2027 ICD-10-CM Diagnosis Code D76.2Hemophagocytic syndrome, infection-associated

ICD-10-CM Codes›D50–D89›D70-D77›D76

ICD-10-CM D76.2
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D76.2 is a billable ICD-10-CM diagnosis code for hemophagocytic syndrome, infection-associated. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 814 through 816. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 39 closely related codes. Coders also document this condition as hemophagocytic lymphohistiocytosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

D76.2 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 47 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 47, ESRD (V21) category 47, and ESRD (V24) category 47 for payment year 2027.

Code Identity

ICD-10-CM Code
D76.2
Billable Status
Yes — Valid for Submission
Code Describes
Hemophagocytic syndrome, infection-associated
Short Description
Hemophagocytic syndrome, infection-associated
Same as the full description in the CMS dataset.
Parent Code
D76
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD76Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
This CodeD76.2Hemophagocytic syndrome, infection-associated

Medicare Risk Adjustment (HCC)Billing

D76.2 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 47
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 47 · ESRD (V21): HCC 47 · ESRD (V24): HCC 47
ESRD V21 weights: 0.097 dialysis, 0.549–0.688 functioning graft · ESRD V24 weights: 0.078 dialysis, 0.523–0.803 functioning graft
Part D (RxHCC)
Not mapped
D76.2 does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hemophagocytic lymphohistiocytosis
  • Hemophagocytic lymphohistiocytosis due to infection
  • Hemophagocytic syndrome with human immunodeficiency virus infection
  • Infection-associated macrophage activation syndrome
  • Macrophage activation syndrome
  • Secondary hemophagocytic lymphohistiocytosis

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D76.2: its own notes plus those printed at D76 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue applies to 3 codes
  • (Abt-) Letterer-Siwe disease (C96.0)
  • eosinophilic granuloma (C96.6)
  • Hand-Schüller-Christian disease (C96.5)
  • histiocytic medullary reticulosis (C96.9)
  • histiocytic sarcoma (C96.A)
  • histiocytosis X, multifocal (C96.5)
  • histiocytosis X, unifocal (C96.6)
  • Langerhans-cell histiocytosis, multifocal (C96.5)
  • Langerhans-cell histiocytosis NOS (C96.6)
  • Langerhans-cell histiocytosis, unifocal (C96.6)
  • leukemic reticuloendotheliosis (C91.4-)
  • lipomelanotic reticulosis (I89.8)
  • malignant histiocytosis (C96.A)
  • malignant reticulosis (C86.0)
  • nonlipid reticuloendotheliosis (C96.0)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code to identify infectious agent or disease.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Reactive Hemophagocytic Syndrome

    proliferation of histiocytes in response to viral, bacterial, fungal, or parasitic infections.

Convert D76.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.4 Hemophagocytic syndromes
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D76.2Overview

What is the ICD-10 code for hemophagocytic syndrome, infection-associated?

The ICD-10-CM code for hemophagocytic syndrome, infection-associated is D76.2 (sometimes written as D762). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D76.2 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hemophagocytic syndrome, infection-associated on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D76.2 group to?

When hemophagocytic syndrome, infection-associated is the principal diagnosis on an inpatient stay, it groups to MS-DRG 816, 814, 815, with relative weights from 0.7378 to 2.0727 depending on complications. Higher weights mean higher Medicare reimbursement.

Is D76.2 a CC or MCC?

CMS lists D76.2 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 39 closely related codes in its exclusion list.

Can D76.2 be reported with C96.0?

Not as a rule. The Excludes1 note at D76, which applies to D76.2, lists "(Abt-) Letterer-Siwe disease (C96.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does D76.2 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. D76.2 mapped to HCC 47 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 47 (Disorders of Immunity), ESRD (V21) category 47 (Disorders of Immunity), and ESRD (V24) category 47 (Disorders of Immunity).