2026 ICD-10-CM Diagnosis Code C52

Malignant neoplasm of vagina

ICD-10-CM Code:
C52
ICD-10 Code for:
Malignant neoplasm of vagina
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

C52 is a billable diagnosis code used to specify a medical diagnosis of malignant neoplasm of vagina. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic fornix vagina or Neoplasm, neoplastic Gartner's duct or Neoplasm, neoplastic hymen or Neoplasm, neoplastic vagina, vaginal (fornix) (vault) (wall) .

Code Classification

  • Neoplasms
    C00–D49
    • Malignant neoplasms of female genital organs
      C51-C58
      • Malignant neoplasm of vagina
        C52

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Carcinoma of vagina
  • Malignant germ cell neoplasm of vagina
  • Malignant neoplasm involving left fallopian tube by direct extension from vagina
  • Malignant neoplasm involving right fallopian tube by direct extension from vagina
  • Malignant neoplasm involving urinary bladder by direct extension from vagina
  • Malignant neoplasm of Gartner's duct
  • Malignant neoplasm of vagina
  • Malignant neoplasm of vaginal vault
  • Malignant tumor involving an organ by direct extension from vagina
  • Malignant tumor involving left ovary by direct extension from vagina
  • Malignant tumor involving rectum by direct extension from vagina
  • Malignant tumor involving right ovary by direct extension from vagina
  • Malignant tumor involving uterine cervix by direct extension from vagina
  • Malignant tumor involving uterine corpus by direct extension from vagina
  • Malignant tumor involving vulva by direct extension from vagina
  • Primary adenocarcinoma of vagina
  • Primary carcinoma of vagina
  • Primary malignant melanoma of vagina
  • Primary malignant neoplasm of vagina
  • Primary squamous cell carcinoma of vagina
  • Recurrent primary malignant neoplasm of vagina
  • Sarcoma of vulva
  • Squamous cell carcinoma of vagina
  • Vaginal intraepithelial neoplasia
  • Vaginal intraepithelial neoplasia
  • Vaginal intraepithelial neoplasia
  • Vaginal intraepithelial neoplasia
  • Vulvovaginal rhabdomyosarcoma

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Female reproductive system cancers - vagina

CCSR Code: NEO037

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • carcinoma in situ of vagina D07.2

Convert C52 to ICD-9-CM

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

Malign neopl vagina

ICD-9-CM: 184.0

This is a direct match with no additional mapping qualifiers. The absence of a flag generally means the mapping is considered exact or precise. In other words, the ICD-10 code maps cleanly to the ICD-9 code without qualification, approximation, or needing multiple codes.

Table of Neoplasms

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
Primary
Malignant
Secondary
CaInSitu Benign Uncertain
Behavior
Unspecified
Behavior
»Neoplasm, neoplastic
  »fornix
    »vagina
C52C79.82D07.2D28.1D39.8D49.59
»Neoplasm, neoplastic
  »Gartner's duct
C52C79.82D07.2D28.1D39.8D49.59
»Neoplasm, neoplastic
  »hymen
C52C79.82D07.2D28.1D39.8D49.59
»Neoplasm, neoplastic
  »vagina, vaginal (fornix) (vault) (wall)
C52C79.82D07.2D28.1D39.8D49.59

Patient Education


Vaginal Cancer

What is vaginal cancer?

Vaginal cancer is a rare type of cancer that starts in the vagina. The vagina is the canal leading from your cervix (the opening of your uterus) to the outside of your body.

Who is more likely to develop vaginal cancer?

You are more likely to develop vaginal cancer if:

  • You're age 60 or older.
  • You've had certain types of human papillomavirus (HPV) infections.
  • You were exposed to a medicine called DES (diethylstilbestrol) before you were born. Between 1940-1971, DES was sometimes prescribed to prevent miscarriages. DES was later linked to different health problems, including vaginal cancer.
  • You have had abnormal cells in your vagina, cervix, or uterus.

What are the symptoms of vaginal cancer?

Vaginal cancer often doesn't have early symptoms. However, see your health care provider if you notice:

  • Vaginal bleeding that is not your period
  • A vaginal lump
  • Pelvic pain
  • Pain during sex
  • Pain while urinating (peeing)
  • Constipation or blood in your stool (poop) or urine (pee)

How is vaginal cancer diagnosed?

To find out if you have vaginal cancer, your provider will use tests that examine the vagina and other organs in your pelvis. These tests may include:

  • A pelvic exam. Your provider may also do a Pap test and/or an HPV test during your pelvic exam.
  • Colposcopy, a procedure to examine your cervix, vagina, and vulva.
  • Biopsy, a procedure to remove some cells so they can be checked for cancer.

What are the treatments for vaginal cancer?

Vaginal cancer can often be cured if it is found early. Treatments for vaginal cancer may include surgery, radiation therapy, and/or chemotherapy.

Can vaginal cancer be prevented?

Vaccines that protect against HPV infection may reduce your risk of vaginal cancer. The vaccines provide the most protection if you get them before you are exposed to HPV. So it's best to get vaccinated before you become sexually active.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Code History

  • FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026
  • FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025
  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.