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  5. Thyrotoxicosis [hyperthyroidism] (E05)

Thyrotoxicosis [hyperthyroidism] (E05)

The ICD-10 code section E05 is used to classify thyrotoxicosis, also known as hyperthyroidism, which refers to an overactive thyroid gland producing excessive thyroid hormones. These codes help specify the exact type and severity, including whether a thyroid storm (a severe thyrotoxic crisis) is present.

This section includes detailed codes such as E05.00 for thyrotoxicosis with diffuse goiter without crisis, often referred to by synonyms like Graves' disease or toxic diffuse goiter, helping coders identify cases of classic autoimmune hyperthyroidism. Codes like E05.10 and E05.20 refer to toxic single and multinodular thyroid nodules, respectively, with options to specify the presence or absence of a thyrotoxic crisis. The E05.4X series covers thyrotoxicosis factitia, which is caused by excessive thyroid hormone intake. Other specified forms, including ectopic thyroid tissue-related thyrotoxicosis and conditions caused by iodine or medications, are under E05.8X. Lastly, unspecified thyrotoxicosis codes E05.90 and E05.91 are used when the exact type is unclear but symptoms like heart disease or crisis are noted. The inclusion of synonyms such as “thyrotoxic crisis,” “Graves' disease,” and “toxic nodular goiter” alongside the codes helps medical coders accurately select the correct ICD-10 code for hyperthyroidism cases based on clinical presentation.

  • Endocrine, nutritional and metabolic diseases (E00–E89)

    • Disorders of thyroid gland (E00-E07)

        • Thyrotoxicosis [hyperthyroidism] (E05)

        • E05 Thyrotoxicosis [hyperthyroidism]
        • E05.0 Thyrotoxicosis with diffuse goiter
        • E05.00 Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm
        • E05.01 Thyrotoxicosis with diffuse goiter with thyrotoxic crisis or storm
        • E05.1 Thyrotoxicosis with toxic single thyroid nodule
        • E05.10 Thyrotoxicosis with toxic single thyroid nodule without thyrotoxic crisis or storm
        • E05.11 Thyrotoxicosis with toxic single thyroid nodule with thyrotoxic crisis or storm
        • E05.2 Thyrotoxicosis with toxic multinodular goiter
        • E05.20 Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm
        • E05.21 Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
        • E05.3 Thyrotoxicosis from ectopic thyroid tissue
        • E05.30 Thyrotoxicosis from ectopic thyroid tissue without thyrotoxic crisis or storm
        • E05.31 Thyrotoxicosis from ectopic thyroid tissue with thyrotoxic crisis or storm
        • E05.4 Thyrotoxicosis factitia
        • E05.40 Thyrotoxicosis factitia without thyrotoxic crisis or storm
        • E05.41 Thyrotoxicosis factitia with thyrotoxic crisis or storm
        • E05.8 Other thyrotoxicosis
        • E05.80 Other thyrotoxicosis without thyrotoxic crisis or storm
        • E05.81 Other thyrotoxicosis with thyrotoxic crisis or storm
        • E05.9 Thyrotoxicosis, unspecified
        • E05.90 Thyrotoxicosis, unspecified without thyrotoxic crisis or storm
        • E05.91 Thyrotoxicosis, unspecified with thyrotoxic crisis or storm

Instructional Notations

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • chronic thyroiditis with transient thyrotoxicosis E06.2
  • neonatal thyrotoxicosis P72.1

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Graves Disease

A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).

Hyperthyroidism

Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.

Thyroid Hormone Resistance Syndrome

An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.

Thyrotoxicosis

A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous source of hormone may be thyroid HYPERPLASIA; THYROID NEOPLASMS; or hormone-producing extrathyroidal tissue. Thyrotoxicosis is characterized by NERVOUSNESS; TACHYCARDIA; FATIGUE; WEIGHT LOSS; heat intolerance; and excessive SWEATING.