2024 ICD-10-CM Diagnosis Code T46.1X5

Adverse effect of calcium-channel blockers

ICD-10-CM Code:
T46.1X5
ICD-10 Code for:
Adverse effect of calcium-channel blockers
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
        (T46)

T46.1X5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of calcium-channel blockers. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Adverse effect of calcium-channel blockers

Non-specific codes like T46.1X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of calcium-channel blockers:

  • Use T46.1X5A for initial encounter - BILLABLE CODE

  • Use T46.1X5D for subsequent encounter - BILLABLE CODE

  • Use T46.1X5S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Amlodipine adverse reaction
  • Calcium-channel blocker adverse reaction
  • Class IV antiarrhythmic adverse reaction
  • Diltiazem adverse reaction
  • Felodipine adverse reaction
  • Isradipine adverse reaction
  • Lidoflazine adverse reaction
  • Nicardipine adverse reaction
  • Nifedipine adverse reaction
  • Nimodipine adverse reaction
  • Verapamil adverse reaction

Clinical Information

  • Bepridil

    a long-acting calcium-blocking agent with significant anti-anginal activity. the drug produces significant coronary vasodilation and modest peripheral effects. it has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
  • Diltiazem

    a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of calcium ion on membrane functions.
  • Felodipine

    a dihydropyridine calcium antagonist with positive inotropic effects. it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
  • Fendiline

    coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.
  • Gallopamil

    coronary vasodilator that is an analog of iproveratril (verapamil) with one more methoxy group on the benzene ring.
  • Isradipine

    a potent antagonist of calcium channels that is highly selective for vascular smooth muscle. it is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
  • Lidoflazine

    coronary vasodilator with some antiarrhythmic action.
  • Nicardipine

    a potent calcium channel blockader with marked vasodilator action. it has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. it has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
  • Nifedipine

    a potent vasodilator agent with calcium antagonistic action. it is a useful anti-anginal agent that also lowers blood pressure.
  • Nimodipine

    a calcium channel blockader with preferential cerebrovascular activity. it has marked cerebrovascular dilating effects and lowers blood pressure.
  • Nisoldipine

    a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. it is also effective in patients with cardiac failure and angina.
  • Nitrendipine

    a calcium channel blocker with marked vasodilator action. it is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
  • Verapamil

    a calcium channel blocker that is a class iv anti-arrhythmia agent.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
BepridilT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
Blockers, calcium channelT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
DiltiazemT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
FelodipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
FendilineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
GallopamilT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
IproveratrilT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
IsradipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
LidoflazineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
Monoxidine hydrochlorideT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
NicardipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
NifedipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
NimodipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
NisoldipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
NitrendipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
OxodipineT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
TiapamilT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6
VerapamilT46.1X1T46.1X2T46.1X3T46.1X4T46.1X5T46.1X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.