2027 ICD-10-CM Diagnosis Code E80.6Other disorders of bilirubin metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E80

ICD-10-CM E80.6
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E80.6 is a billable ICD-10-CM diagnosis code for other disorders of bilirubin metabolism. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 441 through 443. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E80.6
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of bilirubin metabolism
Short Description
Other disorders of bilirubin metabolism
Same as the full description in the CMS dataset.
Parent Code
Disorders of porphyrin and bilirubin metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE80Disorders of porphyrin and bilirubin metabolism
This CodeE80.6Other disorders of bilirubin metabolism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired hyperbilirubinemia
  • Conjugated hyperbilirubinemia
  • Cyclic premenstrual unconjugated hyperbilirubinemia
  • Delayed conjugation of bilirubin
  • Disorders of bilirubin excretion
  • Dubin-Johnson syndrome
  • Hyperbilirubinemia
  • Hyperbilirubinemia - conjugated - type III
  • Inherited disorder of bilirubin metabolism
  • Neonatal jaundice due to Dubin-Johnson syndrome
  • Neonatal jaundice due to Rotor's syndrome
  • Physiological hyperbilirubinemia
  • Rotor syndrome
  • Unconjugated hyperbilirubinemia

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E80.6: its own notes plus those printed at E80, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From E80 Disorders of porphyrin and bilirubin metabolism applies to 10 codes
  • defects of catalase and peroxidase

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Dubin-Johnson syndrome
  • Rotor's syndrome

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E80.6, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming E80.6: they are not reported together with it, unless the two conditions are unrelated.

  • Block P50-P61 Hemorrhagic and hematological disorders of newborn
    Dubin-Johnson syndrome (E80.6)

Index to Diseases and InjuriesGuidance

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E80.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
277.4 Dis bilirubin excretion
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E80.6Overview

What is the ICD-10 code for other disorders of bilirubin metabolism?

The ICD-10-CM code for other disorders of bilirubin metabolism is E80.6 (sometimes written as E806). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E80.6 (Disorders of porphyrin and bilirubin metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of bilirubin metabolism on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E80.6 group to?

When other disorders of bilirubin metabolism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 442, 441, 443, with relative weights from 0.6890 to 1.8226 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E80.6 be reported with a code from E34.5?

Not as a rule. The Excludes1 note at block E70-E88, which applies to E80.6, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of E80.6?

Under the General Equivalence Mappings, other disorders of bilirubin metabolism converts to ICD-9-CM 277.4 (dis bilirubin excretion). The mapping is approximate, so confirm the match fits the documentation.