2027 ICD-10-CM Diagnosis Code D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

Billable — Valid for Submission
Not Chronic

ICD-10-CM D48.2

CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D48.2 is a billable ICD-10-CM diagnosis code for neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 564 through 566. Coders also document this condition as neoplasm of uncertain behavior of autonomic nervous system. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code

D48.2

Billable Status

Yes — Valid for Submission

Code Describes

Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

Short Description

Neoplm of uncrt behav of prph nerves and autonm nervous sys

Parent Code

D48

Neoplasm of uncertain behavior of other and unspecified sites

Code Classification

ChapterC00–D49Neoplasms

SectionD37-D48Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

CategoryD48Neoplasm of uncertain behavior of other and unspecified sites

This CodeD48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

Neoplasm of uncertain behavior of autonomic nervous system
Neoplasm of uncertain behavior of peripheral nerve
Neoplasm of uncertain behavior of peripheral nerves and peripheral autonomic nervous system

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D48.2: its own notes plus those printed at D48, block D37-D48, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On D48.2 itself

neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)

From D48 Neoplasm of uncertain behavior of other and unspecified sites applies to 21 codes

neurofibromatosis (nonmalignant) (Q85.0-)

From Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes applies to 137 codes

neoplasms of unspecified behavior (D49.-)

Notes

General instructions on how these codes are used.

From Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes applies to 137 codes

Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes

Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D48.2, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming D48.2: they are not reported together with it, unless the two conditions are unrelated.

D43 Neoplasm of uncertain behavior of brain and central nervous system
neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)

Excludes2 1

These codes carry an Excludes2 note naming D48.2: its condition is not part of those codes, and both may be reported when the patient has both.

D49 Neoplasms of unspecified behavior
neoplasms of uncertain behavior (D37-D44, D48) names D48, which includes this code

Notes 1

These notes mention D48.2.

Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. names D48, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072

Neoplasms of unspecified nature or uncertain behavior

Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

Filter table of neoplasms:

Site	Malig. Primary	Malig. Secondary	Ca in situ	Benign	Uncertain	Unspec.
brachial plexus	C47.1	C79.89	–	D36.12	D48.2	D49.2
ganglia [See Also: Neoplasm, nerve, peripheral]	C47.9	C79.89	–	D36.10	D48.2	D49.2
lumbosacral plexus	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion)	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › autonomic NEC [See Also: Neoplasm, nerve, peripheral]	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › brachial	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › femoral	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › ganglion NEC [See Also: Neoplasm, nerve, peripheral]	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › intercostal	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › lumbar	C47.6	C79.89	–	D36.17	D48.2	D49.2
nerve (ganglion) › median	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › obturator	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › parasympathetic NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › peripheral NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › peripheral NEC › abdomen	C47.4	C79.89	–	D36.15	D48.2	D49.2
nerve (ganglion) › peripheral NEC › abdominal wall	C47.4	C79.89	–	D36.15	D48.2	D49.2
nerve (ganglion) › peripheral NEC › ankle	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › antecubital fossa or space	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › arm	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › auricle (ear)	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › axilla	C47.3	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › back	C47.6	C79.89	–	D36.17	D48.2	D49.2
nerve (ganglion) › peripheral NEC › buttock	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › calf	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › cervical region	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › cheek	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › chest (wall)	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › chin	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › ear (external)	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › elbow	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › extrarectal	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › extremity	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › peripheral NEC › extremity › lower	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › extremity › upper	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › eyelid	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › face	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › finger	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › flank	C47.6	C79.89	–	D36.17	D48.2	D49.2
nerve (ganglion) › peripheral NEC › foot	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › forearm	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › forehead	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › gluteal region	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › groin	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › hand	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › head	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › heel	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › hip	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › infraclavicular region	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › inguinal (canal) (region)	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › intrathoracic	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › ischiorectal fossa	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › knee	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › leg	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › limb NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › peripheral NEC › limb NEC › lower	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › limb NEC › upper	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › nates	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › neck	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › pararectal	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › paraurethral	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › paravaginal	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › pelvis (floor)	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › pelvoabdominal	C47.8	C79.89	–	D36.17	D48.2	D49.2
nerve (ganglion) › peripheral NEC › perineum	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › perirectal (tissue)	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › periurethral (tissue)	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › popliteal fossa or space	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › presacral	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › pterygoid fossa	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › rectovaginal septum or wall	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › rectovesical	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › sacrococcygeal region	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › scalp	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › scapular region	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › shoulder	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › submental	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › supraclavicular region	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › temple	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › temporal region	C47.0	C79.89	–	D36.11	D48.2	D49.2
nerve (ganglion) › peripheral NEC › thigh	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › thoracic (duct) (wall)	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › thorax	C47.3	C79.89	–	D36.14	D48.2	D49.2
nerve (ganglion) › peripheral NEC › thumb	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › peripheral NEC › toe	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › peripheral NEC › trunk	C47.6	C79.89	–	D36.17	D48.2	D49.2
nerve (ganglion) › peripheral NEC › umbilicus	C47.4	C79.89	–	D36.15	D48.2	D49.2
nerve (ganglion) › peripheral NEC › vesicorectal	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › peripheral NEC › wrist	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › radial	C47.1	C79.89	–	D36.12	D48.2	D49.2
nerve (ganglion) › sacral	C47.5	C79.89	–	D36.16	D48.2	D49.2
nerve (ganglion) › sciatic	C47.2	C79.89	–	D36.13	D48.2	D49.2
nerve (ganglion) › spinal NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › sympathetic NEC [See Also: Neoplasm, nerve, peripheral]	C47.9	C79.89	–	D36.10	D48.2	D49.2
nerve (ganglion) › ulnar	C47.1	C79.89	–	D36.12	D48.2	D49.2
peripheral nerve NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2
plexus › brachial	C47.1	C79.89	–	D36.12	D48.2	D49.2
plexus › cervical	C47.0	C79.89	–	D36.11	D48.2	D49.2
plexus › lumbosacral	C47.5	C79.89	–	D36.16	D48.2	D49.2
plexus › sacral	C47.5	C79.89	–	D36.16	D48.2	D49.2
sciatic nerve	C47.2	C79.89	–	D36.13	D48.2	D49.2
spine, spinal (column) › nerve (root)	C47.9	C79.89	–	D36.10	D48.2	D49.2
spine, spinal (column) › root	C47.9	C79.89	–	D36.10	D48.2	D49.2
sympathetic nerve or nervous system NEC	C47.9	C79.89	–	D36.10	D48.2	D49.2

Patient EducationClinical

Autonomic Nervous System Disorders

Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D48.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM

238.1 Unc behav neo soft tissu

Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.

FY 2017–2026No changes

FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D48.2Overview

Is D48.2 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D48.2 group to?

When neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system is the principal diagnosis on an inpatient stay, it groups to MS-DRG 564, 566, 565, with relative weights from 0.7374 to 1.4909 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D48.2 be reported with D48.7?

Not as a rule. The Excludes1 note on D48.2 lists "neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of D48.2?

Under the General Equivalence Mappings, neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system converts to ICD-9-CM 238.1 (unc behav neo soft tissu). The mapping is approximate, so confirm the match fits the documentation.

Indicator	Meaning	CMS pays CC/MCC DRG
Y	Diagnosis was present at the time of inpatient admission	Yes
N	Diagnosis was not present at the time of admission	No
U	Documentation is insufficient to determine	No
W	Clinically undetermined	Yes
1	Unreported, exempt from POA reporting	No