ICD-10 Code T50.995

Adverse effect of other drugs, medicaments and biological substances

Version 2019 Replaced Code Non-Billable Code Adverse Effect

Not Valid for Submission

T50.995 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of other drugs, medicaments and biological substances. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10: T50.995
Short Description:Adverse effect of drug/meds/biol subst
Long Description:Adverse effect of other drugs, medicaments and biological substances

Consider the following ICD-10 codes with a higher level of specificity:

  • T50.995A - Adverse effect of other drugs, medicaments and biological substances, initial encounter
  • T50.995D - Adverse effect of other drugs, medicaments and biological substances, subsequent encounter
  • T50.995S - Adverse effect of other drugs, medicaments and biological substances, sequela

Replaced Code

This code was replaced in the 2020 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2019. This code was replaced for the FY 2020 (October 1, 2019 - September 30, 2020).

  • K59.03 - Drug induced constipation

Code Classification

  • Injury, poisoning and certain other consequences of external causes (S00–T98)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50)
      • Diuretics and oth and unsp drug/meds/biol subst (T50)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (first year ICD-10-CM implemented into the HIPAA mandated code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Medical Professionals


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acitretin adverse reaction
  • Adverse cutaneous reaction to aromatherapy
  • Adverse cutaneous reaction to chinese traditional herbal medicine
  • Adverse cutaneous reaction to herbal medicine
  • Adverse cutaneous reaction to homeopathic medicine
  • Adverse reaction caused by bisphosphonate
  • Adverse reaction to bone resorption inhibitor
  • Adverse reaction to drug acting on bone metabolism
  • Adverse reaction to drug primarily acting on nutrition
  • Adverse reaction to fatty acid
  • Adverse reaction to inorganic chemical
  • Adverse reaction to lipotropic drugs
  • Adverse reaction to oil
  • Adverse reaction to parathyroid and parathyroid derivatives
  • Adverse reaction to phosphodiesterase 5 inhibitor
  • Alcohol metabolism modifier adverse reaction
  • Anionic surfactant adverse reaction
  • Base adverse reaction
  • Bile agent adverse reaction
  • Bile agent adverse reaction
  • Bufexamac adverse reaction
  • Calcitonin adverse reaction
  • Calcitonin adverse reaction
  • Calcium polystyrene sulfonate adverse reaction
  • Calcium regulating agent adverse reaction
  • Calcium regulating hormone adverse reaction
  • Calcium regulating hormone adverse reaction
  • Carbomer-940 adverse reaction
  • Cation exchange resin adverse reaction
  • Cellulose-derived viscosity modifier adverse reaction
  • Chenodeoxycholic acid adverse reaction
  • Chenodeoxycholic and ursodeoxycholic acid adverse reaction
  • Chronic drug-induced renal disease
  • Citrate adverse reaction
  • Colchicum alkaloid adverse reaction
  • Collagen adverse reaction
  • Colony stimulating factors adverse reaction
  • Dimethyl-ether propane adverse reaction
  • Disinfectants and cleansers adverse reaction
  • Disodium etidronate adverse reaction
  • Disodium etidronate and calcium carbonate adverse reaction
  • Drug for the treatment of gout adverse reaction
  • Drug for the treatment of gout adverse reaction
  • Drug reaction with eosinophilia and systemic symptoms
  • Drug reaction with eosinophilia and systemic symptoms caused by strontium ranelate
  • Drug-induced anaphylactoid reaction
  • Drug-induced uveitis
  • Ear wax removal preparation adverse reaction
  • Enbucrilate adverse reaction
  • Ergoline drug adverse reaction
  • Etretinate adverse reaction
  • Filgrastim adverse reaction
  • Fixed oil adverse reaction
  • Fluoride adverse reaction
  • Gold nephropathy
  • Hemostatic adverse reaction
  • Herbal medicine adverse reaction
  • Homeopathic medicine adverse reaction
  • Immunostimulant adverse reaction
  • Inositol adverse reaction
  • Ion exchange resin adverse reaction
  • Isotretinoin adverse reaction
  • Lenograstim adverse reaction
  • Methyl methacrylate embolism
  • Molgramostim adverse reaction
  • Nephropathy induced by heavy metals
  • Nicotine adverse reaction
  • Non-ionic surfactant adverse reaction
  • Oral leukoplakia caused by sanguinarine
  • Osteonecrosis of jaw caused by drug
  • Osteonecrosis of jaw due to bisphosphonate
  • Pamidronic acid-induced uveitis
  • p-di-Isobutylphenoxypolyethoxyethanol adverse reaction
  • Peripheral/cerebral vasodilator adverse reaction
  • Phosphodiesterase inhibitor adverse reaction
  • Radiopharmaceutical adverse reaction
  • Retinoid adverse reaction
  • Retinoid adverse reaction
  • Retinoid adverse reaction
  • Retinopathy caused by canthaxanthin
  • Salmon calcitonin adverse reaction
  • Sodium fluoride adverse reaction
  • Sodium hyaluronate adverse reaction
  • Surgical tissue adhesive adverse reaction
  • Terpenes adverse reaction
  • Urinary disorder monitoring status
  • Urinary drug side effect
  • Ursodeoxycholic acid adverse reaction
  • Ursodeoxycholic acid adverse reaction
  • Viscosity modifier adverse reaction
  • Xanthine oxidase inhibitor adverse reaction

Table of Drugs and Chemicals

The code T50.995 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. Use as many codes as necessary to describe all reported drugs, medicinal or chemical substances.

Substance Poisoning
Acetohydroxamic acidT50.991T50.992T50.993T50.994T50.995T50.996
Baking sodaT50.991T50.992T50.993T50.994T50.995T50.996
Bromophenol blue reagentT50.991T50.992T50.993T50.994T50.995T50.996
Butylated hydroxy-anisoleT50.991T50.992T50.993T50.994T50.995T50.996
Calculus-dissolving drugT50.991T50.992T50.993T50.994T50.995T50.996
Clodronic acidT50.991T50.992T50.993T50.994T50.995T50.996
Coenzyme AT50.991T50.992T50.993T50.994T50.995T50.996
Colorant [See Also: Dye]T50.991T50.992T50.993T50.994T50.995T50.996
Deanol (aceglumate)T50.991T50.992T50.993T50.994T50.995T50.996
Etidronic acid (disodium salt)T50.991T50.992T50.993T50.994T50.995T50.996
Fat suspension, intravenousT50.991T50.992T50.993T50.994T50.995T50.996
Gallium citrateT50.991T50.992T50.993T50.994T50.995T50.996
Gluconic acidT50.991T50.992T50.993T50.994T50.995T50.996
Guaiac reagentT50.991T50.992T50.993T50.994T50.995T50.996
  »amino acids
  »fat suspension
5-Methoxypsoralen (5-MOP)T50.991T50.992T50.993T50.994T50.995T50.996
8-Methoxypsoralen (8-MOP)T50.991T50.992T50.993T50.994T50.995T50.996
Methylethyl celluloseT50.991T50.992T50.993T50.994T50.995T50.996
Ornithine aspartateT50.991T50.992T50.993T50.994T50.995T50.996
Palm kernel oilT50.991T50.992T50.993T50.994T50.995T50.996
Parathyroid extractT50.991T50.992T50.993T50.994T50.995T50.996
Phenaphthazine reagentT50.991T50.992T50.993T50.994T50.995T50.996
Protein hydrolysateT50.991T50.992T50.993T50.994T50.995T50.996
Psoralens (medicinal)T50.991T50.992T50.993T50.994T50.995T50.996
Teriparatide (acetate)T50.991T50.992T50.993T50.994T50.995T50.996
Thioctic acidT50.991T50.992T50.993T50.994T50.995T50.996
Ursodeoxycholic acidT50.991T50.992T50.993T50.994T50.995T50.996

Information for Patients

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

[Learn More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.