2026 ICD-10-CM Diagnosis Code E53.8Deficiency of other specified B group vitamins

ICD-10-CM Codes›E00–E89›E50-E64›E53

ICD-10-CM E53.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E53.8 is a billable ICD-10-CM diagnosis code for deficiency of other specified B group vitamins. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.

Code Identity

ICD-10-CM Code
E53.8
Billable Status
Yes — Valid for Submission
Code Describes
Deficiency of other specified B group vitamins
Short Description
Deficiency of other specified B group vitamins
Same as the full description in the CMS dataset.
Parent Code
E53
Deficiency of other B group vitamins

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE50-E64Other nutritional deficiencies
CategoryE53Deficiency of other B group vitamins
This CodeE53.8Deficiency of other specified B group vitamins

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Biotin deficiency
  • Biotin deficiency disease
  • Cerebral degeneration due to vitamin B12 deficiency
  • Choline deficiency
  • Cobalamin deficiency
  • Cranial neuropathy due to micronutrient deficiency
  • Dementia due to cobalamin deficiency
  • Dementia due to deficiency of folic acid
  • Dementia due to nutritional deficiency
  • Dermatosis associated with biotin deficiency
  • Disorder of vitamin B12
  • Encephalopathy due to folate deficiency
  • Encephalopathy due to vitamin B12 deficiency
  • Encephalopathy due to vitamin deficiency
  • Folate deficiency glossitis
  • Folic acid deficiency
  • Inadequate intake of biotin
  • Inadequate intake of folate and/or folate derivative
  • Inadequate intake of pantothenic acid
  • Inadequate intake of vitamin B12 and/or vitamin B12 derivative
  • Myelopathy due to folate deficiency
  • Myelopathy due to nutritional deficiency
  • Myelopathy due to vitamin B12 deficiency
  • Neuropathy due to folic acid deficiency
  • Neuropathy due to vitamin B deficiency
  • Neuropathy due to vitamin B12 deficiency
  • Neuropathy due to vitamin B6 deficiency
  • Nutritional optic neuropathy
  • Optic neuropathy due to folate deficiency
  • Optic neuropathy due to micronutrient deficiency
  • Pantothenic acid deficiency
  • Polyneuropathy due to vitamin B deficiency
  • Subacute combined degeneration of spinal cord
  • Vitamin B12 deficiency
  • White matter disorder due to vitamin B12 deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Biotin deficiency
  • Cyanocobalamin deficiency
  • Folate deficiency
  • Folic acid deficiency
  • Pantothenic acid deficiency
  • Vitamin B12 deficiency

Type 1 Excludes

  • folate deficiency anemia D52
  • vitamin B12 deficiency anemia D51

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Acid
      • deficiency
        • folic
    • Acid
      • deficiency
        • pantothenic
    • Avitaminosis(multiple)
      • B12
    • Chacaleh
    • Deficiency, deficient
      • biotin
    • Deficiency, deficient
      • choline
    • Deficiency, deficient
      • cyanocobalamin
    • Deficiency, deficient
      • folate
    • Deficiency, deficient
      • folic acid
    • Deficiency, deficient
      • inositol (B complex)
    • Deficiency, deficient
      • pantothenic acid
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • B12
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • folic acid
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • group B
          • specified NEC
    • Deficiency, deficient
      • vitamin (multiple) NOS
        • H (biotin)
    • Degeneration, degenerative
      • brain (cortical) (progressive)
        • in
          • vitamin B12 deficiency
    • Degeneration, degenerative
      • combined (spinal cord) (subacute)
    • Degeneration, degenerative
      • combined (spinal cord) (subacute)
        • in (due to)
          • vitamin B12 deficiency
    • Dementia(degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety)
      • in (due to)
        • vitamin B12 deficiency
    • Dementia(degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety)
      • in (due to)
        • vitamin B12 deficiency
          • with behavioral disturbance
    • Electric feet syndrome
    • Lightning(effects) (stroke) (struck by)
      • foot
    • Melalgia, nutritional
    • Myelopathy(spinal cord)
      • vitamin B12
    • Neuropathy, neuropathic
      • vitamin B12
    • Painful
      • feet syndrome
    • Polyneuropathy(peripheral)
      • in (due to)
        • vitamin B12 deficiency
    • Syndrome
      • electric feet
    • Syndrome
      • Gopalan's (burning feet)
    • Syndrome
      • painful
        • feet

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END007
Nutritional deficiencies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Folic Acid Deficiency

    a nutritional condition produced by a deficiency of folic acid in the diet. many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. alcohol interferes with its intermediate metabolism and absorption. folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. this deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. it is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed)

  • Choline Deficiency

    a condition produced by a deficiency of choline in animals. choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. combined deficiency of choline (included in the b vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (from saunders dictionary & encyclopedia of laboratory medicine and technology, 1984)

  • Folic Acid

    a member of the vitamin b family that stimulates the hematopoietic system. it is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

  • Choline

    a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Patient EducationClinical

B Vitamins

The B vitamins are:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E53.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
266.2 B-complex defic NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E53.8Overview

Is E53.8 (Deficiency of other B group vitamins) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report deficiency of other specified B group vitamins on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E53.8 group to?

When deficiency of other specified B group vitamins is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E53.8?

Under the General Equivalence Mappings, deficiency of other specified B group vitamins converts to ICD-9-CM 266.2 (b-complex defic NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.