2026 ICD-10-CM Diagnosis Code G35.DMultiple sclerosis, unspecified

ICD-10-CM Codes›G00–G99›G35-G37›G35

ICD-10-CM G35.D
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

G35.D is a billable ICD-10-CM diagnosis code for multiple sclerosis, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026).

Code Identity

ICD-10-CM Code
G35.D
Billable Status
Yes — Valid for Submission
Code Describes
Multiple sclerosis, unspecified
Short Description
Multiple sclerosis, unspecified
Same as the full description in the CMS dataset.
Parent Code
G35
Multiple sclerosis

Code Classification

ChapterG00–G99Diseases of the nervous system
SectionG35-G37Demyelinating diseases of the central nervous system
CategoryG35Multiple sclerosis
This CodeG35.DMultiple sclerosis, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute relapsing multiple sclerosis
  • Autonomic disorder due to multiple sclerosis
  • Autonomic nervous system disorder co-occurrent and due to neurodegenerative disorder
  • Benign multiple sclerosis
  • Brown-Séquard syndrome due to multiple sclerosis
  • Central neuropathic pain
  • Chorea due to immunological disorder
  • Chronic central neuropathic pain
  • Chronic central neuropathic pain due to multiple sclerosis
  • Cognitive impairment due to multiple sclerosis
  • Dementia associated with multiple sclerosis
  • Dementia due to multiple sclerosis with altered behavior
  • Demyelination of spinal cord
  • Exacerbation of multiple sclerosis
  • Functional quadriplegia due to multiple sclerosis
  • Hemichorea
  • Hemichorea due to multiple sclerosis
  • Intermediate uveitis
  • Lamellar ichthyosis
  • Malignant multiple sclerosis
  • Marburg acute multiple sclerosis
  • Multiple sclerosis
  • Multiple sclerosis associated intermediate uveitis
  • Multiple sclerosis of the brainstem
  • Multiple sclerosis of the spinal cord
  • Multiple sclerosis, ichthyosis, factor VIII deficiency syndrome
  • Myelitis due to multiple sclerosis
  • Optic neuritis due to demyelinating disease
  • Pediatric multiple sclerosis
  • Posterior cord syndrome due to multiple sclerosis
  • Progressive multiple sclerosis
  • Progressive relapsing multiple sclerosis
  • Retrobulbar neuritis
  • Retrobulbar neuritis due to multiple sclerosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Disseminated multiple sclerosis
  • Generalized multiple sclerosis
  • Multiple sclerosis NOS
  • Multiple sclerosis of brain stem
  • Multiple sclerosis of cord

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dementia(degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety)
      • in (due to)
        • multiple
          • sclerosis
    • Dementia(degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety)
      • in (due to)
        • multiple
          • sclerosis
            • with behavioral disturbance
    • Demyelination, demyelinization
      • global
    • Disease, diseased
      • demyelinating, demyelinizating (nervous system)
        • multiple sclerosis
    • Myelosclerosis
      • disseminated, of nervous system
    • Sclérose en plaques
    • Sclerosis, sclerotic
      • ascending multiple
    • Sclerosis, sclerotic
      • brain (generalized) (lobular)
        • disseminated
    • Sclerosis, sclerotic
      • brain (generalized) (lobular)
        • insular
    • Sclerosis, sclerotic
      • brain (generalized) (lobular)
        • miliary
    • Sclerosis, sclerotic
      • brain (generalized) (lobular)
        • multiple
    • Sclerosis, sclerotic
      • brain (generalized) (lobular)
        • stem, multiple
    • Sclerosis, sclerotic
      • bulbar, multiple
    • Sclerosis, sclerotic
      • cerebrospinal (disseminated) (multiple)
    • Sclerosis, sclerotic
      • combined (spinal cord)
        • multiple
    • Sclerosis, sclerotic
      • disseminated
    • Sclerosis, sclerotic
      • dorsal
    • Sclerosis, sclerotic
      • insular
    • Sclerosis, sclerotic
      • multiple (brain stem) (cerebral) (disseminated) (generalized) (spinal cord)
    • Sclerosis, sclerotic
      • plaques
    • Sclerosis, sclerotic
      • spinal (cord) (progressive)
        • combined
          • multiple
    • Sclerosis, sclerotic
      • spinal (cord) (progressive)
        • disseminated
    • Sclerosis, sclerotic
      • spinal (cord) (progressive)
        • multiple

Clinical InformationClinical

  • Multiple Sclerosis

    an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. the usual pattern is one of recurrent attacks followed by partial recovery (see multiple sclerosis, relapsing-remitting), but acute fulminating and chronic progressive forms (see multiple sclerosis, chronic progressive) also occur. (adams et al., principles of neurology, 6th ed, p903)

  • Multiple Sclerosis, Chronic Progressive

    a form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. if the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. when the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. the term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (from ann neurol 1994;36 suppl:s73-s79; adams et al., principles of neurology, 6th ed, pp903-914)

  • Multiple Sclerosis, Relapsing-Remitting

    the most common clinical variant of multiple sclerosis, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. common clinical manifestations include loss of visual (see optic neuritis), motor, sensory, or bladder function. acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (adams et al., principles of neurology, 6th ed, pp903-914)

  • ABCA12 wt Allele|ABC12|ARCI4A|ARCI4B|ATP Binding Cassette Subfamily A Member 12 wt Allele|ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 Gene|ATP-Binding Cassette, Subfamily A, Member 12 Gene|DKFZP434G232|ICR2B|Ichthyosis Congenita II, Lamellar Ichthyosis B Gene|LI2

    human abca12 wild-type allele is located in the vicinity of 2q35 and is approximately 207 kb in length. this allele, which encodes glucosylceramide transporter abca12 protein, plays a role in both the membrane localization of glucosylceramide and other lipids in lamellar granules and in cholesterol transport. mutation of the gene is associated with autosomal recessive congenital ichthyosis (arci) types 4a and 4b (harlequin).

  • Lamellar Ichthyosis

    a very rare, autosomal recessive inherited skin disorder present at birth. it is characterized by the presence of a transparent membrane encasing the newborn. this membrane sheds in about two weeks after birth to reveal generalized scaling and skin erythema.

Code History & ChangesHistory

New Code G35.D was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.

Replacement G35.D replaces the following previously assigned code(s):

  • G35 - Multiple sclerosis
FY 2026AddedAdded to the ICD-10-CM code setEffective October 1, 2025.
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About G35.DOverview

Is G35.D (Multiple sclerosis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report multiple sclerosis, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.