2026 ICD-10-CM Diagnosis Code D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

AHRQ’s CCSR groups this code into broader clinical categories.

• Brachial Plexus

  the large network of nerve fibers which distributes the innervation of the upper extremity. the brachial plexus extends from the neck into the axilla. in humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (c5-c8 and t1), but variations are not uncommon.

• Brachial Plexus Block

  a blocking of neural conduction in the network of nerve fibers innervating the upper extremity.

• Brachial Plexus Neuritis

  a syndrome associated with inflammation of the brachial plexus. clinical features include severe pain in the shoulder region which may be accompanied by muscle weakness and loss of sensation in the upper extremity. this condition may be associated with virus diseases; immunization; surgery; heroin use (see heroin dependence); and other conditions. the term brachial neuralgia generally refers to pain associated with brachial plexus injury. (from adams et al., principles of neurology, 6th ed, pp1355-6)

• Brachial Plexus Neuropathies

  diseases of the cervical (and first thoracic) roots, nerve trunks, cords, and peripheral nerve components of the brachial plexus. clinical manifestations include regional pain, paresthesia; muscle weakness, and decreased sensation (hypesthesia) in the upper extremity. these disorders may be associated with trauma (including birth injuries); thoracic outlet syndrome; neoplasms; neuritis; radiotherapy; and other conditions. (from adams et al., principles of neurology, 6th ed, pp1351-2)

• Lumbosacral Plexus

  the lumbar and sacral plexuses taken together. the fibers of the lumbosacral plexus originate in the lumbar and upper sacral spinal cord (l1 to s3) and innervate the lower extremities.

• Sciatic Nerve

  a nerve which originates in the lumbar and sacral spinal cord (l4 to s3) and supplies motor and sensory innervation to the lower extremity. the sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. it has two major branches, the tibial nerve and the peroneal nerve.

• Sciatic Neuropathy

  disease or damage involving the sciatic nerve, which divides into the peroneal nerve and tibial nerve (see also peroneal neuropathies and tibial neuropathy). clinical manifestations may include sciatica or pain localized to the hip, paresis or paralysis of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. the sciatic nerve may be affected by trauma; ischemia; collagen diseases; and other conditions. (from adams et al., principles of neurology, 6th ed, p1363)

Anatomical sites in the Table of Neoplasms that reference this code family.

Autonomic Nervous System Disorders

Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including:

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