal cancer. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting.

Code Identity

ICD-10-CM Code
Z15.060
Billable Status
Yes — Valid for Submission
Code Describes
Genetic susceptibility to colorectal cancer
Short Description
Genetic susceptibility to colorectal cancer
Same as the full description in the CMS dataset.
Parent Code
Z15.06
Genetic susceptibility to malignant neoplasm of digestive system

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15.060Genetic susceptibility to colorectal cancer

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z15.060.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z15.060 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Genetic
      • susceptibility to disease NEC
        • malignant neoplasm
          • colorectal

Code History & ChangesHistory

New Code Z15.060 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.

Replacement Z15.060 replaces the following previously assigned code(s):

  • Z15.09 - Genetic susceptibility to other malignant neoplasm
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About Z15.060Overview

Is Z15.060 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic susceptibility to colorectal cancer on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z15.060 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because genetic susceptibility to colorectal cancer describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z15.060 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for genetic susceptibility to colorectal cancer on inpatient claims.