ICD-10-CM Code G35

Multiple sclerosis

Version 2021 Billable Code

Valid for Submission

G35 is a billable code used to specify a medical diagnosis of multiple sclerosis. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code G35 might also be used to specify conditions or terms like acute relapsing multiple sclerosis, altered behavior, benign multiple sclerosis, brainstem encephalitis, cognitive impairment due to multiple sclerosis, dementia associated with multiple sclerosis, etc

Short Description:Multiple sclerosis
Long Description:Multiple sclerosis

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code G35:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Disseminated multiple sclerosis
  • Generalized multiple sclerosis
  • Multiple sclerosis NOS
  • Multiple sclerosis of brain stem
  • Multiple sclerosis of cord

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code G35 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acute relapsing multiple sclerosis
  • Altered behavior
  • Benign multiple sclerosis
  • Brainstem encephalitis
  • Cognitive impairment due to multiple sclerosis
  • Dementia associated with multiple sclerosis
  • Dementia due to multiple sclerosis with altered behavior
  • Demyelination of spinal cord
  • Exacerbation of multiple sclerosis
  • Functional quadriplegia due to multiple sclerosis
  • Lamellar ichthyosis
  • Malignant multiple sclerosis
  • Marburg acute multiple sclerosis
  • Multiple sclerosis
  • Multiple sclerosis of the brainstem
  • Multiple sclerosis of the spinal cord
  • Multiple sclerosis, ichthyosis, factor VIII deficiency syndrome
  • Primary progressive multiple sclerosis
  • Progressive multiple sclerosis
  • Progressive relapsing multiple sclerosis
  • Relapsing remitting multiple sclerosis
  • Secondary progressive multiple sclerosis

Clinical Information

  • MULTIPLE SCLEROSIS-. an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. clinical manifestations include visual loss extra ocular movement disorders paresthesias loss of sensation weakness dysarthria spasticity ataxia and bladder dysfunction. the usual pattern is one of recurrent attacks followed by partial recovery see multiple sclerosis relapsing remitting but acute fulminating and chronic progressive forms see multiple sclerosis chronic progressive also occur. adams et al. principles of neurology 6th ed p903
  • MULTIPLE SCLEROSIS CHRONIC PROGRESSIVE-. a form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. if the clinical course is free of distinct remissions it is referred to as primary progressive multiple sclerosis. when the progressive decline is punctuated by acute exacerbations it is referred to as progressive relapsing multiple sclerosis. the term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. from ann neurol 1994;36 suppl:s73 s79; adams et al. principles of neurology 6th ed pp903 914
  • MULTIPLE SCLEROSIS RELAPSING REMITTING-. the most common clinical variant of multiple sclerosis characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. common clinical manifestations include loss of visual see optic neuritis motor sensory or bladder function. acute episodes of demyelination may occur at any site in the central nervous system and commonly involve the optic nerves spinal cord brain stem and cerebellum. adams et al. principles of neurology 6th ed pp903 914

Convert G35 to ICD-9

  • 340 - Multiple sclerosis

Code Classification

  • Diseases of the nervous system (G00–G99)
    • Demyelinating diseases of the central nervous system (G35-G37)
      • Multiple sclerosis (G35)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Multiple Sclerosis

Also called: MS

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include

  • Visual disturbances
  • Muscle weakness
  • Trouble with coordination and balance
  • Sensations such as numbness, prickling, or "pins and needles"
  • Thinking and memory problems

No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak, or walk.

There is no single test for MS. Doctors use a medical history, physical exam, neurological exam, MRI, and other tests to diagnose it. There is no cure for MS, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help.

NIH: National Institute of Neurological Disorders and Stroke

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[Learn More]

Multiple sclerosis Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.Multiple sclerosis usually begins in early adulthood, between ages 20 and 40. The symptoms vary widely, and affected individuals can experience one or more effects of nervous system damage. Multiple sclerosis often causes sensory disturbances in the limbs, including a prickling or tingling sensation (paresthesia), numbness, pain, and itching. Some people experience Lhermitte sign, which is an electrical shock-like sensation that runs down the back and into the limbs. This sensation usually occurs when the head is bent forward. Problems with muscle control are common in people with multiple sclerosis. Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty walking, or poor bladder control. Multiple sclerosis is also associated with vision problems, such as blurred or double vision or partial or complete vision loss. Infections that cause fever can make the symptoms worse.There are several forms of multiple sclerosis: relapsing-remitting MS, secondary progressive MS, primary progressive MS, and progressive relapsing MS. The most common is the relapsing-remitting form, which affects approximately 80 percent of people with multiple sclerosis. Individuals with this form of the condition have periods during which they experience symptoms, called clinical attacks, followed by periods without any symptoms (remission). The triggers of clinical attacks and remissions are unknown. After about 10 years, relapsing-remitting MS usually develops into another form of the disorder called secondary progressive MS. In this form, there are no remissions, and symptoms of the condition continually worsen.Primary progressive MS is the next most common form, affecting approximately 10 to 20 percent of people with multiple sclerosis. This form is characterized by constant symptoms that worsen over time, with no clinical attacks or remissions. Primary progressive MS typically begins later than the other forms, around age 40.Progressive relapsing MS is a rare form of multiple sclerosis that initially appears like primary progressive MS, with constant symptoms. However, people with progressive relapsing MS also experience clinical attacks of more severe symptoms.
[Learn More]