2027 ICD-10-CM Diagnosis Code N07.BHereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD]

ICD-10-CM Codes›N00–N99›N00-N08›N07

ICD-10-CM N07.B
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

N07.B is a billable ICD-10-CM diagnosis code for hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD]. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 698 through 700. Coders also document this condition as apolipoprotein L1 mediated kidney disease. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nephritis; nephrosis; renal sclerosis.

N07.B does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the ESRD (V21) category 141 for payment year 2027.

Code Identity

ICD-10-CM Code
N07.B
Billable Status
Yes — Valid for Submission
Code Describes
Hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD]
Short Description
Hereditary nephrop, NEC with APOL1-mediated kidney disease
Parent Code
N07
Hereditary nephropathy, not elsewhere classified

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN00-N08Glomerular diseases
CategoryN07Hereditary nephropathy, not elsewhere classified
This CodeN07.BHereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD]

Medicare Risk Adjustment (HCC)Billing

N07.B does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Other CMS Models
ESRD (V21): HCC 141
ESRD V21 weights: 0.000 dialysis, 0.000 functioning graft
Part D (RxHCC)
Not mapped
N07.B does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Apolipoprotein L1 mediated kidney disease

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to N07.B: its own notes plus those printed at N07, block N00-N08, and Chapter 14. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • AMKD (with glomerulonephritis)
  • AMKD (with glomerulosclerosis)

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block N00-N08 Glomerular diseases applies to 107 codes
  • hypertensive chronic kidney disease (I12.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From N07 Hereditary nephropathy, not elsewhere classified applies to 12 codes
  • Alport's syndrome (Q87.81-)
  • hereditary amyloid nephropathy (E85.-)
  • nail patella syndrome (Q87.2)
  • non-neuropathic heredofamilial amyloidosis (E85.-)
From Chapter 14 (N00-N99) Diseases of the genitourinary system applies to 838 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From Block N00-N08 Glomerular diseases applies to 107 codes
  • any associated kidney failure (N17-N19).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN001
Nephritis; nephrosis; renal sclerosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement N07.B replaces the following previously assigned code(s):

  • N07.8 - Hereditary nephropathy, NEC w oth morphologic lesions
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About N07.BOverview

Is N07.B (Hereditary nephropathy, not elsewhere classified) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD] on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does N07.B group to?

When hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 699, 698, 700, with relative weights from 0.6740 to 1.6400 depending on complications. Higher weights mean higher Medicare reimbursement.

Can N07.B be reported with a code from I12?

Not as a rule. The Excludes1 note at block N00-N08, which applies to N07.B, lists "hypertensive chronic kidney disease (I12.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does N07.B risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: N07.B maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the ESRD (V21) category 141 (Nephritis).