ICD-10-CM Code C91.0

Acute lymphoblastic leukemia [ALL]

Version 2021 Non-Billable Code

Not Valid for Submission

C91.0 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of acute lymphoblastic leukemia [all]. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

Short Description:Acute lymphoblastic leukemia [ALL]
Long Description:Acute lymphoblastic leukemia [ALL]

Consider the following ICD-10 codes with a higher level of specificity:

  • C91.00 - Acute lymphoblastic leukemia not having achieved remission
  • C91.01 - Acute lymphoblastic leukemia, in remission
  • C91.02 - Acute lymphoblastic leukemia, in relapse

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code C91.0:

  • Codes in subcategory C91.0- should only be used for T-cell and B-cell precursor leukemia

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C91.0 are found in the index:

Clinical Information

  • MYELOID LYMPHOID LEUKEMIA PROTEIN-. myeloid lymphoid leukemia protein is a transcription factor that maintains high levels of homeotic gene expression during development. the gene for myeloid lymphoid leukemia protein is commonly disrupted in leukemia and combines with over 40 partner genes to form fusion oncogene proteins.
  • ADP RIBOSYL CYCLASE 1-. a bifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic adp ribose cadpr from nad+ to adp ribose. it is a cell surface molecule which is predominantly expressed on lymphoid cells and myeloid cells.
  • PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA LYMPHOMA-. a neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. it is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
      • Lymphoid leukemia (C91)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Acute Lymphocytic Leukemia

Also called: ALL, Acute lymphoblastic leukemia

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children.

Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70.

Symptoms of ALL include:

  • Weakness or feeling tired
  • Fever
  • Easy bruising or bleeding
  • Bleeding under the skin
  • Shortness of breath
  • Weight loss or loss of appetite
  • Pain in the bones or stomach
  • Pain or a feeling of fullness below the ribs
  • Painless lumps in the neck, underarm, stomach, or groin

Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back.

NIH: National Cancer Institute

  • Acute lymphocytic leukemia (ALL) (Medical Encyclopedia)
  • After chemotherapy - discharge (Medical Encyclopedia)
  • Bone marrow transplant (Medical Encyclopedia)
  • Bone marrow transplant - discharge (Medical Encyclopedia)

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