2022 ICD-10-CM Code C91.0

Acute lymphoblastic leukemia [ALL]

Version 2021

Not Valid for Submission

ICD-10:C91.0
Short Description:Acute lymphoblastic leukemia [ALL]
Long Description:Acute lymphoblastic leukemia [ALL]

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
      • Lymphoid leukemia (C91)

C91.0 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of acute lymphoblastic leukemia [all]. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Acute lymphoblastic leukemia [ALL]

Non-specific codes like C91.0 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for acute lymphoblastic leukemia [all]:

  • BILLABLE CODE - Use C91.00 for Acute lymphoblastic leukemia not having achieved remission
  • BILLABLE CODE - Use C91.01 for Acute lymphoblastic leukemia, in remission
  • BILLABLE CODE - Use C91.02 for Acute lymphoblastic leukemia, in relapse

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code C91.0:


Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C91.0 are found in the index:

Clinical Information

Information for Patients


Acute Lymphocytic Leukemia

What is leukemia?

Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job:

When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.

What is acute lymphocytic leukemia (ALL)?

Acute lymphocytic leukemia is a type of acute leukemia. It's also called ALL and acute lymphoblastic leukemia. "Acute" means that it usually gets worse quickly if it's not treated. ALL is the most common type of cancer in children. It can also affect adults.

In ALL, the bone marrow makes too many lymphocytes, a type of white blood cell. These cells normally help your body fight infection. But in ALL, they are abnormal and cannot fight infection very well. They also crowd out the healthy cells, which can lead to infection, anemia, and easy bleeding. These abnormal cells can also spread to other parts of the body, including the brain and spinal cord.

What causes acute lymphocytic leukemia (ALL)?

ALL happens when there are changes in the genetic material (DNA) in bone marrow cells. The cause of these genetic changes is unknown. However, there are certain factors that raise your risk of ALL.

Who is at risk for acute lymphocytic leukemia (ALL)?

The factors that raise your risk of ALL include

What are the symptoms of acute lymphocytic leukemia (ALL)?

The signs and symptoms of ALL include

How is acute lymphocytic leukemia (ALL) diagnosed?

Your health care provider may use many tools to diagnose ALL and figure out which subtype you have:

If you are diagnosed with ALL, you may have additional tests to see whether the cancer has spread. These include imaging tests and a lumbar puncture, which is a procedure to collect and test cerebrospinal fluid (CSF).

What are the treatments for acute lymphocytic leukemia (ALL)?

Treatments for ALL include

Treatment is usually done in two phases:

Treatment during both phases also usually includes central nervous system (CNS) prophylaxis therapy. This therapy helps prevent the spread of leukemia cells to the brain and spinal cord. It may be high dose chemotherapy or chemotherapy injected into the spinal cord. It also sometimes includes radiation therapy.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Leukemia-Patient Version Learn about acute lymphoblastic leukemia risk factors, symptoms, tests to diagnose, factors affecting prognosis, and treatment.
[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)