2027 ICD-10-CM Diagnosis Code E77.8Other disorders of glycoprotein metabolism
ICD-10-CM Codes›E00–E89›E70-E88›E77
- Billable — Valid for Submission
- Chronic Condition
E77.8 is a billable ICD-10-CM diagnosis code for other disorders of glycoprotein metabolism. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
E77.8 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E77.8 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alpha-2-antitrypsin deficiency
- Alpha-N-acetylgalactosaminidase deficiency
- Alpha-N-acetylgalactosaminidase deficiency type 1
- Alpha-N-acetylgalactosaminidase deficiency type 2
- Alpha-N-acetylgalactosaminidase deficiency type 3
- CAD-CDG - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase congenital disorder of glycosylation
- Carbohydrate deficient glycoprotein syndrome type 1m
- Carbohydrate deficient glycoprotein syndrome type 1o
- Carbohydrate deficient glycoprotein syndrome type 2a
- Carbohydrate deficient glycoprotein syndrome type 2d
- Carbohydrate deficient glycoprotein syndrome type 2k
- Carbohydrate deficient glycoprotein syndrome type II due to MAN1B1 deficiency
- Carbohydrate-deficient glycoprotein syndrome
- Carbohydrate-deficient glycoprotein syndrome type I
- Carbohydrate-deficient glycoprotein syndrome type II
- Carbohydrate-deficient glycoprotein syndrome type III
- COG2-related congenital disorder of glycosylation
- COG6-CGD - component of oligomeric golgi complex 6-congenital disorder of glycosylation
- Congenital disorder of glycosylation type Ia
- Disorder of sialic acid metabolism
- Edema due to hypoproteinemia
- Glycoprotein storage disorder
- Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency
- Mannosephosphate isomerase congenital disorder of glycosylation
- NGLY1-congenital disorder of deglycosylation
- Normocytic anemia
- Pulmonary edema due to hypoproteinemia
- TMEM199 congenital disorder of glycosylation
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E77.8: its own notes plus those printed at block E70-E88 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
Hypoproteinemia E77.8
Syndrome See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hypoproteinemia
a condition in which total serum protein level is below the normal range. hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, edema, or proteinuria.
Patient EducationClinical
Carbohydrate Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.
Read the full article at MedlinePlus
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Convert E77.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E77.8Overview
What is the ICD-10 code for other disorders of glycoprotein metabolism?
The ICD-10-CM code for other disorders of glycoprotein metabolism is E77.8 (sometimes written as E778). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E77.8 (Disorders of glycoprotein metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of glycoprotein metabolism on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E77.8 group to?
When other disorders of glycoprotein metabolism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E77.8 be reported with a code from E34.5?
Not as a rule. The Excludes1 note at block E70-E88, which applies to E77.8, lists "androgen insensitivity syndrome (E34.5-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E77.8?
Under the General Equivalence Mappings, other disorders of glycoprotein metabolism converts to ICD-9-CM 272.7 (lipidoses). The mapping is approximate, so confirm the match fits the documentation.
Does E77.8 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E77.8 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
