2027 ICD-10-CM Diagnosis Code C94.40Acute panmyelosis with myelofibrosis not having achieved remission
ICD-10-CM Codes›C00–D49›C81-C96›C94
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 17
- Chronic Condition
C94.40 is a billable ICD-10-CM diagnosis code for acute panmyelosis with myelofibrosis not having achieved remission. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 820 through 822, 834 through 839, 850. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 133 closely related codes. Coders also document this condition as acute panmyelosis with myelofibrosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Leukemia - all other types.
For Medicare Advantage risk adjustment, C94.40 maps to CMS-HCC Category 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) under the V28 model, adding a risk factor of about 4.209 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C94.40 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acute panmyelosis with myelofibrosis
- Myelofibrosis
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C94.40: its own notes plus those printed at C94.4, C94, block C81-C96, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Acute myelofibrosis NOS
- Acute panmyelosis with myelofibrosis with failed remission
- Acute panmyelosis NOS
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C94.40, its category, or a range that includes it.
Applicable To 2
These notes mention C94.40.
Excludes1 6
These codes carry an Excludes1 note naming C94.40: they are not reported together with it, unless the two conditions are unrelated.
- D47.4 Osteomyelofibrosisacute myelofibrosis (C94.4-) names C94.4-, which includes this code
- D72.825 Bandemialeukemia (C91.-, C92.-, C93.-, C94.-, C95.-) names C94.-, which includes this code
- D75.81 Myelofibrosisacute myelofibrosis (C94.4-) names C94.4-, which includes this code
- D72.8 Other specified disorders of white blood cells
- T66 Radiation sickness, unspecified
- Z85.6 Personal history of leukemia
Code First 3
These codes say to code first a condition named in the note, and C94.40 is one of the conditions named.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acute Panmyelosis with Myelofibrosis
an acute myeloid leukemia characterized by bone marrow fibrosis without preexisting primary myelofibrosis.
Patient EducationClinical
Bone Marrow Diseases
Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C94.40 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C94.40Overview
What is the ICD-10 code for acute panmyelosis with myelofibrosis not having achieved remission?
The ICD-10-CM code for acute panmyelosis with myelofibrosis not having achieved remission is C94.40 (sometimes written as C9440). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C94.40 (Acute panmyelosis with myelofibrosis) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report acute panmyelosis with myelofibrosis not having achieved remission on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C94.40 group to?
When acute panmyelosis with myelofibrosis not having achieved remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 834, 837, 821, 822, 836, 839, 838, 850, 835, 820, with relative weights from 1.1267 to 8.4076 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C94.40 a CC or MCC?
CMS lists C94.40 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 133 closely related codes in its exclusion list.
Can C94.40 be reported with D75.81?
Not as a rule. The Excludes1 note at C94.4, which applies to C94.40, lists "myelofibrosis NOS (D75.81)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is C94.40?
C94.40 (acute panmyelosis with myelofibrosis not having achieved remission) maps to CMS-HCC Category 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic), commonly written as HCC 17, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 8 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 19.
Does C94.40 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C94.40 adds a risk adjustment factor of about 4.209 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 1.952 to 4.235 depending on the payment segment). HCC 17 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 17 category page.
