2026 ICD-10-CM Diagnosis Code Z15.01Genetic susceptibility to malignant neoplasm of breast

ICD-10-CM Codes›Z00–Z99›Z14-Z15›Z15

ICD-10-CM Z15.01
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z15.01 is a billable ICD-10-CM diagnosis code for genetic susceptibility to malignant neoplasm of breast. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as BRCA1 gene mutation detected. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genetic susceptibility to disease.

Code Identity

ICD-10-CM Code
Z15.01
Billable Status
Yes — Valid for Submission
Code Describes
Genetic susceptibility to malignant neoplasm of breast
Short Description
Genetic susceptibility to malignant neoplasm of breast
Same as the full description in the CMS dataset.
Parent Code
Z15.0
Genetic susceptibility to malignant neoplasm

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ14-Z15Genetic carrier and genetic susceptibility to disease
CategoryZ15Genetic susceptibility to disease
This CodeZ15.01Genetic susceptibility to malignant neoplasm of breast

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z15.01.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z15.01 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • BRCA1 gene mutation detected
  • BRCA2 gene mutation detected
  • Breast cancer genetic marker of susceptibility detected
  • Genetic susceptibility to cancer
  • Li-Fraumeni syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Family, familial
      • Li-Fraumeni (syndrome)
    • Genetic
      • susceptibility to disease NEC
        • malignant neoplasm
          • breast
    • Susceptibility to disease, genetic
      • malignant neoplasm
        • breast
    • Syndrome
      • Li-Fraumeni

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC029
Genetic susceptibility to disease
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Breast cancer

Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer).

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z15.01 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V84.01 Genetc sus mal neo brest
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z15.01Overview

Is Z15.01 (Genetic susceptibility to malignant neoplasm) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic susceptibility to malignant neoplasm of breast on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z15.01 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because genetic susceptibility to malignant neoplasm of breast describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z15.01 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for genetic susceptibility to malignant neoplasm of breast on inpatient claims.

What is the ICD-9 equivalent of Z15.01?

Under the General Equivalence Mappings, genetic susceptibility to malignant neoplasm of breast converts to ICD-9-CM V84.01 (genetc sus mal neo brest). The mapping is a direct match.