2027 ICD-10-CM Diagnosis Code T46.5X1APoisoning by other antihypertensive drugs, accidental (unintentional), initial encounter
T46.5X1A is a billable ICD-10-CM diagnosis code for poisoning by other antihypertensive drugs, accidental (unintentional), initial encounter. The 7th character A marks it as an initial encounter code, used while the patient is receiving active treatment. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 917 through 918. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under External cause codes: intent of injury, accidental/unintentional; External cause codes: poisoning by drug; and Poisoning by drugs, initial encounter.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Accidental antihypertensive overdose
- Accidental clonidine overdose
- Accidental clonidine poisoning
- Accidental diazoxide overdose
- Accidental diazoxide poisoning
- Accidental guanethidine overdose
- Accidental guanethidine poisoning
- Accidental hydralazine overdose
- Accidental hydralazine poisoning
- Accidental poisoning by adrenergics
- Adrenergic neurone blocking drug overdose
- Adrenergic neurone blocking drug poisoning
- Alpha-adrenoceptor agonist overdose
- Antihypertensive overdose
- Central alpha-2 adrenergic receptor agonist overdose
- Central alpha-2 adrenergic receptor agonist poisoning
- Clonidine overdose
- Diazoxide overdose
- Guanethidine overdose
- Hydralazine overdose
- Hydralazine poisoning
- Poisoning by clonidine
- Poisoning by diazoxide
- Poisoning by guanethidine
- Poisoning by rauwolfia alkaloid
- Reserpine poisoning
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to T46.5X1A: its own notes plus those printed at T46.5, T46, block T36-T50, and Chapter 19. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- poisoning by, adverse effect of and underdosing of metaraminol (T44.4)
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify any retained foreign body, if applicable (Z18.-)
Notes
General instructions on how these codes are used.
- Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
- The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
7th Character
Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.
- The appropriate 7th character is to be added to each code from category T46
- Ainitial encounter this code
- Dsubsequent encounter
- Ssequela
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name T46.5X1A, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming T46.5X1A: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 2
These codes carry an Excludes2 note naming T46.5X1A: its condition is not part of those codes, and both may be reported when the patient has both.
- T44.8 Poisoning by, adverse effect of and underdosing of centrally-acting and adrenergic-neuron- blocking agentspoisoning by, adverse effect of and underdosing of clonidine (T46.5) names T46.5, which includes this code
- T44.8 Poisoning by, adverse effect of and underdosing of centrally-acting and adrenergic-neuron- blocking agentspoisoning by, adverse effect of and underdosing of guanethidine (T46.5) names T46.5, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of Drugs and ChemicalsClinical
Substances in the Table of Drugs and Chemicals that reference this code family. Always confirm in the Tabular List before coding.
Patient EducationClinical
Medication Errors
Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert T46.5X1A to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About T46.5X1AOverview
Is T46.5X1A a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report poisoning by other antihypertensive drugs, accidental (unintentional), initial encounter on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What does the 7th character A in T46.5X1A mean?
The final character A marks the initial encounter: use it while the patient is receiving active treatment for poisoning by other antihypertensive drugs, accidental (unintentional), such as an emergency visit or first evaluation.
What MS-DRG does T46.5X1A group to?
When poisoning by other antihypertensive drugs, accidental (unintentional), initial encounter is the principal diagnosis on an inpatient stay, it groups to MS-DRG 918, 917, with relative weights from 0.8716 to 1.5698 depending on complications. Higher weights mean higher Medicare reimbursement.
Can T46.5X1A be reported with T44.4?
Not as a rule. The Excludes1 note at T46, which applies to T46.5X1A, lists "poisoning by, adverse effect of and underdosing of metaraminol (T44.4)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of T46.5X1A?
Under the General Equivalence Mappings, poisoning by other antihypertensive drugs, accidental (unintentional), initial encounter converts to ICD-9-CM 972.6 (pois-antihyperten agent) and E858.3 (acc poisn-cardiovasc agt). The mapping is approximate, so confirm the match fits the documentation.
