2027 ICD-10-CM Diagnosis Code T65Toxic effect of other and unspecified substances

ICD-10-CM Codes›S00–T88›T51-T65›T65

ICD-10-CM T65
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T65 is a non-billable ICD-10-CM category code for toxic effect of other and unspecified substances, so it cannot be submitted on claims. Use a more specific code from this category instead, such as T65.0X1A, T65.0X1D, T65.0X1S, and T65.0X2A.

Code Identity

ICD-10-CM Code
T65
Billable Status
No — Non-Billable Category
Code Describes
Toxic effect of other and unspecified substances
Short Description
Toxic effect of other and unspecified substances
Same as the full description in the CMS dataset.
Chapter
T51-T65
Toxic effects of substances chiefly nonmedicinal as to source

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT51-T65Toxic effects of substances chiefly nonmedicinal as to source
CategoryT65Toxic effect of other and unspecified substances
This CodeT65Toxic effect of other and unspecified substances

Specific Coding for Toxic effect of other and unspecified substancesOverview

Non-specific codes like T65 require more characters. Use one of these billable codes instead:

  • T65.0 for Toxic effect of cyanides

  • T65.0X for Toxic effect of cyanides

  • T65.1 for Toxic effect of strychnine and its salts

  • T65.1X for Toxic effect of strychnine and its salts

  • T65.2 for Toxic effect of tobacco and nicotine

  • T65.21 for Toxic effect of chewing tobacco

  • T65.22 for Toxic effect of tobacco cigarettes

  • T65.29 for Toxic effect of other tobacco and nicotine

  • T65.3 for Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues

  • T65.3X for Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues

  • T65.4 for Toxic effect of carbon disulfide

  • T65.4X for Toxic effect of carbon disulfide

  • T65.5 for Toxic effect of nitroglycerin and other nitric acids and esters

  • T65.5X for Toxic effect of nitroglycerin and other nitric acids and esters

  • T65.6 for Toxic effect of paints and dyes, not elsewhere classified

  • T65.6X for Toxic effect of paints and dyes, not elsewhere classified

  • T65.8 for Toxic effect of other specified substances

  • T65.81 for Toxic effect of latex

  • T65.82 for Toxic effect of harmful algae and algae toxins

  • T65.83 for Toxic effect of fiberglass

  • T65.84 for Toxic effect of xylazine

  • T65.85 for Toxic effect of medetomidine

  • T65.89 for Toxic effect of other specified substances

  • T65.9 for Toxic effect of unspecified substance

  • T65.91 for Toxic effect of unspecified substance, accidental (unintentional)

  • T65.92 for Toxic effect of unspecified substance, intentional self-harm

  • T65.93 for Toxic effect of unspecified substance, assault

  • T65.94 for Toxic effect of unspecified substance, undetermined

Coding GuidelinesGuidance

The appropriate 7th character is to be added to each code from block Toxic effect of other and unspecified substances (T65). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T65: its own notes plus those printed at block T51-T65 and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block T51-T65 Toxic effects of substances chiefly nonmedicinal as to source applies to 1,680 codes
  • contact with and (suspected) exposure to toxic substances (Z77.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T51-T65 Toxic effects of substances chiefly nonmedicinal as to source applies to 1,680 codes
  • code(s):
  • for all associated manifestations of toxic effect, such as: respiratory conditions due to external agents (J60-J70)
  • personal history of foreign body fully removed (Z87.821)
  • to identify any retained foreign body, if applicable (Z18.-)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Block T51-T65 Toxic effects of substances chiefly nonmedicinal as to source applies to 1,680 codes
  • When no intent is indicated code to accidental. Undetermined intent is only for use when there is specific documentation in the record that the intent of the toxic effect cannot be determined.
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

  • The appropriate 7th character is to be added to each code from category T65
Values for category T65 Encounter: Initial, Subsequent, Sequela
  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Patient EducationClinical

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T65Overview

What is the ICD-10 code for toxic effect of other and unspecified substances?

T65 is the ICD-10-CM category for toxic effect of other and unspecified substances, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is T65 (Toxic effect of other and unspecified substances) a billable code?

No. This is a category header that groups the codes for toxic effect of other and unspecified substances, and headers cannot be submitted on claims. Claims for toxic effect of other and unspecified substances need a more specific code from this category, such as T65.0X1A, T65.0X1D, and T65.0X1S.

Can T65 be reported with a code from Z77?

Not as a rule. The Excludes1 note at block T51-T65, which applies to T65, lists "contact with and (suspected) exposure to toxic substances (Z77.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).