2027 ICD-10-CM Diagnosis Code D49.59Neoplasm of unspecified behavior of other genitourinary organ

ICD-10-CM Codes›C00–D49›D49›D49

ICD-10-CM D49.59
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D49.59 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of other genitourinary organ. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 656 through 658, 686 through 688. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code
D49.59
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of other genitourinary organ
Short Description
Neoplasm of unspecified behavior of other GU organ
Parent Code
D49.5
Neoplasm of unspecified behavior of other genitourinary organs

Code Classification

ChapterC00–D49Neoplasms
SectionD49Neoplasms of unspecified behavior
CategoryD49Neoplasms of unspecified behavior
This CodeD49.59Neoplasm of unspecified behavior of other genitourinary organ

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Endometrium, hysterectomy surgical margin, involved by tumor
  • Epithelial neoplasm of ovary
  • Extraprostatic extension of tumor absent
  • Extraprostatic extension of tumor indeterminate
  • Fallopian tube surgical margin, involved by tumor
  • In situ neoplasm of vulva
  • Lesion of clitoris
  • Mixed epithelial neoplasm of ovary
  • Neoplasm of body of penis
  • Neoplasm of body of uterus
  • Neoplasm of body of uterus affecting pregnancy
  • Neoplasm of body of uterus in pregnancy, childbirth and puerperium
  • Neoplasm of broad ligament
  • Neoplasm of cervix uteri affecting pregnancy
  • Neoplasm of clitoris
  • Neoplasm of corpus cavernosum
  • Neoplasm of corpus spongiosum of penis
  • Neoplasm of endocervix
  • Neoplasm of endometrium
  • Neoplasm of epididymis
  • Neoplasm of exocervix
  • Neoplasm of fallopian tube
  • Neoplasm of female genital organ
  • Neoplasm of fundus uteri
  • Neoplasm of glans penis
  • Neoplasm of isthmus of uterus
  • Neoplasm of labia majora
  • Neoplasm of labia minora
  • Neoplasm of male genital organ
  • Neoplasm of myometrium
  • Neoplasm of ovary
  • Neoplasm of parametrium
  • Neoplasm of paraurethral glands
  • Neoplasm of penis
  • Neoplasm of placenta
  • Neoplasm of prepuce
  • Neoplasm of prostate
  • Neoplasm of round ligament of uterus
  • Neoplasm of scrotum
  • Neoplasm of seminal vesicle
  • Neoplasm of skin of penis
  • Neoplasm of spermatic cord
  • Neoplasm of testis
  • Neoplasm of tunica vaginalis
  • Neoplasm of undescended testis
  • Neoplasm of ureter
  • Neoplasm of ureteropelvic junction
  • Neoplasm of urethra
  • Neoplasm of urinary system
  • Neoplasm of urinary tract proper
  • Neoplasm of uterine adnexa
  • Neoplasm of uterine cervix
  • Neoplasm of uterus
  • Neoplasm of uterus affecting pregnancy
  • Neoplasm of vagina
  • Neoplasm of vagina affecting pregnancy
  • Neoplasm of vas deferens
  • Neoplasm of vulva
  • Neoplasm of vulva affecting pregnancy
  • No organ AND/OR tissue, other than fallopian tube, macroscopically involved by tumor
  • Ovarian tumor omental implantation not applicable
  • Paratesticular neoplasm
  • Prostate tumor incidental histologic finding in 5 percent or less of tissue resected
  • Prostate tumor incidental histologic finding in more than 5 percent of tissue resected
  • Sex cord tumor of ovary
  • Tumor microscopically involves only the fallopian tube

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D49.59: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • neoplasms of uncertain behavior (D37-D44, D48)

Notes

General instructions on how these codes are used.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D49.59, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming D49.59: they are not reported together with it, unless the two conditions are unrelated.

  • D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
    neoplasm of unspecified behavior of skin of genital organs (D49.59)
  • Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
    neoplasms of unspecified behavior (D49.-) names D49.-, which includes this code

Notes 1

These notes mention D49.59.

  • D49 Neoplasms of unspecified behavior
    Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth. names D49, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary		Malig.
Secondary		Ca
in situ		BenignUncertainUnspec.
adnexa (uterine)C57.4C79.89D07.39D28.7D39.8D49.59
Bartholin's glandC51.0C79.82D07.1D28.0D39.8D49.59
broad ligamentC57.1C79.82D07.39D28.2D39.8D49.59
bulbourethral glandC68.0C79.19D09.19D30.4D41.3D49.59
cervix (cervical) (uteri) (uterus)C53.9C79.82D06.9D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › canalC53.0C79.82D06.0D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › endocervix (canal) (gland)C53.0C79.82D06.0D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › exocervixC53.1C79.82D06.1D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › external osC53.1C79.82D06.1D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › internal osC53.0C79.82D06.0D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › nabothian glandC53.0C79.82D06.0D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › squamocolumnar junctionC53.8C79.82D06.7D26.0D39.0D49.59
cervix (cervical) (uteri) (uterus) › stumpC53.8C79.82D06.7D26.0D39.0D49.59
clitorisC51.2C79.82D07.1D28.0D39.8D49.59
cord (true) (vocal) › spermaticC63.1C79.82D07.69D29.8D40.8D49.59
corpus › albicansC56.C79.6D07.39D27.D39.1D49.59
corpus › cavernosumC60.2C79.82D07.4D29.0D40.8D49.59
corpus › penisC60.2C79.82D07.4D29.0D40.8D49.59
corpus › uteriC54.9C79.82D07.0D26.1D39.0D49.59
corpus › uteri › isthmusC54.0C79.82D07.0D26.1D39.0D49.59
Cowper's glandC68.0C79.19D09.19D30.4D41.3D49.59
ejaculatory ductC63.7C79.82D07.69D29.8D40.8D49.59
endocervix (canal) (gland)C53.0C79.82D06.0D26.0D39.0D49.59
endometrium (gland) (stroma)C54.1C79.82D07.0D26.1D39.0D49.59
epididymisC63.0C79.82D07.69D29.3D40.8D49.59
exocervixC53.1C79.82D06.1D26.0D39.0D49.59
external › os, cervix uteriC53.1C79.82D06.1D26.0D39.0D49.59
fallopian tube (accessory)C57.0C79.82D07.39D28.2D39.8D49.59
fetal membraneC58C79.82D07.0D26.7D39.2D49.59
follicle, nabothianC53.0C79.82D06.0D26.0D39.0D49.59
foreskinC60.0C79.82D07.4D29.0D40.8D49.59
fornix › vaginaC52C79.82D07.2D28.1D39.8D49.59
fourchetteC51.9C79.82D07.1D28.0D39.8D49.59
fundus › uterusC54.3C79.82D07.0D26.1D39.0D49.59
Gartner's ductC52C79.82D07.2D28.1D39.8D49.59
genital organ or tract › female NECC57.9C79.82D07.30D28.9D39.9D49.59
genital organ or tract › female NEC › specified site NECC57.7C79.82D07.39D28.7D39.8D49.59
genital organ or tract › male NECC63.9C79.82D07.60D29.9D40.9D49.59
genital organ or tract › male NEC › specified site NECC63.7C79.82D07.69D29.8D40.8D49.59
genitourinary tract › femaleC57.9C79.82D07.30D28.9D39.9D49.59
genitourinary tract › maleC63.9C79.82D07.60D29.9D40.9D49.59
glans penisC60.1C79.82D07.4D29.0D40.8D49.59
hymenC52C79.82D07.2D28.1D39.8D49.59
internal › os (cervix)C53.0C79.82D06.0D26.0D39.0D49.59
isthmus uteriC54.0C79.82D07.0D26.1D39.0D49.59
junction › pelviuretericC65.C79.0D09.19D30.1D41.1D49.59
junction › squamocolumnar, of cervixC53.8C79.82D06.7D26.0D39.0D49.59
labia (skin)C51.9C79.82D07.1D28.0D39.8D49.59
labia (skin) › majoraC51.0C79.82D07.1D28.0D39.8D49.59
labia (skin) › minoraC51.1C79.82D07.1D28.0D39.8D49.59
labium (skin)C51.9C79.82D07.1D28.0D39.8D49.59
labium (skin) › majusC51.0C79.82D07.1D28.0D39.8D49.59
labium (skin) › minusC51.1C79.82D07.1D28.0D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › broadC57.1C79.82D07.39D28.2D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › Mackenrodt'sC57.7C79.82D07.39D28.7D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › roundC57.2C79.82–D28.2D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › sacro-uterineC57.3C79.82–D28.2D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › uterineC57.3C79.82–D28.2D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › utero-ovarianC57.7C79.82D07.39D28.2D39.8D49.59
ligament [See Also: Neoplasm, connective tissue] › uterosacralC57.3C79.82–D28.2D39.8D49.59
Mackenrodt's ligamentC57.7C79.82D07.39D28.7D39.8D49.59
mesosalpinxC57.1C79.82D07.39D28.2D39.8D49.59
mesovariumC57.1C79.82D07.39D28.2D39.8D49.59
mons › pubisC51.9C79.82D07.1D28.0D39.8D49.59
mons › venerisC51.9C79.82D07.1D28.0D39.8D49.59
Mullerian duct › femaleC57.7C79.82D07.39D28.7D39.8D49.59
Mullerian duct › maleC63.7C79.82D07.69D29.8D40.8D49.59
myometriumC54.2C79.82D07.0D26.1D39.0D49.59
nabothian gland (follicle)C53.0C79.82D06.0D26.0D39.0D49.59
os › externalC53.1C79.82D06.1D26.0D39.0D49.59
os › internalC53.0C79.82D06.0D26.0D39.0D49.59
ovaryC56.C79.6D07.39D27.D39.1D49.59
oviductC57.0C79.82D07.39D28.2D39.8D49.59
parametriumC57.3C79.82–D28.2D39.8D49.59
paraurethral › glandC68.1C79.19D09.19D30.8D41.8D49.59
paroophoronC57.1C79.82D07.39D28.2D39.8D49.59
parovariumC57.1C79.82D07.39D28.2D39.8D49.59
penisC60.9C79.82D07.4D29.0D40.8D49.59
penis › bodyC60.2C79.82D07.4D29.0D40.8D49.59
penis › corpus (cavernosum)C60.2C79.82D07.4D29.0D40.8D49.59
penis › glansC60.1C79.82D07.4D29.0D40.8D49.59
penis › skin NECC60.9C79.82D07.4D29.0D40.8D49.59
placentaC58C79.82D07.0D26.7D39.2D49.59
prepuceC60.0C79.82D07.4D29.0D40.8D49.59
prostate (gland)C61C79.82D07.5D29.1D40.0D49.59
prostate (gland) › utricleC68.0C79.19D09.19D30.4D41.3D49.59
pudenda, pudendum (femaie)C51.9C79.82D07.1D28.0D39.8D49.59
round ligamentC57.2C79.82–D28.2D39.8D49.59
sacrouterine ligamentC57.3C79.82–D28.2D39.8D49.59
salpinx (uterine)C57.0C79.82D07.39D28.2D39.8D49.59
scrotum (skin)C63.2C79.82D07.61D29.4D40.8D49.59
seminal vesicleC63.7C79.82D07.69D29.8D40.8D49.59
septum › urethrovaginalC57.9C79.82D07.30D28.9D39.9D49.59
septum › vesicovaginalC57.9C79.82D07.30D28.9D39.9D49.59
Skene's glandC68.1C79.19D09.19D30.8D41.8D49.59
skin NOS › clitorisC51.2C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external)C51.9C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › clitorisC51.2C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › labium NECC51.9C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › labium NEC › majusC51.0C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › labium NEC › minusC51.1C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › pudendumC51.9C79.82D07.1D28.0D39.8D49.59
skin NOS › female genital organs (external) › vulvaC51.9C79.82D07.1D28.0D39.8D49.59
skin NOS › labia › majoraC51.0C79.82D07.1D28.0D39.8D49.59
skin NOS › labia › minoraC51.1C79.82D07.1D28.0D39.8D49.59
skin NOS › male genital organsC63.9C79.82D07.60D29.9D40.8D49.59
skin NOS › male genital organs › penisC60.9C79.82D07.4D29.0D40.8D49.59
skin NOS › male genital organs › prepuceC60.0C79.82D07.4D29.0D40.8D49.59
skin NOS › male genital organs › scrotumC63.2C79.82D07.61D29.4D40.8D49.59
skin NOS › penis NECC60.9C79.82D07.4D29.0D40.8D49.59
skin NOS › prepuceC60.0C79.82D07.4D29.0D40.8D49.59
skin NOS › scrotumC63.2C79.82D07.61D29.4D40.8D49.59
skin NOS › vulvaC51.9C79.82D07.1D28.0D39.8D49.59
spermatic cordC63.1C79.82D07.69D29.8D40.8D49.59
stroma, endometrialC54.1C79.82D07.0D26.1D39.0D49.59
stump, cervicalC53.8C79.82D06.7D26.0D39.0D49.59
testis, testesC62.9C79.82D07.69D29.2D40.1D49.59
testis, testes › descendedC62.1C79.82D07.69D29.2D40.1D49.59
testis, testes › ectopicC62.0C79.82D07.69D29.2D40.1D49.59
testis, testes › retainedC62.0C79.82D07.69D29.2D40.1D49.59
testis, testes › scrotalC62.1C79.82D07.69D29.2D40.1D49.59
testis, testes › undescendedC62.0C79.82D07.69D29.2D40.1D49.59
testis, testes › unspecified whether descended or undescendedC62.9C79.82D07.69D29.2D40.1D49.59
tubo-ovarianC57.8C79.82D07.39D28.7D39.8D49.59
tunica vaginalisC63.7C79.82D07.69D29.8D40.8D49.59
ureter, ureteralC66.C79.19D09.19D30.2D41.2D49.59
urethra, urethral (gland)C68.0C79.19D09.19D30.4D41.3D49.59
urethrovaginal (septum)C57.9C79.82D07.30D28.9D39.8D49.59
urinary organ or systemC68.9C79.10D09.10D30.9D41.9D49.59
urinary organ or system › specified sites NECC68.8C79.19D09.19D30.8D41.8D49.59
utero-ovarianC57.8C79.82D07.39D28.7D39.8D49.59
utero-ovarian › ligamentC57.1C79.82D07.39D28.2D39.8D49.59
uterosacral ligamentC57.3C79.82–D28.2D39.8D49.59
uterus, uteri, uterineC55C79.82D07.0D26.9D39.0D49.59
uterus, uteri, uterine › adnexa NECC57.4C79.82D07.39D28.7D39.8D49.59
uterus, uteri, uterine › bodyC54.9C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › cervixC53.9C79.82D06.9D26.0D39.0D49.59
uterus, uteri, uterine › cornuC54.9C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › corpusC54.9C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › endocervix (canal) (gland)C53.0C79.82D06.0D26.0D39.0D49.59
uterus, uteri, uterine › endometriumC54.1C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › exocervixC53.1C79.82D06.1D26.0D39.0D49.59
uterus, uteri, uterine › external osC53.1C79.82D06.1D26.0D39.0D49.59
uterus, uteri, uterine › fundusC54.3C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › internal osC53.0C79.82D06.0D26.0D39.0D49.59
uterus, uteri, uterine › isthmusC54.0C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › ligamentC57.3C79.82–D28.2D39.8D49.59
uterus, uteri, uterine › ligament › broadC57.1C79.82D07.39D28.2D39.8D49.59
uterus, uteri, uterine › ligament › roundC57.2C79.82–D28.2D39.8D49.59
uterus, uteri, uterine › lower segmentC54.0C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › myometriumC54.2C79.82D07.0D26.1D39.0D49.59
uterus, uteri, uterine › squamocolumnar junctionC53.8C79.82D06.7D26.0D39.0D49.59
uterus, uteri, uterine › tubeC57.0C79.82D07.39D28.2D39.8D49.59
utricle, prostaticC68.0C79.19D09.19D30.4D41.3D49.59
vagina, vaginal (fornix) (vault) (wall)C52C79.82D07.2D28.1D39.8D49.59
vaginovesicalC57.9C79.82D07.30D28.9D39.9D49.59
vaginovesical › septumC57.9C79.82D07.30D28.9D39.9D49.59
vas deferensC63.1C79.82D07.69D29.8D40.8D49.59
vesicle, seminalC63.7C79.82D07.69D29.8D40.8D49.59
vesicocervical tissueC57.9C79.82D07.30D28.9D39.9D49.59
vesicovaginalC57.9C79.82D07.30D28.9D39.9D49.59
vesicovaginal › septumC57.9C79.82D07.30D28.9D39.8D49.59
vestibular gland, greaterC51.0C79.82D07.1D28.0D39.8D49.59
vulvaC51.9C79.82D07.1D28.0D39.8D49.59
vulvovaginal glandC51.0C79.82D07.1D28.0D39.8D49.59
wolffian (body) (duct) › femaleC57.7C79.82D07.39D28.7D39.8D49.59
wolffian (body) (duct) › maleC63.7C79.82D07.69D29.8D40.8D49.59

Convert D49.59 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
239.5 Other gu neoplasm NOS
Approximate The match is approximate rather than exact.

Code History & ChangesHistory

Replacement D49.59 replaces the following previously assigned code(s):

  • D49.5 - Neoplasm of unsp behavior of other genitourinary organs
FY 2019AddedAdded to the ICD-10-CM code setEffective October 1, 2018.
FY 2020–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D49.59Overview

What is the ICD-10 code for neoplasm of unspecified behavior of other genitourinary organ?

The ICD-10-CM code for neoplasm of unspecified behavior of other genitourinary organ is D49.59 (sometimes written as D4959). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D49.59 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of other genitourinary organ on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D49.59 group to?

When neoplasm of unspecified behavior of other genitourinary organ is the principal diagnosis on an inpatient stay, it groups to MS-DRG 656, 687, 658, 657, 686, 688, with relative weights from 0.7332 to 3.2782 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D49.59?

Under the General Equivalence Mappings, neoplasm of unspecified behavior of other genitourinary organ converts to ICD-9-CM 239.5 (other gu neoplasm NOS). The mapping is approximate, so confirm the match fits the documentation.