2026 ICD-10-CM Diagnosis Code C58Malignant neoplasm of placenta
ICD-10-CM Codes›C00–D49›C51-C58›C58
- Billable — Valid for Submission
- Chronic Condition
ICD-10-CM C58
C58 is a billable ICD-10-CM diagnosis code for malignant neoplasm of placenta. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 736 through 741, 754 through 756. The code is restricted by the Medicare Code Editor to maternity cases (age 9 through 64). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Female reproductive system cancers - all other types.
Code Identity
ICD-10-CM Code
C58
Billable Status
Yes — Valid for Submission
Code Describes
Malignant neoplasm of placenta
Chapter
C51-C58
Malignant neoplasms of female genital organs
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for C58.
The Medicare Code Editor detects inconsistencies in maternity cases by checking a patient's age and any diagnosis on the patient's record. The maternity code edits apply to patients age ange is 9–64 years inclusive (e.g., diabetes in pregnancy, antepartum pulmonary complication).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Choriocarcinoma
- Choriocarcinoma of placenta
- Epithelioid trophoblastic tumor
- Gestational choriocarcinoma
- Gestational trophoblastic disease
- Gestational trophoblastic neoplasia
- Malignant neoplastic disease in pregnancy
- Neoplasm of placenta
- Primary malignant neoplasm of placenta
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Includes
- choriocarcinoma NOS
- chorionepithelioma NOS
Type 1 Excludes
- chorioadenoma destruens D39.2
- hydatidiform mole NOS O01.9
- invasive hydatidiform mole D39.2
- male choriocarcinoma NOS C62.9
- malignant hydatidiform mole D39.2
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Carcinoma (malignant) - See Also: Neoplasm, by site, malignant;
- female - C58
- Choriocarcinoma - See: Neoplasm, malignant, by site;
- female - C58
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Carcinoma(malignant)
- chorionic
- unspecified site
- female
- Choriocarcinoma
- unspecified site
- female
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
CCSR NEO038
Female reproductive system cancers - all other types
Default principal diagnosis: inpatient Yes · outpatient Yes
Clinical InformationClinical
Abruptio Placentae
premature separation of the normally implanted placenta from the uterus. signs of varying degree of severity include uterine bleeding, uterine muscle hypertonia, and fetal distress or fetal death.Annexin A3
a protein of the annexin family that catalyzes the conversion of 1-d-inositol 1,2-cyclic phosphate and water to 1-d-myo-inositol 1-phosphate.Annexin A4
protein of the annexin family originally isolated from the electric organ of the electric ray torpedo marmorata. it has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized epithelial cells.Annexin A5
a protein of the annexin family isolated from human placenta and other tissues. it inhibits cytosolic phospholipase a2, and displays anticoagulant activity.Cadherins
calcium-dependent cell adhesion proteins. they are important in the formation of adherens junctions between cells. cadherins are classified by their distinct immunological and tissue specificities, either by letters (e- for epithelial, n- for neural, and p- for placental cadherins) or by numbers (cadherin-12 or n-cadherin 2 for brain-cadherin). cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Chorionic Villi
threadlike vascular projections of the chorion. chorionic villi may be free or embedded within the decidua forming the site for exchange of substances between fetal and maternal blood (placenta).Cord Blood Stem Cell Transplantation
transplantation of stem cells collected from the fetal blood remaining in the umbilical cord and the placenta after delivery. included are the hematopoietic stem cells.Eutheria
mammals which nourish their young in utero by means of a complex placenta, and give birth to their young alive. they include primates; carnivora, whales; ruminants; bats; and rodents.Folate Receptor 2
a subtype of gpi-anchored folate receptors that is expressed in placenta and hematopoietic cells.Ichthyosis, X-Linked
chronic form of ichthyosis that is inherited as a sex-linked recessive trait carried on the x-chromosome and transmitted to the male offspring. it is characterized by severe scaling, especially on the extremities, and is associated with steroid sulfatase deficiency.Perilipin-3
a perilipin that localizes to lipid droplets; cytoplasm; endosomes; and plasma membrane, especially in macrophages. it functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. it is also required for the transport of the mannose-6-phosphate receptor from endosomes to the trans-golgi network. its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.Placenta
a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. it includes a fetal portion (chorionic villi) derived from trophoblasts and a maternal portion (decidua) derived from the uterine endometrium. the placenta produces an array of steroid, protein and peptide hormones (placental hormones).Placenta Accreta
abnormal placentation in which all or parts of the placenta are attached directly to the myometrium due to a complete or partial absence of decidua. it is associated with postpartum hemorrhage because of the failure of placental separation.Placenta Diseases
pathological processes or abnormal functions of the placenta.Placenta Growth Factor
an angiogenic protein belonging to the vascular endothelial growth factor family of growth factors originally isolated and cloned from human placental cdna library. there are four isoforms of plgf 1-4 which result from alternative splicing. placenta growth factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.Placenta Previa
abnormal placentation in which the placenta implants in the lower segment of the uterus (the zone of dilation) and may cover part or all of the opening of the cervix. it is often associated with serious antepartum bleeding and premature labor.Placenta, Retained
a placenta that fails to be expelled after birth of the fetus. a placenta is retained when the uterus fails to contract after the delivery of its content, or when the placenta is abnormally attached to the myometrium.Placental Circulation
the circulation of blood, of both the mother and the fetus, through the placenta.Placental Extracts
extracts prepared from placental tissue; they may contain specific but uncharacterized factors or proteins with specific activities.Placental Function Tests
methods used for the assessment of placental function.Placental Hormones
hormones produced by the placenta include chorionic gonadotropin, and placental lactogen as well as steroids (estrogens; progesterone), and neuropeptide hormones similar to those found in the hypothalamus (hypothalamic hormones).Placental Insufficiency
failure of the placenta to deliver an adequate supply of nutrients and oxygen to the fetus.Placental Lactogen
a polypeptide hormone of approximately 25 kda that is produced by the syncytiotrophoblasts of the placenta, also known as chorionic somatomammotropin. it has both growth hormone and prolactin activities on growth, lactation, and luteal steroid production. in women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. placental lactogen is also an insulin antagonist.Placentation
the development of the placenta, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and fetus. the process begins at fertilization, through the development of cytotrophoblasts and syncytiotrophoblasts, the formation of chorionic villi, to the progressive increase in blood vessels to support the growing fetus.Plasminogen Inactivators
important modulators of the activity of plasminogen activators. the inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.Pregnancy Proteins
proteins produced by organs of the mother or the placenta during pregnancy. these proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)Pregnancy Trimester, First
the beginning third of a human pregnancy, from the first day of the last normal menstrual period (menstruation) through the completion of 14 weeks (98 days) of gestation.S100 Calcium-Binding Protein A4
an s100 protein characterized by four helix bundles that form n- and c-terminal ef hand motifs. it functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. aberrant s100a4 activity is associated with neoplasm metastasis; fibrosis; and rheumatoid arthritis.Trophoblastic Tumor, Placental Site
an uncommon variant of choriocarcinoma. it is composed almost entirely of mononuclear cytotrophoblasts (trophoblasts). because its secretion of hcg (chorionic gonadotropin) is low, a large tumor may develop before the hcg can be detected.Umbilical Cord Clamping
method of placing clamps on the umbilical cord before cutting after birth.Choriocarcinoma
a malignant metastatic form of trophoblastic tumors. unlike the hydatidiform mole, choriocarcinoma contains no chorionic villi but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (trophoblasts). it is characterized by the large amounts of chorionic gonadotropin produced. tissue origins can be determined by dna analyses: placental (fetal) origin or non-placental origin (choriocarcinoma, non-gestational).Choriocarcinoma, Non-gestational
a highly malignant choriocarcinoma derived from the non-placental origin such as the totipotent cells in the testis, the ovary, and the pineal gland. it produces high levels of chorionic gonadotropin and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.Gestational Trophoblastic Disease
a group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (trophoblast) and markedly elevated human chorionic gonadotropin. they include hydatidiform mole, invasive mole (hydatidiform mole, invasive), placental-site trophoblastic tumor (trophoblastic tumor, placental site), and choriocarcinoma. these neoplasms have varying propensities for invasion and spread.Fallopian Tube Gestational Choriocarcinoma|Gestational Choriocarcinoma of Fallopian Tube|Gestational Choriocarcinoma of the Fallopian Tube
a malignant trophoblastic tumor that arises from the fallopian tube during pregnancy.Gestational Choriocarcinoma
a rare, highly malignant epithelial tumor that develops from a hydatidiform mole (50%), following abortion (25%), or during normal pregnancy (22%). it is characterized by the presence of invasive and anaplastic trophoblastic tissue composed of intermediate trophoblastic cells, cytotrophoblasts and syncytiotrophoblasts, abundant vascularity, and secretion of human chorionic gonadotropin. because of rapid growth and a high propensity for hemorrhage, this neoplasm often constitutes a medical emergency.Ovarian Gestational Choriocarcinoma|Gestational Ovarian Choriocarcinoma
a rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. there is no germ cell component present.Uterine Corpus Choriocarcinoma|Gestational Uterine Corpus Choriocarcinoma|Uterine Corpus Gestational Choriocarcinoma
an aggressive malignant tumor arising from trophoblastic cells in the uterus during pregnancy. approximately half of the cases develop from a complete hydatidiform mole. there is often marked elevation of human chorionic gonadotropin (hcg) in the blood. choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
Table of NeoplasmsClinical
Patient EducationClinical
Tumors and Pregnancy
Tumors during pregnancy are rare, but they can happen. Tumors can be either benign (not cancer) or malignant (cancer). The most common cancers in pregnancy include breast cancer, thyroid cancer, cervical cancer, lymphoma, and melanoma. Cancer itself rarely harms the fetus, and some cancer treatments are safe during pregnancy.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C58 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.
Questions About C58Overview
Is C58 (Malignant neoplasm of placenta) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of placenta on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C58 group to?
When malignant neoplasm of placenta is the principal diagnosis on an inpatient stay, it groups to MS-DRG 736, 737, 738, 739, 740, 741, 754, 755, 756, with relative weights from 0.9605 to 3.5745 depending on complications. Higher weights mean higher Medicare reimbursement.
Who can C58 be reported for?
The Medicare Code Editor checks malignant neoplasm of placenta against patient demographics: this code is intended for maternity cases (age 9 through 64). Claims outside these limits are flagged as inconsistent.
What is the ICD-9 equivalent of C58?
Under the General Equivalence Mappings, malignant neoplasm of placenta converts to ICD-9-CM 181 (malignant neopl placenta). The mapping is a direct match.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
