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  5. Neonatal jaundice from other and unspecified causes (P59)

Neonatal jaundice from other and unspecified causes (P59)

ICD-10 code P59 covers neonatal jaundice caused by a variety of other and unspecified reasons, differentiating it from common types of newborn jaundice. It includes specific conditions such as jaundice after preterm birth, inspissated bile syndrome, and jaundice linked to hepatocellular damage or breast milk inhibitors.

The ICD-10 code for neonatal jaundice includes several detailed subcodes. For example, P59.0 describes jaundice specifically associated with preterm delivery, often called "neonatal jaundice due to delayed conjugation." P59.1 identifies inspissated bile syndrome, a condition also known as extrahepatic obstructive biliary disease. Codes like P59.20 and P59.29 address jaundice from unspecified or infectious liver damage, often referred to as neonatal hepatitis or perinatal liver disorders. Breast milk–related jaundice is classified under P59.3. Other specified causes, including metabolic diseases or genetic conditions such as Crigler-Najjar syndrome, fall under P59.8. When the cause is unknown, P59.9 is used, encompassing terms like physiological jaundice and various types of hyperbilirubinemia. This coding system helps clinicians and coders accurately capture the diverse origins of neonatal jaundice for treatment and billing purposes.

Instructional Notations

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • jaundice due to inborn errors of metabolism E70 E88
  • kernicterus P57

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Crigler-Najjar Syndrome

A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.

Gilbert Disease

A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.

Hyperbilirubinemia

A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.

Hyperbilirubinemia, Hereditary

Inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.

Hyperbilirubinemia, Neonatal

Accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin.

Jaundice

A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

Jaundice, Chronic Idiopathic

A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.

Jaundice, Neonatal

Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.

Jaundice, Obstructive

Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.

Weil Disease

A severe form of LEPTOSPIROSIS, usually caused by LEPTOSPIRA INTERROGANS SEROVAR ICTEROHAEMORRHAGIAE and occasionally other serovars. It is transmitted to humans by the rat and is characterized by hemorrhagic and renal symptoms with accompanying JAUNDICE.