2026 ICD-10-CM Diagnosis Code E53.1Pyridoxine deficiency
ICD-10-CM Codes›E00–E89›E50-E64›E53
- Billable — Valid for Submission
- Not Chronic
E53.1 is a billable ICD-10-CM diagnosis code for pyridoxine deficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. Coders also document this condition as anemia due to vitamin B>6< deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional deficiencies.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anemia due to vitamin B>6< deficiency
- Inadequate intake of vitamin B6 and/or vitamin B6 derivative
- Non megaloblastic anemia associated with nutritional deficiency
- Vitamin B6 deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Vitamin B6 deficiency
Type 1 Excludes
- pyridoxine-responsive sideroblastic anemia D64.3
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Avitaminosis (multiple) - See Also: Deficiency, vitamin; - E56.9
- B6 - E53.1
- pyracin (alpha) (beta) - E53.1
- pyridoxal - E53.1
- pyridoxamine - E53.1
- pyridoxine (derivatives) - E53.1
- vitamin (multiple) NOS - E56.9
- B6 - E53.1
- Dependence (on) (syndrome) - F19.20
- vitamin B6 - E53.1
- Polyneuropathy (peripheral) - G62.9
- vitamin B6 - E53.1
- Syndrome - See Also: Disease;
- vitamin B6 deficiency - E53.1
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Avitaminosis(multiple)
- B6
- Deficiency, deficient
- pyracin (alpha) (beta)
- Deficiency, deficient
- pyridoxal
- Deficiency, deficient
- pyridoxamine
- Deficiency, deficient
- pyridoxine (derivatives)
- Deficiency, deficient
- vitamin (multiple) NOS
- B6
- Dependence(on) (syndrome)
- vitamin B6
- Polyneuropathy(peripheral)
- in (due to)
- deficiency (of)
- vitamin B6
- Syndrome
- vitamin B6 deficiency
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
B Vitamins
The B vitamins are:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E53.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E53.1Overview
Is E53.1 (Deficiency of other B group vitamins) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report pyridoxine deficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E53.1 group to?
When pyridoxine deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E53.1?
Under the General Equivalence Mappings, pyridoxine deficiency converts to ICD-9-CM 266.1 (vitamin b6 deficiency). The mapping is a direct match.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
