2027 ICD-10-CM Diagnosis Code P58.42Neonatal jaundice due to drugs or toxins given to newborn

ICD-10-CM Codes›P00–P96›P50-P61›P58

ICD-10-CM P58.42
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

P58.42 is a billable ICD-10-CM diagnosis code for neonatal jaundice due to drugs or toxins given to newborn. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 794. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Hemolytic jaundice and perinatal jaundice.

Code Identity

ICD-10-CM Code
P58.42
Billable Status
Yes — Valid for Submission
Code Describes
Neonatal jaundice due to drugs or toxins given to newborn
Short Description
Neonatal jaundice due to drugs or toxins given to newborn
Same as the full description in the CMS dataset.
Parent Code
P58.4
Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn

Code Classification

ChapterP00–P96Certain conditions originating in the perinatal period
SectionP50-P61Hemorrhagic and hematological disorders of newborn
CategoryP58Neonatal jaundice due to other excessive hemolysis
This CodeP58.42Neonatal jaundice due to drugs or toxins given to newborn

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to P58.42: its own notes plus those printed at P58.4, P58, block P50-P61, and Chapter 16. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • conditions that have their origin in the fetal or perinatal period (before birth through the first 28 days after birth) even if morbidity occurs later

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From P58 Neonatal jaundice due to other excessive hemolysis applies to 9 codes
  • jaundice due to isoimmunization (P55-P57)
From Block P50-P61 Hemorrhagic and hematological disorders of newborn applies to 67 codes
  • congenital stenosis and stricture of bile ducts (Q44.3)
  • Crigler-Najjar syndrome (E80.5)
  • Dubin-Johnson syndrome (E80.6)
  • Gilbert syndrome (E80.4)
  • hereditary hemolytic anemias (D55-D58)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • tetanus neonatorum (A33)

Code First

The underlying condition named in the note is sequenced before this code.

From P58.4 Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn applies to 2 codes
  • poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From P58.4 Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn applies to 2 codes
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Notes

General instructions on how these codes are used.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • Codes from this chapter are for use on newborn records only, never on maternal records

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name P58.42, its category, or a range that includes it.

Excludes1 3

These codes carry an Excludes1 note naming P58.42: they are not reported together with it, unless the two conditions are unrelated.

  • P93 Reactions and intoxications due to drugs administered to newborn
    jaundice due to drugs or toxins transmitted from mother or given to newborn (P58.4-) names P58.4-, which includes this code
  • K72 Hepatic failure, not elsewhere classified
    icterus of newborn (P55-P59) names P55-P59, which includes this code
  • R17 Unspecified jaundice
    neonatal jaundice (P55, P57-P59) names P57-P59, which includes this code

Excludes2 2

These codes carry an Excludes2 note naming P58.42: its condition is not part of those codes, and both may be reported when the patient has both.

  • P04 Newborn affected by noxious substances transmitted via placenta or breast milk
    neonatal jaundice from excessive hemolysis due to drugs or toxins transmitted from mother (P58.4) names P58.4, which includes this code
  • Block R70-R79 Abnormal findings on examination of blood, without diagnosis
    hemorrhagic and hematological disorders of newborn (P50-P61) names P50-P61, which includes this code

Code Also 1

These codes say P58.42 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • K76.82 Hepatic encephalopathy
    icterus of newborn (P55-P59) names P55-P59, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR PNL007
Hemolytic jaundice and perinatal jaundice
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Jaundice

Jaundice causes your skin and the whites of your eyes to turn yellow. Too much bilirubin causes jaundice. Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert P58.42 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
774.1 Perinat jaund:hemolysis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About P58.42Overview

What is the ICD-10 code for neonatal jaundice due to drugs or toxins given to newborn?

The ICD-10-CM code for neonatal jaundice due to drugs or toxins given to newborn is P58.42 (sometimes written as P5842). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is P58.42 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neonatal jaundice due to drugs or toxins given to newborn on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does P58.42 group to?

When neonatal jaundice due to drugs or toxins given to newborn is the principal diagnosis on an inpatient stay, it groups to MS-DRG 794 (neonate with Other Significant Problems), which carries a relative weight of 1.4934. Higher weights mean higher Medicare reimbursement.

Can P58.42 be reported with Q44.3?

Not as a rule. The Excludes1 note at block P50-P61, which applies to P58.42, lists "congenital stenosis and stricture of bile ducts (Q44.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does P58.42 need an additional code?

When the condition applies, yes. The Use Additional Code note at P58.4, which applies to P58.42, reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after P58.42.