2027 ICD-10-CM Diagnosis Code E03.2Hypothyroidism due to medicaments and other exogenous substances

ICD-10-CM Codes›E00–E89›E00-E07›E03

ICD-10-CM E03.2
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E03.2 is a billable ICD-10-CM diagnosis code for hypothyroidism due to medicaments and other exogenous substances. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. Coders also document this condition as acquired central hypothyroidism. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Thyroid disorders.

E03.2 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 44 for payment year 2027.

Code Identity

ICD-10-CM Code
E03.2
Billable Status
Yes — Valid for Submission
Code Describes
Hypothyroidism due to medicaments and other exogenous substances
Short Description
Hypothyroidism due to meds and oth exogenous substances
Parent Code
E03
Other hypothyroidism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE00-E07Disorders of thyroid gland
CategoryE03Other hypothyroidism
This CodeE03.2Hypothyroidism due to medicaments and other exogenous substances

Medicare Risk Adjustment (HCC)Billing

E03.2 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Part D (RxHCC)
RxHCC 44 — Thyroid Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired central hypothyroidism
  • Central hypothyroidism
  • Drug induced acquired central hypothyroidism
  • Hypothyroidism caused by amiodarone
  • Hypothyroidism caused by drug
  • Hypothyroidism caused by iodide excess
  • Hypothyroidism caused by resorcinol
  • Hypothyroidism resulting from para-aminosalicylic acid
  • Hypothyroidism resulting from phenylbutazone
  • Iatrogenic hypothyroidism

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E03.2: its own notes plus those printed at E03 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E03 Other hypothyroidism applies to 8 codes
  • iodine-deficiency related hypothyroidism (E00-E02)
  • postprocedural hypothyroidism (E89.0)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Code First

The underlying condition named in the note is sequenced before this code.

  • poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E03.2, its category, or a range that includes it.

Applicable To 1

These notes mention E03.2.

  • Z83.4 Family history of other endocrine, nutritional and metabolic diseases
    Conditions classifiable to E00-E07, E15-E88 names E00-E07, which includes this code

Code First 7

These codes say to code first a condition named in the note, and E03.2 is one of the conditions named.

  • G13.2 Systemic atrophy primarily affecting the central nervous system in myxedema
    hypothyroidism (E03.-) names E03.-, which includes this code
  • H28 Cataract in diseases classified elsewhere
    myxedema (E03.-) names E03.-, which includes this code
  • D63.8 Anemia in other chronic diseases classified elsewhere
    hypothyroidism (E00.0-E03.9) names E00.0-E03.9, which includes this code
  • F02 Dementia in other diseases classified elsewhere
    hypothyroidism, acquired (E00-E03.-) names E00-E03, which includes this code
  • G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
    cerebral degeneration (due to) hypothyroidism (E00.0-E03.9) names E00.0-E03.9, which includes this code
  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E00-E07, which includes this code
  • M14.8 Arthropathies in other specified diseases classified elsewhere
    hypothyroidism (E00-E03) names E00-E03, which includes this code

Code Also 1

These codes say E03.2 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • I27.29 Other secondary pulmonary hypertension
    hypothyroidism (E00-E03) names E00-E03, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END001
Thyroid disorders
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Hypothyroidism

Hypothyroidism, or underactive thyroid, happens when your thyroid gland doesn't make enough thyroid hormones to meet your body's needs.

The full article covers:

  • What is hypothyroidism?
  • What causes hypothyroidism?
  • Who is at risk for hypothyroidism?
  • What are the symptoms of hypothyroidism?
  • What other problems can hypothyroidism cause?
  • How is hypothyroidism diagnosed?
  • What are the treatments for hypothyroidism?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E03.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
244.2 Iodine hypothyroidism
Approximate The match is approximate rather than exact.
ICD-9-CM
244.3 Iatrogen hypothyroid NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E03.2Overview

What is the ICD-10 code for hypothyroidism due to medicaments and other exogenous substances?

The ICD-10-CM code for hypothyroidism due to medicaments and other exogenous substances is E03.2 (sometimes written as E032). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E03.2 (Other hypothyroidism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hypothyroidism due to medicaments and other exogenous substances on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E03.2 group to?

When hypothyroidism due to medicaments and other exogenous substances is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E03.2 be reported with E89.0?

Not as a rule. The Excludes1 note at E03, which applies to E03.2, lists "postprocedural hypothyroidism (E89.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E03.2 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after E03.2.

Does E03.2 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: E03.2 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 44 (Thyroid Disorders).