2021 ICD-10-CM Code T46.4X5

Adverse effect of angiotensin-converting-enzyme inhibitors

Version 2021
Replaced Code
Non-Billable Code
Adverse Effect

Not Valid for Submission

T46.4X5 is a "header" nonspecific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of angiotensin-converting-enzyme inhibitors. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

The ICD-10-CM code T46.4X5 might also be used to specify conditions or terms like ace inhibitor-aggravated angioedema, acute drug-induced renal failure, acute renal failure due to ace inhibitor, adverse reaction caused by losartan, angioedema due to angiotensin-converting-enzyme inhibitor , angioedema due to disorder of kinin metabolism, etc.

ICD-10:T46.4X5
Short Description:Adverse effect of angiotensin-converting-enzyme inhibitors
Long Description:Adverse effect of angiotensin-converting-enzyme inhibitors

Code Classification

Specific Coding for Adverse effect of angiotensin-converting-enzyme inhibitors

Header codes like T46.4X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for adverse effect of angiotensin-converting-enzyme inhibitors:

Replaced Code

This code was replaced in the 2021 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2020. This code was replaced for the FY 2021 (October 1, 2020 - September 30, 2021).


  • K59.03 - Drug induced constipation

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

Table of Drugs and Chemicals

The code T46.4X5 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. According to ICD-10 coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
self-harm
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AlaceprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
BenazeprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
CaptoprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
CilazaprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
EnalaprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
EnalaprilatT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
FosinoprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Fosinopril
  »sodium
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
InhibitorT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »angiotensin-converting enzyme
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »carbonic anhydrase
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »fibrinolysis
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »monoamine oxidase NEC
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »monoamine oxidase NEC
    »hydrazine
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »postsynaptic
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
Inhibitor
  »prothrombin synthesis
T46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
LisinoprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
PerindoprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
QuinaprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
RamiprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
SpiraprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6
ZofenoprilT46.4X1T46.4X2T46.4X3T46.4X4T46.4X5T46.4X6

Information for Patients


Drug Reactions

Also called: Side effects

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)