Toxic encephalopathy (G92) ICD-10-CM
The G92 code range covers toxic encephalopathy with 10 ICD-10-CM diagnosis codes. 8 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the G92 Range 10 codes · 8 billable
- G92 Toxic encephalopathyNon-billable
- G92.0 Immune effector cell-associated neurotoxicity syndromeNon-billable
- G92.00 Immune effector cell-associated neurotoxicity syndrome, grade unspecified
- G92.01 Immune effector cell-associated neurotoxicity syndrome, grade 1
- G92.02 Immune effector cell-associated neurotoxicity syndrome, grade 2
- G92.03 Immune effector cell-associated neurotoxicity syndrome, grade 3
- G92.04 Immune effector cell-associated neurotoxicity syndrome, grade 4
- G92.05 Immune effector cell-associated neurotoxicity syndrome, grade 5
- G92.8 Other toxic encephalopathy
- G92.9 Unspecified toxic encephalopathy
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the G92 range.
Immune Effector Cell Associated Neurotoxicity Syndrome
Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.
Immune Effector Cell Associated Neurotoxicity Syndrome Grade 1
Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.
Immune Effector Cell Associated Neurotoxicity Syndrome Grade 2
Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 3, 4, 5, or 6 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken to voice commands.
Immune Effector Cell Associated Neurotoxicity Syndrome Grade 3
Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of greater than or equal to 9 (for children 12 and under), the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.
Immune Effector Cell Associated Neurotoxicity Syndrome Grade 4
Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE scale cannot be performed (for adults and children over 12), or if the Cornell Assessment of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under), the inability of the affected individual to be arousable without vigorous or repetitive tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or repetitive clinical or electroencephalographically-detected seizures without ever returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema or Cushing's triad (bradycardia, hypertension, respiratory depression).
Immune Effector Cell Associated Neurotoxicity Syndrome Grade 5
Death due to Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) where another cause is not the primary determinant.
About the G92 Code Range
Toxic encephalopathy describes brain dysfunction linked to toxicity. This category also includes nervous system toxicity associated with immune effector cells.
G92.0 identifies immune effector cell-associated neurotoxicity syndrome and divides it by grade, from an unspecified grade through grade 5. G92.8 identifies other toxic encephalopathy, while G92.9 identifies unspecified toxic encephalopathy.
Questions About This Page
How many billable codes are in the G92 range?
Of the 10 codes in this range, 8 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the G92 range classify?
The range classifies toxic encephalopathy. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
