2027 ICD-10-CM Diagnosis Code D60.1Transient acquired pure red cell aplasia

ICD-10-CM Codes›D50–D89›D60-D64›D60

ICD-10-CM D60.1
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D60.1 is a billable ICD-10-CM diagnosis code for transient acquired pure red cell aplasia. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 110 closely related codes. Coders also document this condition as acquired red cell aplasia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia.

D60.1 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 46 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 46, ESRD (V21) category 46, ESRD (V24) category 46, and RxHCC Part D (V08) category 96 for payment year 2027.

Code Identity

ICD-10-CM Code
D60.1
Billable Status
Yes — Valid for Submission
Code Describes
Transient acquired pure red cell aplasia
Short Description
Transient acquired pure red cell aplasia
Same as the full description in the CMS dataset.
Parent Code
D60
Acquired pure red cell aplasia [erythroblastopenia]

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD60-D64Aplastic and other anemias and other bone marrow failure syndromes
CategoryD60Acquired pure red cell aplasia [erythroblastopenia]
This CodeD60.1Transient acquired pure red cell aplasia

Medicare Risk Adjustment (HCC)Billing

D60.1 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 46
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 46 · ESRD (V21): HCC 46 · ESRD (V24): HCC 46
ESRD V21 weights: 0.180 dialysis, 0.766–1.325 functioning graft · ESRD V24 weights: 0.223 dialysis, 0.748–4.064 functioning graft
Part D (RxHCC)
RxHCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired red cell aplasia
  • Acute pure red cell aplasia
  • Pure red cell aplasia
  • Transient acquired pure red cell aplasia
  • Transient erythroblastopenia of childhood

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D60.1: its own notes plus those printed at D60 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From D60 Acquired pure red cell aplasia [erythroblastopenia] applies to 4 codes
  • red cell aplasia (acquired) (adult) (with thymoma)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From D60 Acquired pure red cell aplasia [erythroblastopenia] applies to 4 codes
  • congenital red cell aplasia (D61.01)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 3 (D50-D89) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism applies to 324 codes
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD003
Aplastic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D60.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
284.81 Red cell aplasia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D60.1Overview

What is the ICD-10 code for transient acquired pure red cell aplasia?

The ICD-10-CM code for transient acquired pure red cell aplasia is D60.1 (sometimes written as D601). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D60.1 (Acquired pure red cell aplasia [erythroblastopenia]) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report transient acquired pure red cell aplasia on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D60.1 group to?

When transient acquired pure red cell aplasia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.

Is D60.1 a CC or MCC?

CMS lists D60.1 as an MCC (major complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 110 closely related codes in its exclusion list.

Can D60.1 be reported with D61.01?

Not as a rule. The Excludes1 note at D60, which applies to D60.1, lists "congenital red cell aplasia (D61.01)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does D60.1 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. D60.1 mapped to HCC 46 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 46 (Severe Hematological Disorders), ESRD (V21) category 46 (Severe Hematological Disorders), ESRD (V24) category 46 (Severe Hematological Disorders), and RxHCC Part D (V08) category 96 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias).