2027 ICD-10-CM Diagnosis Code T80Complications following infusion, transfusion and therapeutic injection

ICD-10-CM Codes›S00–T88›T80-T88›T80

ICD-10-CM T80
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

T80 is a non-billable ICD-10-CM category code for complications following infusion, transfusion and therapeutic injection, so it cannot be submitted on claims. Use a more specific code from this category instead, such as T80.0XXA, T80.0XXD, T80.0XXS, and T80.1XXA.

Code Identity

ICD-10-CM Code
T80
Billable Status
No — Non-Billable Category
Code Describes
Complications following infusion, transfusion and therapeutic injection
Short Description
Comp following infusion, transfusion and theraputc injection
Chapter
T80-T88
Complications of surgical and medical care, not elsewhere classified

Code Classification

ChapterS00–T88Injury, poisoning and certain other consequences of external causes
SectionT80-T88Complications of surgical and medical care, not elsewhere classified
CategoryT80Complications following infusion, transfusion and therapeutic injection
This CodeT80Complications following infusion, transfusion and therapeutic injection

Specific Coding for Comp following infusion, transfusion and theraputc injectionOverview

Non-specific codes like T80 require more characters. Use one of these billable codes instead:

  • T80.0 for Air embolism following infusion, transfusion and therapeutic injection

  • T80.1 for Vascular complications following infusion, transfusion and therapeutic injection

  • T80.2 for Infections following infusion, transfusion and therapeutic injection

  • T80.21 for Infection due to central venous catheter

  • T80.22 for Acute infection following transfusion, infusion, or injection of blood and blood products

  • T80.29 for Infection following other infusion, transfusion and therapeutic injection

  • T80.3 for ABO incompatibility reaction due to transfusion of blood or blood products

  • T80.30 for ABO incompatibility reaction due to transfusion of blood or blood products, unspecified

  • T80.31 for ABO incompatibility with hemolytic transfusion reaction

  • T80.39 for Other ABO incompatibility reaction due to transfusion of blood or blood products

  • T80.4 for Rh incompatibility reaction due to transfusion of blood or blood products

  • T80.40 for Rh incompatibility reaction due to transfusion of blood or blood products, unspecified

  • T80.41 for Rh incompatibility with hemolytic transfusion reaction

  • T80.49 for Other Rh incompatibility reaction due to transfusion of blood or blood products

  • T80.5 for Anaphylactic reaction due to serum

  • T80.51 for Anaphylactic reaction due to administration of blood and blood products

  • T80.52 for Anaphylactic reaction due to vaccination

  • T80.59 for Anaphylactic reaction due to other serum

  • T80.6 for Other serum reactions

  • T80.61 for Other serum reaction due to administration of blood and blood products

  • T80.62 for Other serum reaction due to vaccination

  • T80.69 for Other serum reaction due to other serum

  • T80.8 for Other complications following infusion, transfusion and therapeutic injection

  • T80.81 for Extravasation of vesicant agent

  • T80.82 for Complication of immune effector cellular therapy

  • T80.89 for Other complications following infusion, transfusion and therapeutic injection

  • T80.9 for Unspecified complication following infusion, transfusion and therapeutic injection

  • T80.90 for Unspecified complication following infusion and therapeutic injection

  • T80.91 for Hemolytic transfusion reaction, unspecified incompatibility

  • T80.92 for Unspecified transfusion reaction

  • T80.A for Non-ABO incompatibility reaction due to transfusion of blood or blood products

  • T80.A0 for Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecified

  • T80.A1 for Non-ABO incompatibility with hemolytic transfusion reaction

  • T80.A9 for Other non-ABO incompatibility reaction due to transfusion of blood or blood products

Coding GuidelinesGuidance

The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the applicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to T80: its own notes plus those printed at block T80-T88 and Chapter 19. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

  • complications following perfusion

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

On T80 itself
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)
From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator [ventilator] (J95.850)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block T80-T88 Complications of surgical and medical care, not elsewhere classified applies to 1,683 codes
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • code(s) to identify the specified condition resulting from the complication
  • code to identify devices involved and details of circumstances (Y62-Y82)
From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • code to identify any retained foreign body, if applicable (Z18.-)

Notes

General instructions on how these codes are used.

From Chapter 19 (S00-T88) Injury, poisoning and certain other consequences of external causes applies to 41,187 codes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

7th Character

Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.

  • The appropriate 7th character is to be added to each code from category T80
Values for category T80 Encounter: Initial, Subsequent, Sequela
  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name T80, its category, or a range that includes it.

Excludes2 3

These codes carry an Excludes2 note naming T80: its condition is not part of those codes, and both may be reported when the patient has both.

  • T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
    transfusion reactions (T80.-)
  • T81 Complications of procedures, not elsewhere classified
    complications following infusion, transfusion and therapeutic injection (T80.-)
  • T88 Other complications of surgical and medical care, not elsewhere classified
    complication following infusion, transfusion and therapeutic injection (T80.-)

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About T80Overview

Is T80 a billable code?

No. This is a category header that groups the codes for complications following infusion, transfusion and therapeutic injection, and headers cannot be submitted on claims. Claims for complications following infusion, transfusion and therapeutic injection need a more specific code from this category, such as T80.0XXA, T80.0XXD, and T80.0XXS.