2026 ICD-10-CM Diagnosis Code D49.59Neoplasm of unspecified behavior of other genitourinary organ

AHRQ’s CCSR groups this code into broader clinical categories.

• Broad Ligament

  a broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.

• Internal Hernia

  a protrusion of an internal abdominal organ through a hole in an anatomical structure such as a muscle or a membrane. for instance, in paraduodenal hernia the small intestine herniates through an opening in the mesenteries. it includes intra-abdominal and diaphragmatic hernias. in abdominal hernia a protrusion occurs through a weak spot in the muscle of the abdominal wall.

• Clitoris

  an erectile structure homologous with the penis, situated beneath the anterior labial commissure, partially hidden between the anterior ends of the labia minora.

• Pudendal Nerve

  a nerve which originates in the sacral spinal cord (s2 to s4) and innervates the perineum, the external genitalia, the external anal sphincter and the external urethral sphincter. it has three major branches: the perineal nerve, inferior anal nerves, and the dorsal nerve of penis or clitoris.

• Epididymis

  the convoluted cordlike structure attached to the posterior of the testis. epididymis consists of the head (caput), the body (corpus), and the tail (cauda). a network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of spermatozoa.

• Foreskin

  the double-layered skin fold that covers the glans penis, the head of the penis.

• Myometrium

  the smooth muscle coat of the uterus, which forms the main mass of the organ.

• Abruptio Placentae

  premature separation of the normally implanted placenta from the uterus. signs of varying degree of severity include uterine bleeding, uterine muscle hypertonia, and fetal distress or fetal death.

• Annexin A3

  a protein of the annexin family that catalyzes the conversion of 1-d-inositol 1,2-cyclic phosphate and water to 1-d-myo-inositol 1-phosphate.

• Annexin A4

  protein of the annexin family originally isolated from the electric organ of the electric ray torpedo marmorata. it has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized epithelial cells.

• Annexin A5

  a protein of the annexin family isolated from human placenta and other tissues. it inhibits cytosolic phospholipase a2, and displays anticoagulant activity.

• Cadherins

  calcium-dependent cell adhesion proteins. they are important in the formation of adherens junctions between cells. cadherins are classified by their distinct immunological and tissue specificities, either by letters (e- for epithelial, n- for neural, and p- for placental cadherins) or by numbers (cadherin-12 or n-cadherin 2 for brain-cadherin). cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

• Chorionic Villi

  threadlike vascular projections of the chorion. chorionic villi may be free or embedded within the decidua forming the site for exchange of substances between fetal and maternal blood (placenta).

• Cord Blood Stem Cell Transplantation

  transplantation of stem cells collected from the fetal blood remaining in the umbilical cord and the placenta after delivery. included are the hematopoietic stem cells.

• Eutheria

  mammals which nourish their young in utero by means of a complex placenta, and give birth to their young alive. they include primates; carnivora, whales; ruminants; bats; and rodents.

• Folate Receptor 2

  a subtype of gpi-anchored folate receptors that is expressed in placenta and hematopoietic cells.

• Ichthyosis, X-Linked

  chronic form of ichthyosis that is inherited as a sex-linked recessive trait carried on the x-chromosome and transmitted to the male offspring. it is characterized by severe scaling, especially on the extremities, and is associated with steroid sulfatase deficiency.

• Perilipin-3

  a perilipin that localizes to lipid droplets; cytoplasm; endosomes; and plasma membrane, especially in macrophages. it functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. it is also required for the transport of the mannose-6-phosphate receptor from endosomes to the trans-golgi network. its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.

• Placenta

  a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. it includes a fetal portion (chorionic villi) derived from trophoblasts and a maternal portion (decidua) derived from the uterine endometrium. the placenta produces an array of steroid, protein and peptide hormones (placental hormones).

• Placenta Accreta

  abnormal placentation in which all or parts of the placenta are attached directly to the myometrium due to a complete or partial absence of decidua. it is associated with postpartum hemorrhage because of the failure of placental separation.

• Placenta Diseases

  pathological processes or abnormal functions of the placenta.

• Placenta Growth Factor

  an angiogenic protein belonging to the vascular endothelial growth factor family of growth factors originally isolated and cloned from human placental cdna library. there are four isoforms of plgf 1-4 which result from alternative splicing. placenta growth factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.

• Placenta Previa

  abnormal placentation in which the placenta implants in the lower segment of the uterus (the zone of dilation) and may cover part or all of the opening of the cervix. it is often associated with serious antepartum bleeding and premature labor.

• Placenta, Retained

  a placenta that fails to be expelled after birth of the fetus. a placenta is retained when the uterus fails to contract after the delivery of its content, or when the placenta is abnormally attached to the myometrium.

• Placental Circulation

  the circulation of blood, of both the mother and the fetus, through the placenta.

• Placental Extracts

  extracts prepared from placental tissue; they may contain specific but uncharacterized factors or proteins with specific activities.

• Placental Function Tests

  methods used for the assessment of placental function.

• Placental Hormones

  hormones produced by the placenta include chorionic gonadotropin, and placental lactogen as well as steroids (estrogens; progesterone), and neuropeptide hormones similar to those found in the hypothalamus (hypothalamic hormones).

• Placental Insufficiency

  failure of the placenta to deliver an adequate supply of nutrients and oxygen to the fetus.

• Placental Lactogen

  a polypeptide hormone of approximately 25 kda that is produced by the syncytiotrophoblasts of the placenta, also known as chorionic somatomammotropin. it has both growth hormone and prolactin activities on growth, lactation, and luteal steroid production. in women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. placental lactogen is also an insulin antagonist.

• Placentation

  the development of the placenta, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and fetus. the process begins at fertilization, through the development of cytotrophoblasts and syncytiotrophoblasts, the formation of chorionic villi, to the progressive increase in blood vessels to support the growing fetus.

• Plasminogen Inactivators

  important modulators of the activity of plasminogen activators. the inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.

• Pregnancy Proteins

  proteins produced by organs of the mother or the placenta during pregnancy. these proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)

• Pregnancy Trimester, First

  the beginning third of a human pregnancy, from the first day of the last normal menstrual period (menstruation) through the completion of 14 weeks (98 days) of gestation.

• S100 Calcium-Binding Protein A4

  an s100 protein characterized by four helix bundles that form n- and c-terminal ef hand motifs. it functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. aberrant s100a4 activity is associated with neoplasm metastasis; fibrosis; and rheumatoid arthritis.

• Trophoblastic Tumor, Placental Site

  an uncommon variant of choriocarcinoma. it is composed almost entirely of mononuclear cytotrophoblasts (trophoblasts). because its secretion of hcg (chorionic gonadotropin) is low, a large tumor may develop before the hcg can be detected.

• Umbilical Cord Clamping

  method of placing clamps on the umbilical cord before cutting after birth.

• Spermatic Cord

  either of a pair of tubular structures formed by ductus deferens; arteries; veins; lymphatic vessels; and nerves. the spermatic cord extends from the deep inguinal ring through the inguinal canal to the testis in the scrotum.

• Spermatic Cord Torsion

  the twisting of the spermatic cord due to an anatomical abnormality that left the testis mobile and dangling in the scrotum. the initial effect of testicular torsion is obstruction of venous return. depending on the duration and degree of cord rotation, testicular symptoms range from edema to interrupted arterial flow and testicular pain. if blood flow to testis is absent for 4 to 6 h, spermatogenesis may be permanently lost.

• Sterilization Reversal

  procedures to reverse the effect of reproductive sterilization and to regain fertility. reversal procedures include those used to restore the flow in the fallopian tube or the vas deferens.

• Vas Deferens

  the excretory duct of the testes that carries spermatozoa. it rises from the scrotum and joins the seminal vesicles to form the ejaculatory duct.

Anatomical sites in the Table of Neoplasms that reference this code family.

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