2027 ICD-10-CM Diagnosis Code P59.3Neonatal jaundice from breast milk inhibitor

ICD-10-CM Codes›P00–P96›P50-P61›P59

ICD-10-CM P59.3
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

P59.3 is a billable ICD-10-CM diagnosis code for neonatal jaundice from breast milk inhibitor. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 795. Coders also document this condition as neonatal jaundice due to delayed conjugation. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic jaundice and perinatal jaundice.

Code Identity

ICD-10-CM Code
P59.3
Billable Status
Yes — Valid for Submission
Code Describes
Neonatal jaundice from breast milk inhibitor
Short Description
Neonatal jaundice from breast milk inhibitor
Same as the full description in the CMS dataset.
Parent Code
P59
Neonatal jaundice from other and unspecified causes

Code Classification

ChapterP00–P96Certain conditions originating in the perinatal period
SectionP50-P61Hemorrhagic and hematological disorders of newborn
CategoryP59Neonatal jaundice from other and unspecified causes
This CodeP59.3Neonatal jaundice from breast milk inhibitor

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Neonatal jaundice due to delayed conjugation
  • Neonatal jaundice due to delayed conjugation from breast milk inhibitor

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to P59.3: its own notes plus those printed at P59, block P50-P61, and Chapter 16. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • conditions that have their origin in the fetal or perinatal period (before birth through the first 28 days after birth) even if morbidity occurs later

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From P59 Neonatal jaundice from other and unspecified causes applies to 7 codes
  • jaundice due to inborn errors of metabolism (E70-E88)
  • kernicterus (P57.-)
From Block P50-P61 Hemorrhagic and hematological disorders of newborn applies to 67 codes
  • congenital stenosis and stricture of bile ducts (Q44.3)
  • Crigler-Najjar syndrome (E80.5)
  • Dubin-Johnson syndrome (E80.6)
  • Gilbert syndrome (E80.4)
  • hereditary hemolytic anemias (D55-D58)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • tetanus neonatorum (A33)

Notes

General instructions on how these codes are used.

From Chapter 16 (P00-P96) Certain conditions originating in the perinatal period applies to 463 codes
  • Codes from this chapter are for use on newborn records only, never on maternal records

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name P59.3, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming P59.3: they are not reported together with it, unless the two conditions are unrelated.

  • K72 Hepatic failure, not elsewhere classified
    icterus of newborn (P55-P59) names P55-P59, which includes this code
  • R17 Unspecified jaundice
    neonatal jaundice (P55, P57-P59) names P57-P59, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming P59.3: its condition is not part of those codes, and both may be reported when the patient has both.

  • Block R70-R79 Abnormal findings on examination of blood, without diagnosis
    hemorrhagic and hematological disorders of newborn (P50-P61) names P50-P61, which includes this code

Code Also 1

These codes say P59.3 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • K76.82 Hepatic encephalopathy
    icterus of newborn (P55-P59) names P55-P59, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR PNL007
Hemolytic jaundice and perinatal jaundice
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Jaundice

Jaundice causes your skin and the whites of your eyes to turn yellow. Too much bilirubin causes jaundice. Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert P59.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
774.39 Delay conjugat jaund NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About P59.3Overview

What is the ICD-10 code for neonatal jaundice from breast milk inhibitor?

The ICD-10-CM code for neonatal jaundice from breast milk inhibitor is P59.3 (sometimes written as P593). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is P59.3 (Neonatal jaundice from other and unspecified causes) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neonatal jaundice from breast milk inhibitor on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does P59.3 group to?

When neonatal jaundice from breast milk inhibitor is the principal diagnosis on an inpatient stay, it groups to MS-DRG 795 (normal Newborn), which carries a relative weight of 0.2022. Higher weights mean higher Medicare reimbursement.

Can P59.3 be reported with a code from P57?

Not as a rule. The Excludes1 note at P59, which applies to P59.3, lists "kernicterus (P57.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of P59.3?

Under the General Equivalence Mappings, neonatal jaundice from breast milk inhibitor converts to ICD-9-CM 774.39 (delay conjugat jaund NEC). The mapping is approximate, so confirm the match fits the documentation.