2026 ICD-10-CM Diagnosis Code C52Malignant neoplasm of vagina
ICD-10-CM Codes›C00–D49›C51-C58›C52
- Billable — Valid for Submission
- Risk Adjusts — HCC 22
- Chronic Condition
C52 is a billable ICD-10-CM diagnosis code for malignant neoplasm of vagina. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 736 through 741, 754 through 756. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female reproductive system cancers - vagina.
For Medicare Advantage risk adjustment, C52 maps to CMS-HCC Category 22 (Bladder, Colorectal, and Other Cancers) under the V28 model, adding a risk factor of about 0.363 for a community, non-dual, aged beneficiary in payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C52 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Carcinoma of vagina
- Malignant germ cell neoplasm of vagina
- Malignant neoplasm involving left fallopian tube by direct extension from vagina
- Malignant neoplasm involving right fallopian tube by direct extension from vagina
- Malignant neoplasm involving urinary bladder by direct extension from vagina
- Malignant neoplasm of Gartner's duct
- Malignant neoplasm of vagina
- Malignant neoplasm of vaginal vault
- Malignant tumor involving an organ by direct extension from vagina
- Malignant tumor involving left ovary by direct extension from vagina
- Malignant tumor involving rectum by direct extension from vagina
- Malignant tumor involving right ovary by direct extension from vagina
- Malignant tumor involving uterine cervix by direct extension from vagina
- Malignant tumor involving uterine corpus by direct extension from vagina
- Malignant tumor involving vulva by direct extension from vagina
- Primary adenocarcinoma of vagina
- Primary carcinoma of vagina
- Primary malignant melanoma of vagina
- Primary malignant neoplasm of vagina
- Primary squamous cell carcinoma of vagina
- Recurrent primary malignant neoplasm of vagina
- Sarcoma of vulva
- Squamous cell carcinoma of vagina
- Vaginal intraepithelial neoplasia
- Vulvovaginal rhabdomyosarcoma
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Type 1 Excludes
- carcinoma in situ of vagina D07.2
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
Patient EducationClinical
Vaginal Cancer
Vaginal cancer is a rare type of cancer that starts in the vagina. The vagina is the canal leading from your cervix (the opening of your uterus) to the outside of your body.
The full article covers:
- What is vaginal cancer?
- Who is more likely to develop vaginal cancer?
- What are the symptoms of vaginal cancer?
- How is vaginal cancer diagnosed?
- What are the treatments for vaginal cancer?
- Can vaginal cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C52 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C52Overview
What is the ICD-10 code for malignant neoplasm of vagina?
The ICD-10-CM code for malignant neoplasm of vagina is C52. It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is C52 (Malignant neoplasm of vagina) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of vagina on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C52 group to?
When malignant neoplasm of vagina is the principal diagnosis on an inpatient stay, it groups to MS-DRG 736, 737, 738, 739, 740, 741, 754, 755, 756, with relative weights from 0.9605 to 3.5745 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of C52?
Under the General Equivalence Mappings, malignant neoplasm of vagina converts to ICD-9-CM 184.0 (malign neopl vagina). The mapping is a direct match.
What HCC is C52?
C52 (malignant neoplasm of vagina) maps to CMS-HCC Category 22 (Bladder, Colorectal, and Other Cancers), commonly written as HCC 22, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 11 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does C52 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C52 adds a risk adjustment factor of about 0.363 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.314 to 0.410 depending on the payment segment). A more severe related category (HCC 17, HCC 18, HCC 19, HCC 20, and HCC 21) supersedes it when both are reported. See the full factor table on the HCC 22 category page.
