2026 ICD-10-CM Diagnosis Code T80.69XSOther serum reaction due to other serum, sequela
T80.69XS is a billable ICD-10-CM diagnosis code for other serum reaction due to other serum, sequela. The 7th character S marks it as a sequela code, which reports a problem that remains after the original condition has resolved. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 922 through 923. The code is exempt from POA reporting. Coders also document this condition as immune complex urticaria. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication, sequela.
Code Identity
Code Classification
Present on Admission (POA)Billing
T80.69XS is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Immune complex urticaria
- Serum sickness caused by drug
- Serum sickness type vasculitis
- Urticaria caused by serum
- Urticaria medicamentosa
- Urticarial transfusion reaction
Coding GuidelinesGuidance
The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Convert T80.69XS to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T80.69XSOverview
Is T80.69XS (Other serum reaction due to other serum) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other serum reaction due to other serum, sequela on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What does the 7th character S in T80.69XS mean?
The final character S makes this a sequela code: it reports a lingering problem that remains after the other serum reaction due to other serum itself has resolved, not the original event.
What MS-DRG does T80.69XS group to?
When other serum reaction due to other serum, sequela is the principal diagnosis on an inpatient stay, it groups to MS-DRG 922, 923, with relative weights from 1.0177 to 1.7494 depending on complications. Higher weights mean higher Medicare reimbursement.
Is T80.69XS exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for other serum reaction due to other serum, sequela on inpatient claims.
What is the ICD-9 equivalent of T80.69XS?
Under the General Equivalence Mappings, other serum reaction due to other serum, sequela converts to ICD-9-CM 909.3 (late eff surg/med compl). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
