2026 ICD-10-CM Diagnosis Code D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

ICD-10-CM Codes›D50–D89›D55-D59›D59

ICD-10-CM D59.5
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D59.5 is a billable ICD-10-CM diagnosis code for paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as occlusion of microvasculature of skin caused by platelet plug. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D59.5
Billable Status
Yes — Valid for Submission
Code Describes
Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
Short Description
Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
Same as the full description in the CMS dataset.
Parent Code
D59
Acquired hemolytic anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD59Acquired hemolytic anemia
This CodeD59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Occlusion of microvasculature of skin caused by platelet plug
  • Occlusion of microvasculature of skin due to platelet thrombus associated with paroxysmal nocturnal hemoglobinuria
  • Paroxysmal nocturnal hemoglobinuria
  • Thrombophilia due to paroxysmal nocturnal hemoglobinuria

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • hemoglobinuria NOS R82.3

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hematuria
      • paroxysmal
        • nocturnal
    • Hemoglobinemia
      • paroxysmal
        • nocturnal
    • Hemoglobinuria
      • nocturnal (paroxysmal)
    • Hemoglobinuria
      • paroxysmal (cold)
        • nocturnal
    • Marchiafava-Micheli syndrome

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Acquired Hemolytic Anemia

    hemolytic anemia, the cause of which is not present at birth.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D59.5 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
283.2 Hemolytic hemoglobinuria
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D59.5Overview

Is D59.5 (Acquired hemolytic anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D59.5 group to?

When paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D59.5?

Under the General Equivalence Mappings, paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] converts to ICD-9-CM 283.2 (hemolytic hemoglobinuria). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.