ICD-10 Diagnosis Code E27.1

Primary adrenocortical insufficiency

Diagnosis Code E27.1

ICD-10: E27.1
Short Description: Primary adrenocortical insufficiency
Long Description: Primary adrenocortical insufficiency
This is the 2017 version of the ICD-10-CM diagnosis code E27.1

Code Classification
  • Endocrine, nutritional and metabolic diseases
    • Disorders of other endocrine glands (E20-E35)
      • Other disorders of adrenal gland (E27)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code E27.1 is grouped in the following Diagnostic Related Group(s) (MS-DRG v33.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Addison's disease
  • Addison's disease due to autoimmunity
  • Buccal pigmentation due to Addison's disease
  • Congenital primary adrenocortical hypofunction
  • Endocrine myopathy
  • Hereditary adrenal unresponsiveness to corticotropin
  • Hypermelanosis due to endocrine disorder
  • Myopathy in Addison's disease
  • Primary adrenocortical insufficiency

Index of Diseases and Injuries
References found for the code E27.1 in the Index of Diseases and Injuries:

Information for Patients

Addison Disease

Also called: Adrenal insufficiency, Adrenocortical hypofunction, Hypocortisolism

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • ACTH (cosyntropin) stimulation test
  • ACTH blood test
  • Acute adrenal crisis
  • Addison disease
  • Cortisol level

[Read More]

Autoimmune Addison disease Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.The signs and symptoms of autoimmune Addison disease can begin at any time, although they most commonly begin between ages 30 and 50. Common features of this condition include extreme tiredness (fatigue), nausea, decreased appetite, and weight loss. In addition, many affected individuals have low blood pressure (hypotension), which can lead to dizziness when standing up quickly; muscle cramps; and a craving for salty foods. A characteristic feature of autoimmune Addison disease is abnormally dark areas of skin (hyperpigmentation), especially in regions that experience a lot of friction, such as the armpits, elbows, knuckles, and palm creases. The lips and the inside lining of the mouth can also be unusually dark. Because of an imbalance of hormones involved in development of sexual characteristics, women with this condition may lose their underarm and pubic hair.Other signs and symptoms of autoimmune Addison disease include low levels of sugar (hypoglycemia) and sodium (hyponatremia) and high levels of potassium (hyperkalemia) in the blood. Affected individuals may also have a shortage of red blood cells (anemia) and an increase in the number of white blood cells (lymphocytosis), particularly those known as eosinophils (eosinophilia).Autoimmune Addison disease can lead to a life-threatening adrenal crisis, characterized by vomiting, abdominal pain, back or leg cramps, and severe hypotension leading to shock. The adrenal crisis is often triggered by a stressor, such as surgery, trauma, or infection.Individuals with autoimmune Addison disease or their family members often have another autoimmune disorder, most commonly autoimmune thyroid disease or type 1 diabetes.
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