Unspecified nephritic syndrome (N05) ICD-10-CM
The N05 code range covers unspecified nephritic syndrome with 12 ICD-10-CM diagnosis codes. 11 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- glomerular disease NOS
- glomerulonephritis NOS
- nephritis NOS
- nephropathy NOS and renal disease NOS with morphological lesion specified in .0-.8
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the N05 Range 12 codes · 11 billable
- N05 Unspecified nephritic syndromeNon-billable
- N05.0 Unspecified nephritic syndrome with minor glomerular abnormality
- N05.1 Unspecified nephritic syndrome with focal and segmental glomerular lesions
- N05.2 Unspecified nephritic syndrome with diffuse membranous glomerulonephritis
- N05.3 Unspecified nephritic syndrome with diffuse mesangial proliferative glomerulonephritis
- N05.4 Unspecified nephritic syndrome with diffuse endocapillary proliferative glomerulonephritis
- N05.5 Unspecified nephritic syndrome with diffuse mesangiocapillary glomerulonephritis
- N05.6 Unspecified nephritic syndrome with dense deposit disease
- N05.7 Unspecified nephritic syndrome with diffuse crescentic glomerulonephritis
- N05.8 Unspecified nephritic syndrome with other morphologic changes
- N05.9 Unspecified nephritic syndrome with unspecified morphologic changes
- N05.A Unspecified nephritic syndrome with C3 glomerulonephritis
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the N05 range.
Astroviridae
A family of RNA viruses with two genera: MAMASTROVIRUS and AVASTROVIRUS. They cause GASTROENTERITIS in humans and also infect other vertebrates.
Avastrovirus
A genus of ASTROVIRIDAE infecting avian species and often involving extra-intestinal manifestations. The type species is Turkey astrovirus.
Glomerulonephritis
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Glomerulonephritis, IGA
A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.
Glomerulonephritis, Membranoproliferative
Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Glomerulonephritis, Membranous
A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Glomerulosclerosis, Focal Segmental
A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Heymann Nephritis Antigenic Complex
A complex of antigenic proteins obtained from the brush border of kidney tubules. It contains two principal components LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2 and LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN. The name of this complex is derived from researcher, Dr. Walter Heymann, who developed an experimental model of membranous glomerulonephritis (GLOMERULONEPHRITIS) by injecting this antigenic complex into rats to induce an autoimmune response.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Low Density Lipoprotein Receptor-Related Protein-2
An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.
Lupus Nephritis
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Nephritis
Inflammation of any part of the KIDNEY.
Nephritis, Hereditary
A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.
Nephritis, Interstitial
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Nephrosis, Lipoid
A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
About the N05 Code Range
ICD-10 code N05 covers unspecified nephritic syndrome, a group of kidney disorders characterized by inflammation and damage to the glomeruli, which filter blood in the kidneys. These codes specify different types of nephritic syndrome, identified by their unique patterns of glomerular injury.
This section includes codes like N05.0 for minimal change disease, also known as steroid-sensitive or steroid-resistant minimal change glomerulonephritis, and N05.1 for lesions such as focal segmental glomerulosclerosis. Other detailed codes include N05.2 for membranous glomerulonephritis in various stages, and N05.7 for crescentic glomerulonephritis, which often appears as severe inflammation. The classification also covers conditions like dense deposit disease (N05.6) and C3 glomerulonephritis (N05.A). Using these specific ICD-10 codes for nephritic syndrome helps medical coders accurately document and communicate the precise nature of kidney inflammation, guiding treatment and tracking outcomes.
Questions About This Page
How many billable codes are in the N05 range?
Of the 12 codes in this range, 11 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the N05 range classify?
The range classifies unspecified nephritic syndrome. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
