2027 ICD-10-CM Diagnosis Code L10.5Drug-induced pemphigus
ICD-10-CM Codes›L00–L99›L10-L14›L10
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
L10.5 is a billable ICD-10-CM diagnosis code for drug-induced pemphigus. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 595 through 596. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 21 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified inflammatory condition of skin.
L10.5 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 314 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
L10.5 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Drug-induced pemphigus
- Drug-induced pemphigus foliaceus
- Drug-induced pemphigus vulgaris
- Pemphigus foliaceus
- Pemphigus vulgaris
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to L10.5: its own notes plus those printed at L10, block L10-L14, and Chapter 12. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- lipomelanotic reticulosis (I89.8)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- systemic connective tissue disorders (M30-M36)
- viral warts (B07.-)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
drug-induced L10.5
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Pemphigus
group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert L10.5 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About L10.5Overview
What is the ICD-10 code for drug-induced pemphigus?
The ICD-10-CM code for drug-induced pemphigus is L10.5 (sometimes written as L105). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is L10.5 (Pemphigus) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced pemphigus on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does L10.5 group to?
When drug-induced pemphigus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 596, 595, with relative weights from 1.1067 to 2.0230 depending on complications. Higher weights mean higher Medicare reimbursement.
Is L10.5 a CC or MCC?
CMS lists L10.5 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 21 closely related codes in its exclusion list.
Can L10.5 be reported with L01.03?
Not as a rule. The Excludes1 note at L10, which applies to L10.5, lists "pemphigus neonatorum (L01.03)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does L10.5 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage: L10.5 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 314 (Pemphigus, Pemphigoid, and Other Bullous Skin Disorders).
