ICD-10 Code T45.8X5

Adverse effect of other primarily systemic and hematological agents

Version 2019 Replaced Code Non-Billable Code Adverse Effect
ICD-10:T45.8X5
Short Description:Adverse effect of primarily systemic and hematolog agents
Long Description:Adverse effect of other primarily systemic and hematological agents

Not Valid for Submission

ICD-10 T45.8X5 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of other primarily systemic and hematological agents. The code is NOT valid for the year 2019 for the submission of HIPAA-covered transactions.

Consider the following ICD-10 codes with a higher level of specificity:

  • T45.8X5A - Adverse effect of other primarily systemic and hematological agents, initial encounter
  • T45.8X5D - Adverse effect of other primarily systemic and hematological agents, subsequent encounter
  • T45.8X5S - Adverse effect of other primarily systemic and hematological agents, sequela

Deleted Code

This code was deleted in the 2019 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2018. This code was replaced for the FY 2019 (October 1, 2018 - September 30, 2019).

  • K59.03 - Drug induced constipation

Code Classification

  • Injury, poisoning and certain other consequences of external causes (S00–T98)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50)
      • Primarily systemic and hematological agents, NEC (T45)

Information for Medical Professionals

Diagnostic Related Groups

The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC). The diagnosis code T45.8X5 is grouped in the following groups for version MS-DRG V36.0 applicable from 10/01/2018 through 09/30/2019.

  • 922 - OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITH MCC
  • 923 - OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITHOUT MCC
  • 949 - AFTERCARE WITH CC/MCC
  • 950 - AFTERCARE WITHOUT CC/MCC

Synonyms

The following clinical terms are approximate synonyms:

  • Acquired aplastic anemia
  • Acquired red cell aplasia
  • Activated factor VII products adverse reaction
  • Adverse reaction to blood or blood product
  • Adverse reaction to blood plasma
  • Adverse reaction to food additive
  • Adverse reaction to human fibrinogen
  • Adverse reaction to macromolecular blood substitutes
  • Adverse reaction to packed red cells
  • Adverse reaction to whole blood
  • Albumin solution adverse reaction
  • Allergic reaction to chemical
  • Antibody mediated acquired pure red cell aplasia caused by erythropoiesis stimulating agent
  • Antithrombin III adverse reaction
  • Blood clotting factor adverse reaction
  • Blood derivative adverse reaction
  • Cation exchange resin adverse reaction
  • Cyanocobalamin adverse reaction
  • Desferrioxamine adverse reaction
  • Desferrioxamine adverse reaction
  • Desferrioxamine retinopathy
  • Dextran adverse reaction
  • Dextran pseudoallergy
  • Dimercaprol adverse reaction
  • Drug-induced retinopathy
  • Edetate adverse reaction
  • Epoetin alfa adverse reaction
  • Epoetin beta adverse reaction
  • Erythropoietin adverse reaction
  • Factor V concentrate products adverse reaction
  • Factor VII concentrate products adverse reaction
  • Factor VIII by-passing fraction products adverse reaction
  • Factor VIII fraction products adverse reaction
  • Factor XI products adverse reaction
  • Factor XIII products adverse reaction
  • Folic acid adverse reaction
  • Folinic acid adverse reaction
  • Foreign body dermatosis
  • Gelatin adverse reaction
  • Hemostatic adverse reaction
  • Hetastarch adverse reaction
  • Hetastarch pseudoallergy
  • Human protein-induced anaphylaxis
  • Hydroxocobalamin adverse reaction
  • Ion exchange resin adverse reaction
  • Pentastarch adverse reaction
  • Pentastarch pseudoallergy
  • Perfluorochemical adverse reaction
  • Plasma protein solution adverse reaction
  • Plasma substitutes adverse reaction
  • Polyvinyl pyrrolidone disease
  • Sodium calcium edetate adverse reaction
  • Sodium cellulose phosphate adverse reaction
  • Toxic retinopathy
  • Trientine adverse reaction
  • Vitamin B12 preparation adverse reaction
  • Vitamin B12 preparation adverse reaction
  • Von Willebrand factor products adverse reaction

Table of Drugs and Chemicals

The code T45.8X5 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. Use as many codes as necessary to describe all reported drugs, medicinal or chemical substances.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
self-harm
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AlbuminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »bovine
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »human serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »human serum
    »salt-poor
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Albumin
  »normal human serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
AminoethylisothiouriumT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Anti-anemic (drug) (preparation)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
AntihemophilicT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »factor
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »fraction
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »globulin concentrate
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »human plasma
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Antihemophilic
  »plasma, dried
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
BALT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »dried
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »drug affecting NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »expander NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »fraction NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Blood (derivatives) (natural) (plasma) (whole)
  »substitute (macromolecular)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
British antilewisiteT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Citrovorum (factor)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
CyanocobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DeferoxamineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DesferrioxamineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Dextran (40) (70) (150)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Dimercaprol (British anti-lewisite)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
DimercaptopropanolT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Edathamil disodiumT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Edetate, disodium (calcium)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
EPOT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Epoetin alphaT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
ErythropoietinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Erythropoietin
  »human
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
FactorT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »I (fibrinogen)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »III (thromboplastin)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »VIII (antihemophilic Factor) (concentrate)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »IX complex
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Factor
  »IX complex
    »human
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Fibrinogen (human)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
FolacinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acid
  »with ferrous salt
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folic acid
  »antagonist
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Folinic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Gelatin (intravenous)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Gelatin (intravenous)
  »absorbable (sponge)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HaptendextranT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Heavy metal antidoteT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HematinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Hematinic preparationT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HEST45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HetastarchT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HumanT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »albumin
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »growth hormone (HGH)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Human
  »immune serum
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
HydroxocobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Hydroxyethyl starchT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Leucovorin (factor)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
LiverT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »extract
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »extract
    »for parenteral use
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »fraction 1
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Liver
  »hydrolysate
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
LMDT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
MecobalaminT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
NaturalT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »blood (product)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »gas (piped)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Natural
  »gas (piped)
    »incomplete combustion
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Normal serum albumin (human), salt-poorT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
OxypolygelatinT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Packed red cellsT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PlasmaT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Plasma
  »expander NEC
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Plasma
  »protein fraction (human)
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PlasmanateT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolygelineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolyvidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PolyvinylpyrrolidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PovidoneT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Povidone
  »iodine
T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Pteroylglutamic acidT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
PVPT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Red blood cells, packedT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Saccharated iron oxideT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Trace element NECT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
TrientineT45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6
Whole blood (human)T45.8X1T45.8X2T45.8X3T45.8X4T45.8X5T45.8X6

Information for Patients


Drug Reactions

Also called: Side effects

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

  • Angioedema (Medical Encyclopedia)
  • Drug allergies (Medical Encyclopedia)
  • Drug-induced diarrhea (Medical Encyclopedia)
  • Drug-induced tremor (Medical Encyclopedia)
  • Taking multiple medicines safely (Medical Encyclopedia)

[Read More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.