2027 ICD-10-CM Diagnosis Code D48.60Neoplasm of uncertain behavior of unspecified breast
ICD-10-CM Codes›C00–D49›D37-D48›D48
- Billable — Valid for Submission
- Not Chronic
D48.60 is a billable ICD-10-CM diagnosis code for neoplasm of uncertain behavior of unspecified breast. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 582 through 583, 597 through 599. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Aggressive fibromatosis of breast
- Neoplasm of areola
- Neoplasm of ectopic site of breast
- Neoplasm of uncertain behavior of areola
- Neoplasm of uncertain behavior of axillary tail of breast
- Neoplasm of uncertain behavior of breast
- Neoplasm of uncertain behavior of central portion of breast
- Neoplasm of uncertain behavior of ectopic site of breast
- Neoplasm of uncertain behavior of lower inner quadrant of breast
- Neoplasm of uncertain behavior of lower outer quadrant of breast
- Neoplasm of uncertain behavior of nipple
- Neoplasm of uncertain behavior of upper inner quadrant of breast
- Neoplasm of uncertain behavior of upper outer quadrant of breast
- Phyllodes tumor of breast
- Phyllodes tumor of breast, borderline
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D48.60: its own notes plus those printed at D48.6, D48, block D37-D48, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- neoplasm of uncertain behavior of skin of breast (D48.5)
- neurofibromatosis (nonmalignant) (Q85.0-)
- neoplasms of unspecified behavior (D49.-)
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D48.60, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming D48.60: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 1
These codes carry an Excludes2 note naming D48.60: its condition is not part of those codes, and both may be reported when the patient has both.
Notes 1
These notes mention D48.60.
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesCategories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. names D48, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Phyllodes Tumor
a type of connective tissue neoplasm typically arising from intralobular stroma of the breast. it is characterized by the rapid enlargement of an asymmetric firm mobile mass. histologically, its leaf-like stromal clefts are lined by epithelial cells. rare phyllodes tumor of the prostate is also known.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) | C50.9 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › areola | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › axillary tail | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › central portion | C50.1 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › inner | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-inner quadrant | C50.3 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › lower-outer quadrant | C50.5 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › midline | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › nipple | C50.0 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › outer | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › tail (axillary) | C50.6 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper | C50.8 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-inner quadrant | C50.2 | C79.81 | D05. | D24. | D48.6 | D49.3 |
| breast (connective tissue) (glandular tissue) (soft parts) › upper-outer quadrant | C50.4 | C79.81 | D05. | D24. | D48.6 | D49.3 |
Patient EducationClinical
Breast Diseases
Breast diseases include various conditions and changes in your breast. Most women experience breast changes at some time. Your age, hormone levels, and medicines you take may cause lumps, bumps, and discharges of fluids that are not breast milk.
The full article covers:
- What are breast diseases?
- What are the symptoms of breast disease?
- How are breast diseases diagnosed?
- What are the treatments for breast disease?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D48.60 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D48.60Overview
What is the ICD-10 code for neoplasm of uncertain behavior of unspecified breast?
The ICD-10-CM code for neoplasm of uncertain behavior of unspecified breast is D48.60 (sometimes written as D4860). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D48.60 (Neoplasm of uncertain behavior of breast) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of uncertain behavior of unspecified breast on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D48.60 group to?
When neoplasm of uncertain behavior of unspecified breast is the principal diagnosis on an inpatient stay, it groups to MS-DRG 598, 582, 599, 597, 583, with relative weights from 0.6756 to 1.8014 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D48.60 be reported with D48.5?
Not as a rule. The Excludes1 note at D48.6, which applies to D48.60, lists "neoplasm of uncertain behavior of skin of breast (D48.5)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D48.60?
Under the General Equivalence Mappings, neoplasm of uncertain behavior of unspecified breast converts to ICD-9-CM 238.3 (unc behav neo breast). The mapping is approximate, so confirm the match fits the documentation.
