2024 ICD-10-CM Diagnosis Code T42.6X5

Adverse effect of other antiepileptic and sedative-hypnotic drugs

ICD-10-CM Code:
T42.6X5
ICD-10 Code for:
Adverse effect of antiepileptic and sedative-hypnotic drugs
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs
        (T42)

T42.6X5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of other antiepileptic and sedative-hypnotic drugs. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Adverse effect of antiepileptic and sedative-hypnotic drugs

Non-specific codes like T42.6X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of antiepileptic and sedative-hypnotic drugs:

  • Use T42.6X5A for initial encounter - BILLABLE CODE

  • Use T42.6X5D for subsequent encounter - BILLABLE CODE

  • Use T42.6X5S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acne of external chemical origin
  • Acneiform eruption
  • Acneiform eruption due to bromine compound
  • Acneiform eruption due to chemical
  • Adverse reaction caused by bromine and/or bromine compound
  • Adverse reaction caused by bromine and/or bromine compound
  • Adverse reaction caused by bromine and/or bromine compound
  • Adverse reaction to aldehyde
  • Adverse reaction to aldehyde
  • Adverse reaction to aldehyde
  • Adverse reaction to carbromal
  • Adverse reaction to chloral and/or chloral derivative
  • Adverse reaction to glutethimide
  • Adverse reaction to methaqualone
  • Anticonvulsant drug-induced osteomalacia
  • Barbiturate antiepileptic adverse reaction
  • Beclamide adverse reaction
  • Bromine acne
  • Bromoderma
  • Carbamate sedative adverse reaction
  • Chloral hydrate adverse reaction
  • Chlormethiazole adverse reaction
  • Chlormezanone adverse reaction
  • Congenital malformation caused by valproic acid
  • Fetal disorder caused by anticonvulsant via placental transfer
  • Fetal valproate syndrome
  • Gabapentin adverse reaction
  • Halogen acne
  • Halogen eruption
  • Halogen eruption
  • Lamotrigine adverse reaction
  • Metabolic acidosis due to paraldehyde
  • Methyprylone adverse reaction
  • Osteomalacia secondary to drug
  • Paraldehyde adverse reaction
  • Piracetam adverse reaction
  • Primidone adverse reaction
  • Propionic acid derivative adverse reaction
  • Sodium valproate adverse reaction
  • Triclofos sodium adverse reaction
  • Vigabatrin adverse reaction
  • Zolpidem adverse reaction
  • Zopiclone adverse reaction

Clinical Information

  • Bromine

    a halogen with the atomic symbol br, atomic number 35, and atomic weight 79.904. it is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.
  • Bromine Compounds

    inorganic compounds that contain bromine as an integral part of the molecule.
  • Bromine Radioisotopes

    unstable isotopes of bromine that decay or disintegrate emitting radiation. br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.
  • Bromisovalum

    a sedative and mild hypnotic with potentially toxic effects.
  • Chlormethiazole

    a sedative and anticonvulsant often used in the treatment of alcohol withdrawal. chlormethiazole has also been proposed as a neuroprotective agent. the mechanism of its therapeutic activity is not entirely clear, but it does potentiate gamma-aminobutyric acid receptors response and it may also affect glycine receptors.
  • Chlormezanone

    a non-benzodiazepine that is used in the management of anxiety. it has been suggested for use in the treatment of muscle spasm.
  • Ethchlorvynol

    a sedative and hypnotic that has been used in the short-term management of insomnia. its use has been superseded by other drugs.
  • Glutethimide

    a hypnotic and sedative. its use has been largely superseded by other drugs.
  • Paraldehyde

    a hypnotic and sedative with anticonvulsant effects. however, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. it is still occasionally used to control status epilepticus resistant to conventional treatment. (from martindale, the extra pharmacopoeia, 30th ed, p608-9)
  • Primidone

    a barbiturate derivative that acts as a gaba modulator and anti-epileptic agent. it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite.
  • Dipsacales

    an order of dicotyledonous flowering plants which includes six families. it is best known for its ornamental plants such as lonicera (honeysuckle), viburnum (arrowwood and guelder rose), and scabiosa (scabious, or pincushion flower).
  • Valerian

    a plant genus of the family valerianaceae, order dipsacales, subclass asteridae, class magnoliopsida. it is best known for the sedative use and valepotriate content of the roots. it is sometimes called garden heliotrope but is unrelated to true heliotrope (heliotropium).
  • Valerianaceae

    the valerian plant family of the order dipsacales, subclass asteridae, class magnoliopsida that is characterized by 3-5-lobed tubular flowers, often spurred at the base and clustered in tight heads.
  • Valerianella

    a plant genus of the family valerianaceae. it is sometimes called goosefoot cornsalad but should not be confused with true goosefoot (chenopodium).
  • Valproic Acid

    a fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of epilepsy and bipolar disorder. the mechanisms of its therapeutic actions are not well understood. it may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage-gated sodium channels.
  • Vigabatrin

    an analogue of gamma-aminobutyric acid. it is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid and is used as an anticonvulsant. (from martindale the extra pharmacopoeia, 31st ed)
  • Zolpidem

    an imidazopyridine derivative and short-acting gaba-a receptor agonist that is used for the treatment of insomnia.
  • Fetal Valproate Syndrome

    a teratogenic disorder observed in a newborn or child of a mother who was exposed to valproic acid during pregnancy. manifestations include musculoskeletal abnormalities, intellectual disability, spina bifida, and distinctive facial features.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (T42). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AcecarbromalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
AcetylcarbromalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
AcetylpheneturideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
AllylisopropylacetylureaT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
AllyltribromideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ApronalideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
AvomineT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BarbexacloneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BeclamideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Beta-ChlorT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Bromal (hydrate)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Bromide saltsT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromineT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Bromine
  »compounds (medicinal)
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Bromine
  »sedative
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Bromine
  »vapor
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromisovalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromisovalumT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromoformT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromuralT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
BromvaletoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Butylchloral hydrateT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Carbamate (sedative)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Carbamate (sedative)
  »herbicide
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Carbamate (sedative)
  »insecticide
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
CarbromalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChloralT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Chloral
  »derivative
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Chloral
  »hydrate
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChloralamideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChloralodolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChlorbutolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChlorethiazolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChloretoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChlorhexadolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChlormethiazoleT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ChlormezanoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ClomethiazoleT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Cloral betaineT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
DichloralphenozoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Diethylsulfone-diethylmethaneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
DivalproexT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
DoridenT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
DormisonT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
EctylureaT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
EthchlorvynolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
EthinamateT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
EtifoxineT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
GlutethimideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
HexapropymateT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Lactuca (virosa) (extract)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
LactucariumT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Lettuce opiumT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
LevanilT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
LevopromeT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
MeparfynolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Methaqualone (compound)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
MethylparafynolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Methylpentynol, methylpenthynolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
MethyprylonT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
NiaprazineT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
NoctecT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
NoludarT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ParacetaldehydeT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ParaldehydeT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PericlorT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PetrichloralT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PhenacemideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PhenerganT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PheneturideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PhthalimidoglutarimideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PlacidylT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PrimidoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ProgabideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Propionaldehyde (medicinal)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
PyrithyldioneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
QuaaludeT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SedormidT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SerenesilT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SomnosT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SoporT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SulfonalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SulfonethylmethaneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SulfonmethaneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SulthiameT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
SultiameT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TetronalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ToloxatoneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TribromacetaldehydeT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TribromomethaneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TrichloroethanolT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Trichloroethyl phosphateT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TriclofosT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TrionalT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
TripleT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »bromides
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »carbonate
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »vaccine
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »vaccine
    »DPT
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »vaccine
    »including pertussis
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Triple
  »vaccine
    »MMR
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ValerianT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Valerian
  »root
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Valerian
  »tincture
T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ValmidT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ValnoctamideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Valproate (sodium)T42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
Valproic acidT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ValpromideT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
VigabatrinT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
WelldormT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ZolpidemT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6
ZopicloneT42.6X1T42.6X2T42.6X3T42.6X4T42.6X5T42.6X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.