Unspecified nephritic syndrome (N05)

    • ICD-10 Index

      • Diseases of the genitourinary system (N00–N99)

        • Glomerular diseases (N00-N08)

            • Unspecified nephritic syndrome (N05)
            • N05 - Unspecified nephritic syndrome NON-BILLABLE CODE
            • N05.0 - Unsp nephritic syndrome with minor glomerular abnormality BILLABLE CODE
            • N05.1 - Unsp neph syndrome w focal and segmental glomerular lesions BILLABLE CODE
            • N05.2 - Unsp nephritic syndrome w diffuse membranous glomrlneph BILLABLE CODE
            • N05.3 - Unsp neph syndrome w diffuse mesangial prolif glomrlneph BILLABLE CODE
            • N05.4 - Unsp neph syndrome w diffuse endocaplry prolif glomrlneph BILLABLE CODE
            • N05.5 - Unsp nephritic syndrome w diffuse mesangiocap glomrlneph BILLABLE CODE
            • N05.6 - Unspecified nephritic syndrome with dense deposit disease BILLABLE CODE
            • N05.7 - Unsp nephritic syndrome w diffuse crescentic glomrlneph BILLABLE CODE
            • N05.8 - Unsp nephritic syndrome with other morphologic changes BILLABLE CODE
            • N05.9 - Unsp nephritic syndrome with unspecified morphologic changes BILLABLE CODE
            • N05.A - Unspecified nephritic syndrome with C3 glomerulonephritis BILLABLE CODE

Clinical Information for Unspecified nephritic syndrome (N05)

Glomerulonephritis - Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.

Glomerulonephritis, IGA - A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.

Glomerulonephritis, Membranoproliferative - Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.

Glomerulonephritis, Membranous - A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.

Glomerulosclerosis, Focal Segmental - A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.

Lupus Nephritis - Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

Nephrosis, Lipoid - A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.

Avastrovirus - A genus of ASTROVIRIDAE infecting avian species and often involving extra-intestinal manifestations. The type species is Turkey astrovirus.

Heymann Nephritis Antigenic Complex - A complex of antigenic proteins obtained from the brush border of kidney tubules. It contains two principal components LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2 and LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN. The name of this complex is derived from researcher, Dr. Walter Heymann, who developed an experimental model of membranous glomerulonephritis (GLOMERULONEPHRITIS) by injecting this antigenic complex into rats to induce an autoimmune response.

Low Density Lipoprotein Receptor-Related Protein-2 - An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.

Nephritis - Inflammation of any part of the KIDNEY.

Nephritis, Hereditary - A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.

Nephritis, Interstitial - Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.

Astroviridae - A family of RNA viruses with two genera: MAMASTROVIRUS and AVASTROVIRUS. They cause GASTROENTERITIS in humans and also infect other vertebrates.

Kidney - Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Instructional Notations

Includes Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.

  • glomerular disease NOS
  • glomerulonephritis NOS
  • nephritis NOS
  • nephropathy NOS and renal disease NOS with morphological lesion specified in .0-.8

Type 1 Excludes Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • nephropathy NOS with no stated morphological lesion N28.9
  • renal disease NOS with no stated morphological lesion N28.9
  • tubulo-interstitial nephritis NOS N12