2027 ICD-10-CM Diagnosis Code D48.5Neoplasm of uncertain behavior of skin

Billable — Valid for Submission
Not Chronic

ICD-10-CM D48.5

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D48.5 is a billable ICD-10-CM diagnosis code for neoplasm of uncertain behavior of skin. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 606 through 607. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code

D48.5

Billable Status

Yes — Valid for Submission

Code Describes

Neoplasm of uncertain behavior of skin

Short Description

Neoplasm of uncertain behavior of skin

Same as the full description in the CMS dataset.

Parent Code

D48

Neoplasm of uncertain behavior of other and unspecified sites

Code Classification

ChapterC00–D49Neoplasms

SectionD37-D48Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

CategoryD48Neoplasm of uncertain behavior of other and unspecified sites

This CodeD48.5Neoplasm of uncertain behavior of skin

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Filter synonyms:

Aggressive fibromatosis of skin
Angiomatoid fibrous histiocytoma
Angiomatoid fibrous histiocytoma of skin
Apudoma
Apudoma of skin
Atypical fibrous histiocytoma of soft tissue
Atypical fibroxanthoma of skin
Atypical fibroxanthoma of skin of neck
Atypical fibroxanthoma of skin of scalp
Giant cell fibroblastoma of skin
Giant pigmented nevus of skin
Hemangioblastoma of skin
Hemangioblastoma of soft tissue
Hemangioendothelioma
Hemangioendothelioma of skin
Lymphangioleiomyomatosis of skin
Melanocytic neoplasm of skin
Neoplasm of skin of ankle
Neoplasm of skin of axilla
Neoplasm of skin of buttock
Neoplasm of skin of elbow
Neoplasm of skin of eyebrow
Neoplasm of skin of finger
Neoplasm of skin of forearm
Neoplasm of skin of groin
Neoplasm of skin of lower leg
Neoplasm of skin of popliteal area
Neoplasm of skin of thigh
Neoplasm of skin of toe
Neoplasm of skin of umbilicus
Neoplasm of skin of upper arm
Neoplasm of skin of wrist
Neoplasm of uncertain behavior of adnexa of skin
Neoplasm of uncertain behavior of axilla
Neoplasm of uncertain behavior of cheek
Neoplasm of uncertain behavior of chest wall
Neoplasm of uncertain behavior of ear
Neoplasm of uncertain behavior of forearm
Neoplasm of uncertain behavior of inguinal region
Neoplasm of uncertain behavior of jaw
Neoplasm of uncertain behavior of lip
Neoplasm of uncertain behavior of lower leg
Neoplasm of uncertain behavior of nose
Neoplasm of uncertain behavior of ocular adnexa
Neoplasm of uncertain behavior of perianal skin
Neoplasm of uncertain behavior of sebaceous gland
Neoplasm of uncertain behavior of skin
Neoplasm of uncertain behavior of skin of abdomen
Neoplasm of uncertain behavior of skin of ankle
Neoplasm of uncertain behavior of skin of axilla
Neoplasm of uncertain behavior of skin of back
Neoplasm of uncertain behavior of skin of breast
Neoplasm of uncertain behavior of skin of buttock
Neoplasm of uncertain behavior of skin of cheek
Neoplasm of uncertain behavior of skin of chest
Neoplasm of uncertain behavior of skin of chin
Neoplasm of uncertain behavior of skin of ear
Neoplasm of uncertain behavior of skin of elbow
Neoplasm of uncertain behavior of skin of external auditory canal
Neoplasm of uncertain behavior of skin of eyebrow
Neoplasm of uncertain behavior of skin of eyelid
Neoplasm of uncertain behavior of skin of face
Neoplasm of uncertain behavior of skin of finger
Neoplasm of uncertain behavior of skin of foot
Neoplasm of uncertain behavior of skin of forearm
Neoplasm of uncertain behavior of skin of forehead
Neoplasm of uncertain behavior of skin of groin
Neoplasm of uncertain behavior of skin of hand
Neoplasm of uncertain behavior of skin of hip
Neoplasm of uncertain behavior of skin of knee
Neoplasm of uncertain behavior of skin of lip
Neoplasm of uncertain behavior of skin of lower leg
Neoplasm of uncertain behavior of skin of lower limb
Neoplasm of uncertain behavior of skin of neck
Neoplasm of uncertain behavior of skin of nose
Neoplasm of uncertain behavior of skin of perineum
Neoplasm of uncertain behavior of skin of popliteal area
Neoplasm of uncertain behavior of skin of scalp
Neoplasm of uncertain behavior of skin of shoulder
Neoplasm of uncertain behavior of skin of temporal region
Neoplasm of uncertain behavior of skin of thigh
Neoplasm of uncertain behavior of skin of toe
Neoplasm of uncertain behavior of skin of trunk
Neoplasm of uncertain behavior of skin of umbilicus
Neoplasm of uncertain behavior of skin of upper arm
Neoplasm of uncertain behavior of skin of upper limb
Neoplasm of uncertain behavior of skin of wrist
Neoplasm of uncertain behavior of soft tissues of axilla
Neoplasm of uncertain behavior of soft tissues of buttock
Neoplasm of uncertain behavior of soft tissues of hip
Neoplasm of uncertain behavior of soft tissues of neck
Neoplasm of uncertain behavior of soft tissues of pelvis
Neoplasm of uncertain behavior of soft tissues of perineum
Neoplasm of uncertain behavior of sweat gland
Neoplasm of uncertain behavior of thigh
Neoplasm of uncertain behavior of upper arm
OSSN - ocular surface squamous neoplasia
Papillary intralymphatic angioendothelioma
Papillary intralymphatic angioendothelioma of childhood
Pigmented epithelioid melanocytoma
Plexiform fibrohistiocytic tumor
Plexiform fibrohistiocytic tumor of skin
Solitary fibrous tumor
Solitary fibrous tumor of skin
Spitzoid neoplasm of uncertain malignant potential

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D48.5: its own notes plus those printed at D48, block D37-D48, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

Neoplasm of uncertain behavior of anal margin
Neoplasm of uncertain behavior of anal skin
Neoplasm of uncertain behavior of perianal skin
Neoplasm of uncertain behavior of skin of breast

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On D48.5 itself

neoplasm of uncertain behavior of anus NOS (D37.8)
neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8)
neoplasm of uncertain behavior of vermilion border of lip (D37.0)

From D48 Neoplasm of uncertain behavior of other and unspecified sites applies to 21 codes

neurofibromatosis (nonmalignant) (Q85.0-)

From Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes applies to 137 codes

neoplasms of unspecified behavior (D49.-)

Notes

General instructions on how these codes are used.

From Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes applies to 137 codes

Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes

Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D48.5, its category, or a range that includes it.

Excludes1 8

These codes carry an Excludes1 note naming D48.5: they are not reported together with it, unless the two conditions are unrelated.

D37.0 Neoplasm of uncertain behavior of lip, oral cavity and pharynx
neoplasm of uncertain behavior of skin of lip (D48.5)
D37.8 Neoplasm of uncertain behavior of other specified digestive organs
neoplasm of uncertain behavior of anal margin (D48.5)
D37.8 Neoplasm of uncertain behavior of other specified digestive organs
neoplasm of uncertain behavior of anal skin (D48.5)
D37.8 Neoplasm of uncertain behavior of other specified digestive organs
neoplasm of uncertain behavior of perianal skin (D48.5)
D38.5 Neoplasm of uncertain behavior of other respiratory organs
neoplasm of uncertain behavior of ear (external) (skin) (D48.5)
D38.5 Neoplasm of uncertain behavior of other respiratory organs
neoplasm of uncertain behavior of skin of nose (D48.5)
D48.6 Neoplasm of uncertain behavior of breast
neoplasm of uncertain behavior of skin of breast (D48.5)
D48.7 Neoplasm of uncertain behavior of other specified sites
neoplasm of uncertain behavior of skin of eyelid (D48.5)

Excludes2 1

These codes carry an Excludes2 note naming D48.5: its condition is not part of those codes, and both may be reported when the patient has both.

D49 Neoplasms of unspecified behavior
neoplasms of uncertain behavior (D37-D44, D48) names D48, which includes this code

Notes 1

These notes mention D48.5.

Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. names D48, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Nevus D22.9
- bathing trunk D48.5
- pigmented
  - giant See Also: Neoplasm, skin, uncertain behavior; D48.5

Tumor See Also: Neoplasm, unspecified behavior, by site;
- basal cell See Also: Neoplasm, skin, uncertain behavior; D48.5

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072

Neoplasms of unspecified nature or uncertain behavior

Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

Filter table of neoplasms:

Site	Malig. Primary	Malig. Secondary	Ca in situ	Benign	Uncertain	Unspec.
abdomen, abdominal › wall [See Also: Neoplasm, abdomen, wall, skin]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
ala nasi (external) [See Also: Neoplasm, skin, nose]	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
anus, anal › margin [See Also: Neoplasm, anus, skin]	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
anus, anal › skin	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
auditory › canal (external) (skin)	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
auricle, ear [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
auricular canal (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
axilla, axillary › fold [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
breast (connective tissue) (glandular tissue) (soft parts) › skin	C44.501	C79.2	D04.5	D23.5	D48.5	D49.2
brow	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
canal › auditory (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
canal › auricular (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
canthus (eye) (inner) (outer)	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
cheek › external	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
chin	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
columnella [See Also: Neoplasm, skin, face]	C44.390	C79.2	D04.39	D23.39	D48.5	D49.2
concha [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
connective tissue NEC › skin (dermis) NEC [See Also: Neoplasm, skin, by site]	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear] › auricle or auris [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear] › canal, external [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear] › external meatus [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear] › lobule [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
ear (external) [See Also: Neoplasm, skin, ear] › skin	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
earlobe	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
external › meatus (ear) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
eyebrow	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
forehead (skin)	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
helix [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
jaw › skin [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
lid (lower) (upper)	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
lip › skin (commissure) (lower) (upper)	C44.00	C79.2	D04.0	D23.0	D48.5	D49.2
meatus external (ear) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
meibomian gland	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
nail [See Also: Neoplasm, skin, limb]	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
nail [See Also: Neoplasm, skin, limb] › finger [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
nail [See Also: Neoplasm, skin, limb] › toe [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
nasolabial groove [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
nates [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
nose, nasal › ala (external) (nasi) [See Also: Neoplasm, nose, skin]	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
nose, nasal › external (skin) [See Also: Neoplasm, nose, skin]	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
nose, nasal › skin	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
palpebra	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
perianal (skin) [See Also: Neoplasm, anus, skin]	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
pinna (ear) NEC [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
scalp	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
scar NEC [See Also: Neoplasm, skin, by site]	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
skin NOS	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
skin NOS › abdominal wall	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › ala nasi [See Also: Neoplasm, nose, skin]	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › ankle [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › antecubital space [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › anus	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › arm [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › auditory canal (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › auricle (ear) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › auricular canal (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › axilla, axillary fold [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › back [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › breast	C44.501	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › brow [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › buttock [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › calf [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › canthus (eye) (inner) (outer)	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
skin NOS › cervical region [See Also: Neoplasm, skin, neck]	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
skin NOS › cheek (external) [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › chest (wall) [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › chin [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › clavicular area [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › columnella [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › concha [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › ear (external)	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › elbow [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › eyebrow [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › eyelid	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
skin NOS › face NOS	C44.300	C79.2	D04.30	D23.30	D48.5	D49.2
skin NOS › finger [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › flank [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › foot [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › forearm [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › forehead [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › glabella [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › gluteal region [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › groin [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › hand [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › head NEC [See Also: Neoplasm, skin, scalp]	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
skin NOS › heel [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › helix [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › hip [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › infraclavicular region [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › inguinal region [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › jaw [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › knee [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › leg [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › lid (lower) (upper)	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
skin NOS › limb NEC	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
skin NOS › limb NEC › lower	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › limb NEC › upper	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › lip (lower) (upper)	C44.00	C79.2	D04.0	D23.0	D48.5	D49.2
skin NOS › meatus, acoustic (external) [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › nates [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › neck	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
skin NOS › nose (external) [See Also: Neoplasm, nose, skin]	C44.301	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › palm [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › palpebra	C44.10	C79.2	D04.1	D23.1	D48.5	D49.2
skin NOS › perianal [See Also: Neoplasm, skin, anus]	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › perineum [See Also: Neoplasm, skin, anus]	C44.500	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › pinna [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › plantar [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › popliteal fossa or space [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › pubes [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › sacrococcygeal region [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › scalp	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
skin NOS › scapular region [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › shoulder [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › sole (foot) [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › specified sites NEC	C44.80	C79.2	D04.8	D23.9	D48.5	D49.2
skin NOS › submammary fold [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › supraclavicular region [See Also: Neoplasm, skin, neck]	C44.40	C79.2	D04.4	D23.4	D48.5	D49.2
skin NOS › temple [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
skin NOS › thigh [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › thoracic wall [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › thumb [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
skin NOS › toe [See Also: Neoplasm, skin, limb, lower]	C44.70	C79.2	D04.7	D23.7	D48.5	D49.2
skin NOS › tragus [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
skin NOS › trunk	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › umbilicus [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2
skin NOS › wrist [See Also: Neoplasm, skin, limb, upper]	C44.60	C79.2	D04.6	D23.6	D48.5	D49.2
sudoriferous, sudoriparous gland, site unspecified	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
sweat gland (apocrine) (eccrine), site unspecified	C44.90	C79.2	D04.9	D23.9	D48.5	D49.2
temple (skin) [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
temporal › region › skin [See Also: Neoplasm, skin, face]	C44.309	C79.2	D04.39	D23.39	D48.5	D49.2
tragus [See Also: Neoplasm, skin, ear]	C44.20	C79.2	D04.2	D23.2	D48.5	D49.2
umbilicus, umbilical [See Also: Neoplasm, skin, trunk]	C44.509	C79.2	D04.5	D23.5	D48.5	D49.2

Patient EducationClinical

Skin Conditions

Your skin is your body's largest organ. It covers the entire outside of your body. There are many ways that your skin protects your body and helps keep you healthy. For example, it:

The full article covers:

What does your skin do?
What problems and conditions can affect your skin?
How can I keep my skin healthy?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D48.5 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM

238.2 Unc behav neo skin

Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.

FY 2017–2026No changes

FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D48.5Overview

What is the ICD-10 code for neoplasm of uncertain behavior of skin?

The ICD-10-CM code for neoplasm of uncertain behavior of skin is D48.5 (sometimes written as D485). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D48.5 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of uncertain behavior of skin on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D48.5 group to?

When neoplasm of uncertain behavior of skin is the principal diagnosis on an inpatient stay, it groups to MS-DRG 607, 606, with relative weights from 0.8772 to 1.5721 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D48.5 be reported with D37.8?

Not as a rule. The Excludes1 note on D48.5 lists "neoplasm of uncertain behavior of anus NOS (D37.8)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of D48.5?

Under the General Equivalence Mappings, neoplasm of uncertain behavior of skin converts to ICD-9-CM 238.2 (unc behav neo skin). The mapping is a direct match.

Indicator	Meaning	CMS pays CC/MCC DRG
Y	Diagnosis was present at the time of inpatient admission	Yes
N	Diagnosis was not present at the time of admission	No
U	Documentation is insufficient to determine	No
W	Clinically undetermined	Yes
1	Unreported, exempt from POA reporting	No