2026 ICD-10-CM Diagnosis Code E80.6Other disorders of bilirubin metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E80

ICD-10-CM E80.6
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E80.6 is a billable ICD-10-CM diagnosis code for other disorders of bilirubin metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 441 through 443. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E80.6
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of bilirubin metabolism
Short Description
Other disorders of bilirubin metabolism
Same as the full description in the CMS dataset.
Parent Code
E80
Disorders of porphyrin and bilirubin metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE80Disorders of porphyrin and bilirubin metabolism
This CodeE80.6Other disorders of bilirubin metabolism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired hyperbilirubinemia
  • Conjugated hyperbilirubinemia
  • Cyclic premenstrual unconjugated hyperbilirubinemia
  • Delayed conjugation of bilirubin
  • Disorders of bilirubin excretion
  • Dubin-Johnson syndrome
  • Hyperbilirubinemia
  • Hyperbilirubinemia - conjugated - type III
  • Inherited disorder of bilirubin metabolism
  • Neonatal jaundice due to Dubin-Johnson syndrome
  • Neonatal jaundice due to Rotor's syndrome
  • Physiological hyperbilirubinemia
  • Rotor syndrome
  • Unconjugated hyperbilirubinemia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Dubin-Johnson syndrome
  • Rotor's syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Bilirubin metabolism disorder
      • specified NEC
    • Defect, defective
      • bilirubin excretion NEC
    • Disorder(of)
      • bilirubin excretion
    • Disorder(of)
      • metabolism NOS
        • bilirubin
          • specified NEC
    • Dubin-Johnson disease or syndrome
    • Hyperbilirubinemia
      • constitutional
    • Hyperbilirubinemia
      • familial conjugated
    • Rotor's disease or syndrome

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Crigler-Najjar Syndrome

    a familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. it is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.

  • Gilbert Disease

    a benign familial disorder, transmitted as an autosomal dominant trait. it is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.

  • Hyperbilirubinemia

    a condition characterized by an abnormal increase of bilirubin in the blood, which may result in jaundice. bilirubin, a breakdown product of heme, is normally excreted in the bile or further catabolized before excretion in the urine.

  • Hyperbilirubinemia, Hereditary

    inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.

  • Hyperbilirubinemia, Neonatal

    accumulation of bilirubin, a breakdown product of heme proteins, in the blood during the first weeks of life. this may lead to neonatal jaundice. the excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. the condition may be self-limiting (physiological neonatal jaundice) or pathological with toxic levels of bilirubin.

  • Jaundice, Chronic Idiopathic

    a benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. there is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. the liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E80.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
277.4 Dis bilirubin excretion
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E80.6Overview

Is E80.6 (Disorders of porphyrin and bilirubin metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of bilirubin metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E80.6 group to?

When other disorders of bilirubin metabolism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 441, 442, 443, with relative weights from 0.6997 to 1.7947 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E80.6?

Under the General Equivalence Mappings, other disorders of bilirubin metabolism converts to ICD-9-CM 277.4 (dis bilirubin excretion). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.