2027 ICD-10-CM Diagnosis Code G93.41Metabolic encephalopathy

ICD-10-CM Codes›G00–G99›G89-G99›G93

ICD-10-CM G93.41
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

G93.41 is a billable ICD-10-CM diagnosis code for metabolic encephalopathy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 70 through 72, 974 through 976. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 10 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other nervous system disorders (neither hereditary nor degenerative).

Code Identity

ICD-10-CM Code
G93.41
Billable Status
Yes — Valid for Submission
Code Describes
Metabolic encephalopathy
Short Description
Metabolic encephalopathy
Same as the full description in the CMS dataset.
Parent Code
G93.4
Other and unspecified encephalopathy

Code Classification

ChapterG00–G99Diseases of the nervous system
SectionG89-G99Other disorders of the nervous system
CategoryG93Other disorders of brain
This CodeG93.41Metabolic encephalopathy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 3-Methylglutaconic aciduria type 4
  • Acute disorder of hemodialysis
  • Acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate
  • Atypical glycine encephalopathy
  • Childhood encephalopathy due to thiamine pyrophosphokinase deficiency
  • Complication of hemodialysis
  • Congenital microcephaly, severe encephalopathy, progressive cerebral atrophy syndrome
  • Deficiency of dioxygenase
  • Dialysis disequilibrium syndrome
  • Encephalopathy due to mitochondrial and peroxisomal fission defect
  • Encephalopathy due to sulfite oxidase deficiency
  • Encephalopathy with sepsis
  • Ethylmalonic encephalopathy
  • Ethylmalonic encephalopathy protein 1 deficiency
  • Glucose transporter protein type 1 deficiency syndrome
  • Hyperglycinemia
  • Hyponatremic encephalopathy
  • Inborn error of amino acid metabolism
  • Infantile glycine encephalopathy
  • ITPA-related lethal infantile neurological disorder with cataract and cardiac involvement
  • MEGDEL syndrome
  • Metabolic encephalopathy
  • Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency
  • Mitochondrial encephalomyopathy
  • Mitochondrial neurogastrointestinal encephalomyopathy syndrome
  • Myxedema encephalopathy
  • Non-ketotic hyperglycinemia
  • Progressive polyneuropathy with bilateral striatal necrosis
  • Recurrent encephalopathy
  • Recurrent metabolic encephalomyopathic crises, rhabdomyolysis, cardiac arrhythmia, intellectual disability syndrome
  • Secondary amyloid encephalopathy
  • Severe X-linked mitochondrial encephalomyopathy
  • SLC25A42 gene-related mitochondrial encephalomyopathy
  • Thiamine-responsive encephalopathy
  • TMEM70 related mitochondrial encephalo-cardio-myopathy
  • Urate encephalopathy
  • Uremic encephalopathy

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to G93.41: its own notes plus those printed at G93.4 and Chapter 6. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Septic encephalopathy

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From G93.4 Other and unspecified encephalopathy applies to 7 codes
  • alcoholic encephalopathy (G31.2)
  • encephalopathy in diseases classified elsewhere (G94)
  • hypertensive encephalopathy (I67.4)
  • toxic (metabolic) encephalopathy (G92.8)
From Chapter 6 (G00-G99) Diseases of the nervous system applies to 700 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name G93.41, its category, or a range that includes it.

Use Additional Code 3

These codes say to use an additional code from the note, and G93.41 is one of the codes named.

  • M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
    encephalopathy (metabolic) (septic) (G93.41)
  • R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
    encephalopathy (metabolic) (septic) (G93.41)
  • R65.2 Severe sepsis
    encephalopathy (metabolic) (septic) (G93.41)

Code Also 1

These codes say G93.41 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • F78.A1 SYNGAP1-related intellectual disability
    encephalopathy (G93.4-) names G93.4-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS020
Other nervous system disorders (neither hereditary nor degenerative)
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Brain Diseases, Metabolic

    acquired or inborn metabolic diseases that produce brain dysfunction or damage. these include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.

Patient EducationClinical

Brain Diseases

Your brain is the control center of your body. It controls your thoughts, memory, speech, and movement. It regulates the function of many organs. It's part of your nervous system, which also includes your spinal cord and peripheral nerves. The nervous system sends signals between your brain and the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert G93.41 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
348.31 Metabolic encephalopathy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About G93.41Overview

What is the ICD-10 code for metabolic encephalopathy?

The ICD-10-CM code for metabolic encephalopathy is G93.41 (sometimes written as G9341). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is G93.41 (Other and unspecified encephalopathy) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report metabolic encephalopathy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does G93.41 group to?

When metabolic encephalopathy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 974, 976, 72, 975, 70, 71, with relative weights from 0.7344 to 3.0488 depending on complications. Higher weights mean higher Medicare reimbursement.

Is G93.41 a CC or MCC?

CMS lists G93.41 as an MCC (major complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 10 closely related codes in its exclusion list.

What is the ICD-9 equivalent of G93.41?

Under the General Equivalence Mappings, metabolic encephalopathy converts to ICD-9-CM 348.31 (metabolic encephalopathy). The mapping is a direct match.