2026 ICD-10-CM Diagnosis Code N04.22Secondary membranous nephropathy with nephrotic syndrome

ICD-10-CM Codes›N00–N99›N00-N08›N04

ICD-10-CM N04.22
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

N04.22 is a billable ICD-10-CM diagnosis code for secondary membranous nephropathy with nephrotic syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 698 through 700. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nephritis; nephrosis; renal sclerosis.

Code Identity

ICD-10-CM Code
N04.22
Billable Status
Yes — Valid for Submission
Code Describes
Secondary membranous nephropathy with nephrotic syndrome
Short Description
Secondary membranous nephropathy with nephrotic syndrome
Same as the full description in the CMS dataset.
Parent Code
N04.2
Nephrotic syndrome with diffuse membranous glomerulonephritis

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN00-N08Glomerular diseases
CategoryN04Nephrotic syndrome
This CodeN04.22Secondary membranous nephropathy with nephrotic syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Code First

  • , if applicable, other disease or disorder or poisoning causing membranous nephropathy

Use Additional Code

  • code, if applicable, for adverse effect of drug causing membranous nephropathy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Nephropathy
      • membranous (diffuse)
        • with
          • nephrotic syndrome
            • secondary
    • Nephropathy
      • membranous (diffuse)
        • secondary
          • with nephrotic syndrome

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN001
Nephritis; nephrosis; renal sclerosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement N04.22 replaces the following previously assigned code(s):

  • N04.2 - Nephrotic syndrome w diffuse membranous glomerulonephritis
FY 2024AddedAdded to the ICD-10-CM code setEffective October 1, 2023.
FY 2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About N04.22Overview

Is N04.22 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report secondary membranous nephropathy with nephrotic syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does N04.22 group to?

When secondary membranous nephropathy with nephrotic syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 698, 699, 700, with relative weights from 0.6899 to 1.6544 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.