2026 ICD-10-CM Diagnosis Code P59.1Inspissated bile syndrome
ICD-10-CM Codes›P00–P96›P50-P61›P59
- Billable — Valid for Submission
- MCC — Major Complication or Comorbidity
- Not Chronic
P59.1 is a billable ICD-10-CM diagnosis code for inspissated bile syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 791, 793. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 35 closely related codes. Coders also document this condition as extrahepatic obstructive biliary disease. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic jaundice and perinatal jaundice.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Extrahepatic obstructive biliary disease
- Inspissated bile syndrome
- Neonatal jaundice due to inspissated bile syndrome
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Syndrome See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Inspissated Bile Syndrome
a syndrome characterized by persistent jaundice, hemolytic anemia, and hepatomegaly in a newborn. it is characterized by the presence of inspissated bile plugs in the bile ducts.Perinatal Jaundice Related to Inspissated Bile Syndrome|Perinatal Jaundice due to Inspissated Bile Syndrome|Perinatal Jaundice due to Inspissated Bile Syndrome
yellow pigmentation of the skin, mucous membranes and eyes due to hyperbilirubinemia caused by inspissated bile plugs in the bile ducts during the perinatal period.
Patient EducationClinical
Jaundice
Jaundice causes your skin and the whites of your eyes to turn yellow. Too much bilirubin causes jaundice. Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver.
Read the full article at MedlinePlus
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Convert P59.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About P59.1Overview
What is the ICD-10 code for inspissated bile syndrome?
The ICD-10-CM code for inspissated bile syndrome is P59.1 (sometimes written as P591). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is P59.1 (Neonatal jaundice from other and unspecified causes) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report inspissated bile syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does P59.1 group to?
When inspissated bile syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 791, 793, with relative weights from 4.0590 to 4.1696 depending on complications. Higher weights mean higher Medicare reimbursement.
Is P59.1 a CC or MCC?
CMS lists P59.1 as an MCC (major complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 35 closely related codes in its exclusion list.
What is the ICD-9 equivalent of P59.1?
Under the General Equivalence Mappings, inspissated bile syndrome converts to ICD-9-CM 774.4 (fetal/neonatal hepatitis). The mapping is approximate, so confirm the match fits the documentation.
