Deficiency of other B group vitamins (E53) ICD-10-CM
The E53 code range covers deficiency of other b group vitamins with 5 ICD-10-CM diagnosis codes. 4 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- sequelae of vitamin B deficiency E64.8
Codes in the E53 Range 5 codes · 4 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E53 range.
Choline
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Choline Deficiency
A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Folic Acid
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
Folic Acid Deficiency
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Riboflavin Deficiency
A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)
Vitamin B Deficiency
A condition due to deficiency in any member of the VITAMIN B COMPLEX. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat.
About the E53 Code Range
The ICD-10 code section E53 covers deficiencies of certain B group vitamins beyond the commonly coded types. These codes are used to specifically identify medical conditions caused by lack of vitamins like riboflavin (B2), pyridoxine (B6), and other specified or unspecified B vitamins.
For example, E53.0 is used when diagnosing riboflavin deficiency, also known as ariboflavinosis or anemia due to riboflavin lack. Similarly, E53.1 codes for pyridoxine (vitamin B6) deficiency, which can cause non-megaloblastic anemia and related symptoms. The E53.8 code applies to a range of other B vitamin deficiencies, including vitamin B12 and folate deficiencies, which are linked to neurological issues such as dementia, neuropathy, and myelopathy. Lastly, E53.9 is used when the vitamin B deficiency is noted but not specified, encompassing broader terms like vitamin B-complex deficiency or burning feet syndrome. These codes help healthcare professionals accurately document and treat various nutritional deficiencies related to B vitamins.
Questions About This Page
How many billable codes are in the E53 range?
Of the 5 codes in this range, 4 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E53 range classify?
The range classifies deficiency of other b group vitamins. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
