2021 ICD-10-CM Code T45.8X5

Adverse effect of other primarily systemic and hematological agents

Version 2021
Replaced Code
Non-Billable Code
Adverse Effect

Not Valid for Submission

T45.8X5 is a "header" nonspecific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of other primarily systemic and hematological agents. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

The ICD-10-CM code T45.8X5 might also be used to specify conditions or terms like acquired aplastic anemia, acquired red cell aplasia, activated factor vii adverse reaction, adverse reaction caused by coagulation protein, adverse reaction to antiserum constituent , adverse reaction to blood or blood product, etc.

ICD-10:T45.8X5
Short Description:Adverse effect of primarily systemic and hematolog agents
Long Description:Adverse effect of other primarily systemic and hematological agents

Code Classification

Specific Coding for Adverse effect of primarily systemic and hematolog agents

Header codes like T45.8X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for adverse effect of primarily systemic and hematolog agents:

Replaced Code

This code was replaced in the 2021 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2020. This code was replaced for the FY 2021 (October 1, 2020 - September 30, 2021).


  • K59.03 - Drug induced constipation

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

Table of Drugs and Chemicals

The code T45.8X5 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. According to ICD-10 coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
self-harm
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AlbuminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »bovine
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »human serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »human serum
    »salt-poor
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »normal human serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
AminoethylisothiouriumT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Anti-anemic (drug) (preparation)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
AntihemophilicT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »factor
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »fraction
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »globulin concentrate
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »human plasma
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »plasma, dried
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
BALT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »dried
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »drug affecting NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »expander NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »fraction NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »substitute (macromolecular)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
British antilewisiteT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Citrovorum (factor)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
CyanocobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DeferoxamineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DesferrioxamineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Dextran (40) (70) (150)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Dimercaprol (British anti-lewisite)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DimercaptopropanolT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Edathamil disodiumT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Edetate, disodium (calcium)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
EPOT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Epoetin alphaT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
ErythropoietinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Erythropoietin
  »human
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
FactorT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »I (fibrinogen)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »III (thromboplastin)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »VIII (antihemophilic Factor) (concentrate)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »IX complex
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »IX complex
    »human
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Fibrinogen (human)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
FolacinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acid
  »with ferrous salt
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acid
  »antagonist
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folinic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Gelatin (intravenous)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Gelatin (intravenous)
  »absorbable (sponge)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HaptendextranT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Heavy metal antidoteT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HematinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Hematinic preparationT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HEST45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HetastarchT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HumanT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »albumin
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »growth hormone (HGH)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »immune serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HydroxocobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Hydroxyethyl starchT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Leucovorin (factor)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
LiverT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »extract
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »extract
    »for parenteral use
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »fraction 1
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »hydrolysate
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
LMDT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
MecobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
NaturalT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »blood (product)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »gas (piped)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »gas (piped)
    »incomplete combustion
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Normal serum albumin (human), salt-poorT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
OxypolygelatinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Packed red cellsT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PlasmaT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Plasma
  »expander NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Plasma
  »protein fraction (human)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PlasmanateT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolygelineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolyvidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolyvinylpyrrolidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PovidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Povidone
  »iodine
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Pteroylglutamic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PVPT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Red blood cells, packedT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Saccharated iron oxideT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Trace element NECT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
TrientineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Whole blood (human)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6

Information for Patients


Drug Reactions

Also called: Side effects

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)