2027 ICD-10-CM Diagnosis Code E53.8Deficiency of other specified B group vitamins

ICD-10-CM Codes›E00–E89›E50-E64›E53

ICD-10-CM E53.8
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E53.8 is a billable ICD-10-CM diagnosis code for deficiency of other specified B group vitamins. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.

Code Identity

ICD-10-CM Code
E53.8
Billable Status
Yes — Valid for Submission
Code Describes
Deficiency of other specified B group vitamins
Short Description
Deficiency of other specified B group vitamins
Same as the full description in the CMS dataset.
Parent Code
E53
Deficiency of other B group vitamins

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE50-E64Other nutritional deficiencies
CategoryE53Deficiency of other B group vitamins
This CodeE53.8Deficiency of other specified B group vitamins

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Biotin deficiency
  • Biotin deficiency disease
  • Cerebral degeneration due to vitamin B12 deficiency
  • Choline deficiency
  • Cobalamin deficiency
  • Cranial neuropathy due to micronutrient deficiency
  • Dementia due to cobalamin deficiency
  • Dementia due to deficiency of folic acid
  • Dementia due to nutritional deficiency
  • Dermatosis associated with biotin deficiency
  • Disorder of vitamin B12
  • Encephalopathy due to folate deficiency
  • Encephalopathy due to vitamin B12 deficiency
  • Encephalopathy due to vitamin deficiency
  • Folate deficiency glossitis
  • Folic acid deficiency
  • Inadequate intake of biotin
  • Inadequate intake of folate and/or folate derivative
  • Inadequate intake of pantothenic acid
  • Inadequate intake of vitamin B12 and/or vitamin B12 derivative
  • Myelopathy due to folate deficiency
  • Myelopathy due to nutritional deficiency
  • Myelopathy due to vitamin B12 deficiency
  • Neuropathy due to folic acid deficiency
  • Neuropathy due to vitamin B deficiency
  • Neuropathy due to vitamin B12 deficiency
  • Neuropathy due to vitamin B6 deficiency
  • Nutritional optic neuropathy
  • Optic neuropathy due to folate deficiency
  • Optic neuropathy due to micronutrient deficiency
  • Pantothenic acid deficiency
  • Polyneuropathy due to vitamin B deficiency
  • Subacute combined degeneration of spinal cord
  • Vitamin B12 deficiency
  • White matter disorder due to vitamin B12 deficiency

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E53.8: its own notes plus those printed at E53, block E50-E64, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Biotin deficiency
  • Cyanocobalamin deficiency
  • Folate deficiency
  • Folic acid deficiency
  • Pantothenic acid deficiency
  • Vitamin B12 deficiency

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E53.8 itself
  • folate deficiency anemia (D52.-)
From E53 Deficiency of other B group vitamins applies to 4 codes
  • sequelae of vitamin B deficiency (E64.8)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

On E53.8 itself
  • vitamin B12 deficiency anemia (D51.-)
From Block E50-E64 Other nutritional deficiencies applies to 50 codes

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E53.8, its category, or a range that includes it.

Applicable To 1

These notes mention E53.8.

  • P00.4 Newborn affected by maternal nutritional disorders
    Newborn affected by maternal disorders classifiable to E40-E64 names E40-E64, which includes this code

Excludes1 4

These codes carry an Excludes1 note naming E53.8: they are not reported together with it, unless the two conditions are unrelated.

  • D52 Folate deficiency anemia
    folate deficiency without anemia (E53.8)
  • D81.81 Biotin-dependent carboxylase deficiency
    biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)
  • T45.2X6 Underdosing of vitamins
    vitamin deficiencies (E50-E56) names E50-E56, which includes this code
  • Z72.4 Inappropriate diet and eating habits
    malnutrition and other nutritional deficiencies (E40-E64) names E40-E64, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming E53.8: its condition is not part of those codes, and both may be reported when the patient has both.

  • D51 Vitamin B12 deficiency anemia
    deficiency of other B group vitamins (E53-) names E53-, which includes this code

Code First 5

These codes say to code first a condition named in the note, and E53.8 is one of the conditions named.

  • F02 Dementia in other diseases classified elsewhere
    vitamin B deficiency (E53.8)
  • G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
    vitamin B12 deficiency (E53.8)
  • F06.7 Mild neurocognitive disorder due to known physiological condition
    vitamin B deficiency (E53.-) names E53.-, which includes this code
  • G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
    cerebral degeneration (due to) vitamin B deficiency, except thiamine (E52-E53.-) names E52-E53, which includes this code
  • G63 Polyneuropathy in diseases classified elsewhere
    nutritional deficiency (E40-E64) names E40-E64, which includes this code

Notes 1

These notes mention E53.8.

  • E64 Sequelae of malnutrition and other nutritional deficiencies
    This category is to be used to indicate conditions in categories E43, E44, E46, E50-E63 as the cause of sequelae, which are themselves classified elsewhere. The 'sequelae' include conditions specified as such; they also include the late effects of diseases classifiable to the above categories if the disease itself is no longer present names E50-E63, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END007
Nutritional deficiencies
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

B Vitamins

The B vitamins are:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E53.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
266.2 B-complex defic NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E53.8Overview

What is the ICD-10 code for deficiency of other specified B group vitamins?

The ICD-10-CM code for deficiency of other specified B group vitamins is E53.8 (sometimes written as E538). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E53.8 (Deficiency of other B group vitamins) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report deficiency of other specified B group vitamins on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E53.8 group to?

When deficiency of other specified B group vitamins is the principal diagnosis on an inpatient stay, it groups to MS-DRG 641, 640, with relative weights from 0.7864 to 1.3392 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E53.8 be reported with a code from D52?

Not as a rule. The Excludes1 note on E53.8 lists "folate deficiency anemia (D52.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of E53.8?

Under the General Equivalence Mappings, deficiency of other specified B group vitamins converts to ICD-9-CM 266.2 (b-complex defic NEC). The mapping is approximate, so confirm the match fits the documentation.