2027 ICD-10-CM Diagnosis Code T46Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
T46 is a non-billable ICD-10-CM category code for poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system, so it cannot be submitted on claims. Use a more specific code from this category instead, such as T46.0X1A, T46.0X1D, T46.0X1S, and T46.0X2A.
Code Identity
Code Classification
Specific Coding for Agents primarily affecting the cardiovascular systemOverview
Non-specific codes like T46 require more characters. Use one of these billable codes instead:
T46.0 for Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
T46.0X for Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
T46.1 for Poisoning by, adverse effect of and underdosing of calcium-channel blockers
T46.1X for Poisoning by, adverse effect of and underdosing of calcium-channel blockers
T46.2 for Poisoning by, adverse effect of and underdosing of other antidysrhythmic drugs, not elsewhere classified
T46.2X for Poisoning by, adverse effect of and underdosing of other antidysrhythmic drugs
T46.3 for Poisoning by, adverse effect of and underdosing of coronary vasodilators
T46.3X for Poisoning by, adverse effect of and underdosing of coronary vasodilators
T46.4 for Poisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors
T46.4X for Poisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors
T46.5 for Poisoning by, adverse effect of and underdosing of other antihypertensive drugs
T46.5X for Poisoning by, adverse effect of and underdosing of other antihypertensive drugs
T46.6 for Poisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs
T46.6X for Poisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs
T46.7 for Poisoning by, adverse effect of and underdosing of peripheral vasodilators
T46.7X for Poisoning by, adverse effect of and underdosing of peripheral vasodilators
T46.8 for Poisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents
T46.8X for Poisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents
T46.9 for Poisoning by, adverse effect of and underdosing of other and unspecified agents primarily affecting the cardiovascular system
T46.90 for Poisoning by, adverse effect of and underdosing of unspecified agents primarily affecting the cardiovascular system
T46.99 for Poisoning by, adverse effect of and underdosing of other agents primarily affecting the cardiovascular system
Coding GuidelinesGuidance
When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined). If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the applicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027, published by CMS and the National Center for Health Statistics.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to T46: its own notes plus those printed at block T36-T50 and Chapter 19. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- poisoning by, adverse effect of and underdosing of metaraminol (T44.4)
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify any retained foreign body, if applicable (Z18.-)
Notes
General instructions on how these codes are used.
- Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
- The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
7th Character
Every code in the category takes a 7th character from the listed values, with the placeholder X filling any empty positions before it.
- The appropriate 7th character is to be added to each code from category T46
- Ainitial encounter
- Dsubsequent encounter
- Ssequela
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code HistoryHistory
Questions About T46Overview
Is T46 a billable code?
No. This is a category header that groups the codes for poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system, and headers cannot be submitted on claims. Claims for poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system need a more specific code from this category, such as T46.0X1A, T46.0X1D, and T46.0X1S.
Can T46 be reported with T44.4?
Not as a rule. The Excludes1 note on T46 lists "poisoning by, adverse effect of and underdosing of metaraminol (T44.4)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
