2026 ICD-10-CM Diagnosis Code G35Multiple sclerosis

ICD-10-CM Codes›G00–G99›G35-G37›G35

ICD-10-CM G35
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

G35 is a non-billable ICD-10-CM category code for multiple sclerosis, so it cannot be submitted on claims. Use a more specific code from this category instead, such as G35.A, G35.B0, G35.B1, and G35.B2. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Multiple sclerosis.

For Medicare Advantage risk adjustment, G35 maps to CMS-HCC Category 198 (Multiple Sclerosis) under the V28 model, adding a risk factor of about 0.647 for a community, non-dual, aged beneficiary in payment year 2026.

Code Identity

ICD-10-CM Code
G35
Billable Status
No — Non-Billable Category
Code Describes
Multiple sclerosis
Short Description
Multiple sclerosis
Same as the full description in the CMS dataset.
Chapter
G35-G37
Demyelinating diseases of the central nervous system

Code Classification

ChapterG00–G99Diseases of the nervous system
SectionG35-G37Demyelinating diseases of the central nervous system
CategoryG35Multiple sclerosis
This CodeG35Multiple sclerosis

Specific Coding for Multiple sclerosisOverview

Non-specific codes like G35 require more characters. Use one of these billable codes instead:

  • Use G35.A for Relapsing-remitting multiple sclerosis

  • G35.B for Primary progressive multiple sclerosis

  • Use G35.B0 for Primary progressive multiple sclerosis, unspecified

  • Use G35.B1 for Active primary progressive multiple sclerosis

  • Use G35.B2 for Non-active primary progressive multiple sclerosis

  • G35.C for Secondary progressive multiple sclerosis

  • Use G35.C0 for Secondary progressive multiple sclerosis, unspecified

  • Use G35.C1 for Active secondary progressive multiple sclerosis

  • Use G35.C2 for Non-active secondary progressive multiple sclerosis

  • Use G35.D for Multiple sclerosis, unspecified

Medicare Risk Adjustment (HCC)Billing

G35 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.

CMS-HCC V28 Category (Payment Model)
HCC 198— Multiple Sclerosis
Payment HCC · PY 2026 one of 20 ICD-10-CM codes in this category
Risk Adjustment Factor (RAF) Weight
+0.647
community, non-dual, aged · ranges 0.226–1.143 across segments
Hierarchy
Top of its hierarchy
HCC 198 is not superseded by any other condition category
Prior Model (CMS-HCC V24)
HCC 77
V24 retired V28 pays 100% of MA risk scores since PY 2026
Other CMS Models
PACE (CMS-HCC V22): HCC 77 · ESRD (V21): HCC 77 · ESRD (V24): HCC 77
ESRD V21 weights: 0.069 dialysis, 0.000–0.546 functioning graft · ESRD V24 weights: 0.111 dialysis, 0.042–1.113 functioning graft
Part D (RxHCC)
RxHCC 159 — Multiple Sclerosis
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS005
Multiple sclerosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Multiple Sclerosis

    an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. the usual pattern is one of recurrent attacks followed by partial recovery (see multiple sclerosis, relapsing-remitting), but acute fulminating and chronic progressive forms (see multiple sclerosis, chronic progressive) also occur. (adams et al., principles of neurology, 6th ed, p903)

  • Multiple Sclerosis, Chronic Progressive

    a form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. if the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. when the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. the term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (from ann neurol 1994;36 suppl:s73-s79; adams et al., principles of neurology, 6th ed, pp903-914)

  • Multiple Sclerosis, Relapsing-Remitting

    the most common clinical variant of multiple sclerosis, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. common clinical manifestations include loss of visual (see optic neuritis), motor, sensory, or bladder function. acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (adams et al., principles of neurology, 6th ed, pp903-914)

  • ABCA12 wt Allele|ABC12|ARCI4A|ARCI4B|ATP Binding Cassette Subfamily A Member 12 wt Allele|ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 Gene|ATP-Binding Cassette, Subfamily A, Member 12 Gene|DKFZP434G232|ICR2B|Ichthyosis Congenita II, Lamellar Ichthyosis B Gene|LI2

    human abca12 wild-type allele is located in the vicinity of 2q35 and is approximately 207 kb in length. this allele, which encodes glucosylceramide transporter abca12 protein, plays a role in both the membrane localization of glucosylceramide and other lipids in lamellar granules and in cholesterol transport. mutation of the gene is associated with autosomal recessive congenital ichthyosis (arci) types 4a and 4b (harlequin).

  • Lamellar Ichthyosis

    a very rare, autosomal recessive inherited skin disorder present at birth. it is characterized by the presence of a transparent membrane encasing the newborn. this membrane sheds in about two weeks after birth to reveal generalized scaling and skin erythema.

Patient EducationClinical

Multiple Sclerosis

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert G35 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
340 Multiple sclerosis
Exact Match The mapping is direct, with no qualifiers.

Code History & ChangesHistory

Replaced This code was replaced in the FY 2026 code set by:

  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.A - Relapsing-remitting multiple sclerosis
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B0 - Primary progressive multiple sclerosis, unspecified
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B1 - Active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.B2 - Non-active primary progressive multiple sclerosis
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C0 - Secondary progressive multiple sclerosis, unspecified
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C1 - Active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.C2 - Non-active secondary progressive multiple sclerosis
  • G35.D - Multiple sclerosis, unspecified
  • G35.D - Multiple sclerosis, unspecified
  • G35.D - Multiple sclerosis, unspecified
  • G35.D - Multiple sclerosis, unspecified
  • G35.D - Multiple sclerosis, unspecified
  • G35.D - Multiple sclerosis, unspecified
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentRevised in the current code setEffective October 1, 2025 through September 30, 2026.

Questions About G35Overview

What is the ICD-10 code for multiple sclerosis?

G35 is the ICD-10-CM category for multiple sclerosis, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is G35 (Multiple sclerosis) a billable code?

No. This is a category header that groups the codes for multiple sclerosis, and headers cannot be submitted on claims. Claims for multiple sclerosis need a more specific code from this category, such as G35.A, G35.B0, and G35.B1.

What is the ICD-9 equivalent of G35?

Under the General Equivalence Mappings, multiple sclerosis converts to ICD-9-CM 340 (multiple sclerosis). The mapping is a direct match.

What HCC is G35?

G35 (multiple sclerosis) maps to CMS-HCC Category 198 (Multiple Sclerosis), commonly written as HCC 198, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 77 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 159.

Does G35 risk-adjust for Medicare Advantage payment?

Yes. When documented and reported on a Medicare Advantage encounter, G35 adds a risk adjustment factor of about 0.647 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.226 to 1.143 depending on the payment segment). HCC 198 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 198 category page.