2026 ICD-10-CM Diagnosis Code Q81.8Other epidermolysis bullosa

ICD-10-CM Codes›Q00-Q99›Q80-Q89›Q81

ICD-10-CM Q81.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Q81.8 is a billable ICD-10-CM diagnosis code for other epidermolysis bullosa. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 595 through 596. The code is exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified congenital anomalies.

Code Identity

ICD-10-CM Code
Q81.8
Billable Status
Yes — Valid for Submission
Code Describes
Other epidermolysis bullosa
Short Description
Other epidermolysis bullosa
Same as the full description in the CMS dataset.
Parent Code
Q81
Epidermolysis bullosa

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ80-Q89Other congenital malformations
CategoryQ81Epidermolysis bullosa
This CodeQ81.8Other epidermolysis bullosa

Present on Admission (POA)Billing

Q81.8 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal granulation tissue
  • Aplasia cutis congenita in association with epidermolysis bullosa
  • Autosomal dominant epidermolysis bullosa simplex
  • Cicatricial junctional epidermolysis bullosa
  • Congenital junctional epidermolysis bullosa
  • Congenital junctional epidermolysis bullosa-pyloric atresia syndrome
  • Epidermolysis bullosa pruriginosa
  • Gastric atresia
  • Generalized dystrophic epidermolysis bullosa
  • Generalized junctional epidermolysis bullosa
  • Granulation of skin
  • Inverse junctional epidermolysis bullosa
  • Junctional epidermolysis bullosa
  • Junctional epidermolysis bullosa mitis
  • Junctional epidermolysis bullosa non-Herlitz type
  • Laryngo-onycho-cutaneous syndrome
  • Late-onset junctional epidermolysis bullosa
  • Late-onset localized junctional epidermolysis bullosa, intellectual disability syndrome
  • Localized junctional epidermolysis bullosa
  • Localized non-Herlitz junctional epidermolysis bullosa
  • Progressive junctional epidermolysis bullosa
  • Pyloric atresia
  • Weber-Cockayne syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Epidermolysis
      • bullosa (congenital)
        • specified NEC
    • Goldscheider's disease
    • Köebner's syndrome
    • Weber-Cockayne syndrome(epidermolysis bullosa)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MAL010
Other specified and unspecified congenital anomalies
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Epidermolysis Bullosa

    group of genetically determined disorders characterized by the blistering of skin and mucosae. there are four major forms: acquired, simple, junctional, and dystrophic. each of the latter three has several varieties.

  • Epidermolysis Bullosa Acquisita

    form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. direct immunofluorescence shows immunoglobulin g deposited at the dermo-epidermal junction.

  • Epidermolysis Bullosa Dystrophica

    form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. it is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. all forms of dystrophic epidermolysis bullosa result from mutations in collagen type vii, a major component fibrils of basement membrane and epidermis.

  • Epidermolysis Bullosa Simplex

    a form of epidermolysis bullosa characterized by serous bullae that heal without scarring. mutations in the genes that encode keratin-5 and keratin-14 have been associated with several subtypes of epidermolysis bullosa simplex.

  • Epidermolysis Bullosa, Junctional

    form of epidermolysis bullosa having onset at birth or during the neonatal period and transmitted through autosomal recessive inheritance. it is characterized by generalized blister formation, extensive denudation, and separation and cleavage of the basal cell plasma membranes from the basement membrane.

  • Severe Junctional Epidermolysis Bullosa 3B|Generalized Severe Epidermolysis Bullosa|JEB-H|JEB3B|Junctional Epidermolysis Bullosa Type Herlitz

    an autosomal recessive condition caused by mutation(s) in the lamc2 gene, encoding laminin subunit gamma-2. it is characterized by severe skin blisters and erosions and is often fatal.

  • Junctional Epidermolysis Bullosa

    epidermolysis bullosa characterized by separation of the skin through the lamina lucida resulting in blister formation. it includes lethal and non-lethal variants.

  • LAMC2 wt Allele|B2T|BM600|CSF|EBR2|EBR2A|LAMB2T|LAMNB2|Lam5, Gamma-2 Subunit Gene|Laminin 5, Gamma-2 Subunit Gene|Laminin, Gamma 2 (Nicein (100kD), Kalinin (105kD), BM600 (100kD), Herlitz Junctional Epidermolysis Bullosa)) Gene|Laminin, Gamma 2 wt Allele|Laminin, Gamma-2 Gene|Laminin, Nicein, Beta-2 Gene

    human lamc2 wild-type allele is located within 1q25-q31 and is approximately 59 kb in length. this allele, which encodes laminin subunit gamma-2 protein, is involved in both the development of the epidermis and extracellular matrix organization. mutation of the gene is associated with herlitz junctional epidermolysis bullosa.

Patient EducationClinical

Skin Conditions

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Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Q81.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
757.39 Skin anomaly NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Q81.8Overview

Is Q81.8 (Epidermolysis bullosa) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other epidermolysis bullosa on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does Q81.8 group to?

When other epidermolysis bullosa is the principal diagnosis on an inpatient stay, it groups to MS-DRG 595, 596, with relative weights from 1.0825 to 2.1207 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q81.8 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for other epidermolysis bullosa on inpatient claims.

What is the ICD-9 equivalent of Q81.8?

Under the General Equivalence Mappings, other epidermolysis bullosa converts to ICD-9-CM 757.39 (skin anomaly NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.