2026 ICD-10-CM Diagnosis Code P59.1Inspissated bile syndrome

ICD-10-CM Codes›P00–P96›P50-P61›P59

ICD-10-CM P59.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

P59.1 is a billable ICD-10-CM diagnosis code for inspissated bile syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as extrahepatic obstructive biliary disease. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic jaundice and perinatal jaundice.

Code Identity

ICD-10-CM Code
P59.1
Billable Status
Yes — Valid for Submission
Code Describes
Inspissated bile syndrome
Short Description
Inspissated bile syndrome
Same as the full description in the CMS dataset.
Parent Code
P59
Neonatal jaundice from other and unspecified causes

Code Classification

ChapterP00–P96Certain conditions originating in the perinatal period
SectionP50-P61Hemorrhagic and hematological disorders of newborn
CategoryP59Neonatal jaundice from other and unspecified causes
This CodeP59.1Inspissated bile syndrome

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Extrahepatic obstructive biliary disease
  • Inspissated bile syndrome
  • Neonatal jaundice due to inspissated bile syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Inspissated bile syndrome(newborn)
    • Jaundice(yellow)
      • newborn
        • due to or associated with
          • inspissated bile syndrome
    • Syndrome
      • inspissated bile (newborn)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR PNL007
Hemolytic jaundice and perinatal jaundice
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Inspissated Bile Syndrome

    a syndrome characterized by persistent jaundice, hemolytic anemia, and hepatomegaly in a newborn. it is characterized by the presence of inspissated bile plugs in the bile ducts.

  • Perinatal Jaundice Related to Inspissated Bile Syndrome|Perinatal Jaundice due to Inspissated Bile Syndrome|Perinatal Jaundice due to Inspissated Bile Syndrome

    yellow pigmentation of the skin, mucous membranes and eyes due to hyperbilirubinemia caused by inspissated bile plugs in the bile ducts during the perinatal period.

Patient EducationClinical

Jaundice

Jaundice causes your skin and the whites of your eyes to turn yellow. Too much bilirubin causes jaundice. Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert P59.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
774.4 Fetal/neonatal hepatitis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About P59.1Overview

Is P59.1 (Neonatal jaundice from other and unspecified causes) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report inspissated bile syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of P59.1?

Under the General Equivalence Mappings, inspissated bile syndrome converts to ICD-9-CM 774.4 (fetal/neonatal hepatitis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.