2026 ICD-10-CM Diagnosis Code D61.01Constitutional (pure) red blood cell aplasia

ICD-10-CM Codes›D50–D89›D60-D64›D61

ICD-10-CM D61.01
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D61.01 is a billable ICD-10-CM diagnosis code for constitutional (pure) red blood cell aplasia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. Coders also document this condition as acute pure red cell aplasia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia.

Code Identity

ICD-10-CM Code
D61.01
Billable Status
Yes — Valid for Submission
Code Describes
Constitutional (pure) red blood cell aplasia
Short Description
Constitutional (pure) red blood cell aplasia
Same as the full description in the CMS dataset.
Parent Code
D61.0
Constitutional aplastic anemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD60-D64Aplastic and other anemias and other bone marrow failure syndromes
CategoryD61Other aplastic anemias and other bone marrow failure syndromes
This CodeD61.01Constitutional (pure) red blood cell aplasia

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute pure red cell aplasia
  • Congenital hypoplastic anemia
  • Constitutional aplastic anemia
  • Erythroid hypoplasia of bone marrow
  • Finding of bone marrow erythropoiesis
  • Hypoplastic anemia
  • Pure red cell aplasia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Blackfan-Diamond syndrome
  • Congenital (pure) red cell aplasia
  • Familial hypoplastic anemia
  • Primary (pure) red cell aplasia
  • Red cell (pure) aplasia of infants

Type 1 Excludes

  • acquired red cell aplasia D60.9

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • aplastic
        • red cell (pure)
          • congenital
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • Diamond-Blackfan (congenital hypoplastic)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hypoplasia, red blood cells
        • congenital or familial
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • hypoplastic (idiopathic)
        • congenital or familial (of childhood)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • Joseph-Diamond-Blackfan (congenital hypoplastic)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • pure red cell
        • congenital
    • Aplasia
      • bone marrow (myeloid)
        • congenital
    • Aplasia
      • congenital pure red cell
    • Aplasia
      • erythrocyte congenital
    • Aplasia
      • red cell (with thymoma)
        • congenital
    • Aplasia
      • red cell (with thymoma)
        • constitutional
    • Aplasia
      • red cell (with thymoma)
        • hereditary
    • Aplasia
      • red cell (with thymoma)
        • of infants
    • Aplasia
      • red cell (with thymoma)
        • primary
    • Aplasia
      • red cell (with thymoma)
        • pure
    • Blackfan-Diamond anemia or syndrome(congenital hypoplastic anemia)
    • Diamond-Blackfan anemia(congenital hypoplastic)
    • Erythroblastopenia
      • congenital
    • Hypoplasia, hypoplastic
      • erythroid, congenital
    • Joseph-Diamond-Blackfan anemia(congenital hypoplastic)
    • Kaznelson's syndrome(congenital hypoplastic anemia)
    • Syndrome
      • Blackfan-Diamond
    • Syndrome
      • Diamond-Blackfan
    • Syndrome
      • Joseph-Diamond-Blackfan

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD003
Aplastic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D61.01 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
284.01 Constitution RBC aplasia
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D61.01Overview

Is D61.01 (Constitutional aplastic anemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report constitutional (pure) red blood cell aplasia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D61.01 group to?

When constitutional (pure) red blood cell aplasia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D61.01?

Under the General Equivalence Mappings, constitutional (pure) red blood cell aplasia converts to ICD-9-CM 284.01 (constitution RBC aplasia). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.