2026 ICD-10-CM Diagnosis Code D76.2Hemophagocytic syndrome, infection-associated

ICD-10-CM Codes›D50–D89›D70-D77›D76

ICD-10-CM D76.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D76.2 is a billable ICD-10-CM diagnosis code for hemophagocytic syndrome, infection-associated. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 39 closely related codes. Coders also document this condition as hemophagocytic lymphohistiocytosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

D76.2 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, and ESRD (V24) category 47 for payment year 2026.

Code Identity

ICD-10-CM Code
D76.2
Billable Status
Yes — Valid for Submission
Code Describes
Hemophagocytic syndrome, infection-associated
Short Description
Hemophagocytic syndrome, infection-associated
Same as the full description in the CMS dataset.
Parent Code
D76
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD76Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
This CodeD76.2Hemophagocytic syndrome, infection-associated

Medicare Risk Adjustment (HCC)Billing

D76.2 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 47
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 47 · ESRD (V21): HCC 47 · ESRD (V24): HCC 47
ESRD V21 weights: 0.097 dialysis, 0.549–0.688 functioning graft · ESRD V24 weights: 0.078 dialysis, 0.523–0.803 functioning graft
Part D (RxHCC)
Not mapped
D76.2 does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hemophagocytic lymphohistiocytosis
  • Hemophagocytic lymphohistiocytosis due to infection
  • Hemophagocytic syndrome with human immunodeficiency virus infection
  • Infection-associated macrophage activation syndrome
  • Macrophage activation syndrome
  • Secondary hemophagocytic lymphohistiocytosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code to identify infectious agent or disease.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Macrophage Activation Syndrome

    a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of t-lymphocytes and macrophages. it is seen predominantly in children with systemic onset juvenile idiopathic arthritis.

  • Grade 1 Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    asymptomatic or mild symptoms; requiring clinical and/or diagnostic evaluation; intervention not indicated

  • Grade 2 Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    moderate symptoms; intervention indicated (e.g., immunosuppressive agents)

  • Grade 3 Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    severe or medically significant but not immediately life threatening; hospitalization or prolongation of existing hospitalization indicated

  • Grade 4 Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    life-threatening consequences; urgent intervention indicated

  • Grade 5 Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    death

  • Secondary Hemophagocytic Lymphohistiocytosis, CTCAE

    a disorder characterized by the development of a pathological and biochemical hyperinflammatory syndrome characterized by fever, cytopenias, hyperferritinemia, coagulopathy, hypofibrinogenemia and/or transaminitis and is attributable to therapy.

  • Secondary Hemophagocytic Lymphohistiocytosis

    hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.

  • Refractory Secondary Hemophagocytic Lymphohistiocytosis

    secondary hemophagocytic lymphohistiocytosis that is resistant to treatment.

Convert D76.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.4 Hemophagocytic syndromes
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D76.2Overview

What is the ICD-10 code for hemophagocytic syndrome, infection-associated?

The ICD-10-CM code for hemophagocytic syndrome, infection-associated is D76.2 (sometimes written as D762). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Is D76.2 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hemophagocytic syndrome, infection-associated on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D76.2 group to?

When hemophagocytic syndrome, infection-associated is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Is D76.2 a CC or MCC?

CMS lists D76.2 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 39 closely related codes in its exclusion list.

What is the ICD-9 equivalent of D76.2?

Under the General Equivalence Mappings, hemophagocytic syndrome, infection-associated converts to ICD-9-CM 288.4 (hemophagocytic syndromes). The mapping is approximate, so confirm the match fits the documentation.

Does D76.2 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. D76.2 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), and ESRD (V24) category 47 (Disorders of Immunity).