2027 ICD-10-CM Diagnosis Code D61.2Aplastic anemia due to other external agents
ICD-10-CM Codes›D50–D89›D60-D64›D61
- Billable — Valid for Submission
- MCC — Major Complication or Comorbidity
- Risk Adjusts — HCC 109
- Chronic Condition
D61.2 is a billable ICD-10-CM diagnosis code for aplastic anemia due to other external agents. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 110 closely related codes. Coders also document this condition as acquired aplastic anemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia and Drug induced or toxic related condition.
For Medicare Advantage risk adjustment, D61.2 maps to CMS-HCC Category 109 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias) under the V28 model, adding a risk factor of about 1.144 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D61.2 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired aplastic anemia
- Anemia caused by ionizing radiation
- Anemia caused by physical agent
- Aplastic anemia caused by ionizing radiation
- Aplastic anemia caused by toxic cause
- Aplastic anemia due to infection
- Disorder of bone marrow caused by ionizing radiation
- Parvoviral aplastic crisis
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D61.2: its own notes plus those printed at D61 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- neutropenia (D70.-)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Code First
The underlying condition named in the note is sequenced before this code.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Aplastic Anemia
Aplastic anemia is a rare but serious blood disorder. If you have it, your bone marrow doesn't make enough new blood cells. It happens when there is damage to stem cells inside your bone marrow. There are different types of aplastic anemia, including Fanconi anemia.
The full article covers:
- What is aplastic anemia?
- What causes aplastic anemia?
- What are the symptoms of aplastic anemia?
- What other problems can aplastic anemia cause?
- How is aplastic anemia diagnosed?
- What are the treatments for aplastic anemia?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D61.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D61.2Overview
What is the ICD-10 code for aplastic anemia due to other external agents?
The ICD-10-CM code for aplastic anemia due to other external agents is D61.2 (sometimes written as D612). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D61.2 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report aplastic anemia due to other external agents on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D61.2 group to?
When aplastic anemia due to other external agents is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D61.2 a CC or MCC?
CMS lists D61.2 as an MCC (major complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 110 closely related codes in its exclusion list.
What is coded first with D61.2?
The Code First note reads: if applicable, toxic effects of substances chiefly nonmedicinal as to source (T51-T65). When one of these applies, it is sequenced before D61.2.
What HCC is D61.2?
D61.2 (aplastic anemia due to other external agents) maps to CMS-HCC Category 109 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias), commonly written as HCC 109, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 46 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 96.
Does D61.2 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D61.2 adds a risk adjustment factor of about 1.144 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.529 to 1.815 depending on the payment segment). HCC 109 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 109 category page.
