2027 ICD-10-CM Diagnosis Code C78.89Secondary malignant neoplasm of other digestive organs
ICD-10-CM Codes›C00–D49›C76-C80›C78
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 17
- Chronic Condition
C78.89 is a billable ICD-10-CM diagnosis code for secondary malignant neoplasm of other digestive organs. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 374 through 376. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 27 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Secondary malignancies.
For Medicare Advantage risk adjustment, C78.89 maps to CMS-HCC Category 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic) under the V28 model, adding a risk factor of about 4.209 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C78.89 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acinar cell carcinoma of pancreas
- Cystadenocarcinoma of pancreas
- Lymphoma finding
- Lymphoma involves spleen
- Malignant melanoma metastatic to pancreas
- Malignant neoplasm of ampulla of Vater
- Malignant neoplasm of body of pancreas
- Malignant neoplasm of cardio-esophageal junction of stomach
- Malignant neoplasm of cervical esophagus
- Malignant neoplasm of exocrine pancreas
- Malignant neoplasm of fundus of stomach
- Malignant neoplasm of greater curvature of stomach
- Malignant neoplasm of head of pancreas
- Malignant neoplasm of lesser curvature of stomach
- Malignant neoplasm of middle third of esophagus
- Malignant neoplasm of pyloric antrum
- Malignant neoplasm of pylorus of stomach
- Malignant neoplasm of tail of pancreas
- Malignant neoplasm of tonsil
- Malignant neoplasm of tonsillar fossa
- Metastatic acinar cell carcinoma to pancreas
- Metastatic adenocarcinoma to pancreatic duct
- Metastatic carcinoma to abdominal part of esophagus
- Metastatic carcinoma to ampulla of Vater
- Metastatic carcinoma to biliary tract
- Metastatic carcinoma to body of pancreas
- Metastatic carcinoma to body of stomach
- Metastatic carcinoma to cardia of stomach
- Metastatic carcinoma to cervical part of esophagus
- Metastatic carcinoma to common bile duct
- Metastatic carcinoma to duodenum
- Metastatic carcinoma to endocrine pancreas
- Metastatic carcinoma to extrahepatic bile duct
- Metastatic carcinoma to fundus of stomach
- Metastatic carcinoma to gallbladder
- Metastatic carcinoma to gallbladder and extrahepatic biliary tract
- Metastatic carcinoma to greater curve of stomach
- Metastatic carcinoma to head of pancreas
- Metastatic carcinoma to lesser curve of stomach
- Metastatic carcinoma to lower third of esophagus
- Metastatic carcinoma to middle third of esophagus
- Metastatic carcinoma to pancreas
- Metastatic carcinoma to pyloric antrum
- Metastatic carcinoma to pylorus
- Metastatic carcinoma to stomach
- Metastatic carcinoma to tail of pancreas
- Metastatic carcinoma to thoracic part of esophagus
- Metastatic carcinoma to upper third of esophagus
- Metastatic cystadenocarcinoma to pancreas
- Metastatic HER2 positive gastroesophageal junction cancer
- Metastatic infiltrating duct carcinoma to pancreas
- Metastatic malignant melanoma to digestive organ
- Metastatic malignant neoplasm to abdominal esophagus
- Metastatic malignant neoplasm to ampulla of Vater
- Metastatic malignant neoplasm to biliary tract
- Metastatic malignant neoplasm to body of pancreas
- Metastatic malignant neoplasm to body of stomach
- Metastatic malignant neoplasm to cardia of stomach
- Metastatic malignant neoplasm to cervical esophagus
- Metastatic malignant neoplasm to common bile duct
- Metastatic malignant neoplasm to cystic duct
- Metastatic malignant neoplasm to diaphragm
- Metastatic malignant neoplasm to duodenum
- Metastatic malignant neoplasm to esophagus
- Metastatic malignant neoplasm to extrahepatic bile ducts
- Metastatic malignant neoplasm to fundus of stomach
- Metastatic malignant neoplasm to gallbladder
- Metastatic malignant neoplasm to gastrointestinal tract
- Metastatic malignant neoplasm to greater curvature of stomach
- Metastatic malignant neoplasm to head of pancreas
- Metastatic malignant neoplasm to intestinal tract
- Metastatic malignant neoplasm to islets of Langerhans
- Metastatic malignant neoplasm to lateral wall of oropharynx
- Metastatic malignant neoplasm to lesser curvature of stomach
- Metastatic malignant neoplasm to lower third of esophagus
- Metastatic malignant neoplasm to middle third of esophagus
- Metastatic malignant neoplasm to muscle of abdomen
- Metastatic malignant neoplasm to muscle of thorax
- Metastatic malignant neoplasm to muscle of trunk
- Metastatic malignant neoplasm to pancreas
- Metastatic malignant neoplasm to pancreatic duct
- Metastatic malignant neoplasm to pyloric antrum
- Metastatic malignant neoplasm to pylorus
- Metastatic malignant neoplasm to respiratory and digestive systems
- Metastatic malignant neoplasm to small intestine
- Metastatic malignant neoplasm to spleen
- Metastatic malignant neoplasm to stomach
- Metastatic malignant neoplasm to tail of pancreas
- Metastatic malignant neoplasm to thoracic esophagus
- Metastatic malignant neoplasm to tonsil
- Metastatic malignant neoplasm to tonsillar fossa
- Metastatic malignant neoplasm to upper third of esophagus
- Metastatic malignant neoplasm to Waldeyer's ring
- Metastatic mucinous cystadenocarcinoma to pancreas
- Metastatic squamous cell carcinoma to stomach
- Metastatic undifferentiated carcinoma to esophagus
- Metastatic undifferentiated carcinoma to stomach
- Mucinous cystadenocarcinoma of pancreas
- Neoplasm of body of pancreas
- Neoplasm of cystic duct
- Neoplasm of diaphragm
- Neoplasm of exocrine pancreas
- Neoplasm of head of pancreas
- Neoplasm of muscle of abdomen
- Neoplasm of muscle of thorax
- Neoplasm of tail of pancreas
- Neoplasm of tonsillar fossa
- Pancreatic ductal adenocarcinoma
- Secondary carcinoma of gastrointestinal tract
- Squamous cell carcinoma of stomach
- Tumor invades beyond pancreatic capsule to adjacent structures AND/OR organs
- Tumor invades beyond pancreatic capsule to bile duct
- Tumor invades beyond pancreatic capsule to spleen
- Tumor invades beyond pancreatic capsule to stomach
- Undifferentiated carcinoma of esophagus
- Undifferentiated carcinoma of stomach
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C78.89: its own notes plus those printed at C78 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
- exocrine pancreatic insufficiency (K86.81)
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C78.89, its category, or a range that includes it.
Applicable To 2
These notes mention C78.89.
Excludes2 1
These codes carry an Excludes2 note naming C78.89: its condition is not part of those codes, and both may be reported when the patient has both.
- Block C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissuesecondary neoplasm of spleen (C78.89)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| ampulla of Vater | C24.1 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| antrum (Highmore) (maxillary) › pyloric | C16.3 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| bile or biliary (tract) | C24.9 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| bile or biliary (tract) › canals, interlobular | C22.1 | C78.89 | D01.5 | D13.4 | D37.6 | D49.0 |
| bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › interlobular | C22.1 | C78.89 | D01.5 | D13.4 | D37.6 | D49.0 |
| bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › intrahepatic › and extrahepatic | C24.8 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| cardia (gastric) | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| cardiac orifice (stomach) | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| cardio-esophageal junction | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| cardio-esophagus | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| cholangiole | C22.1 | C78.89 | D01.5 | D13.4 | D37.6 | D49.0 |
| choledochal duct | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| common (bile) duct | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| corpus › gastric | C16.2 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| cystic (bile) duct (common) | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| digestive organs, system, tube, or tract NEC | C26.9 | C78.89 | D01.9 | D13.99 | D37.9 | D49.0 |
| esophagogastric junction | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| esophagus | C15.9 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › abdominal | C15.5 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › cervical | C15.3 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › distal (third) | C15.5 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › lower (third) | C15.5 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › middle (third) | C15.4 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › proximal (third) | C15.3 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › thoracic | C15.4 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| esophagus › upper (third) | C15.3 | C78.89 | D00.1 | D13.0 | D37.8 | D49.0 |
| extrahepatic (bile) duct | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| fundus › stomach | C16.1 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| gall duct (extrahepatic) | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| gallbladder | C23 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| gastrocolic | C26.9 | C78.89 | D01.9 | D13.99 | D37.9 | D49.0 |
| gastroesophageal junction | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| gastrointestinal (tract) NEC | C26.9 | C78.89 | D01.9 | D13.99 | D37.9 | D49.0 |
| hepatic [See Also: Index to disease, by histology] › duct (bile) | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| hepatobiliary | C24.9 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| insular tissue (pancreas) | C25.4 | C78.89 | D01.7 | D13.7 | D37.8 | D49.0 |
| intestine, intestinal › tract NEC | C26.0 | C78.89 | D01.40 | D13.99 | D37.8 | D49.0 |
| islands or islets of Langerhans | C25.4 | C78.89 | D01.7 | D13.7 | D37.8 | D49.0 |
| junction › cardioesophageal | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| junction › esophagogastric | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| junction › gastroesophageal | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| Langerhans, islands or islets | C25.4 | C78.89 | D01.7 | D13.7 | D37.8 | D49.0 |
| pancreas | C25.9 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| pancreas › body | C25.1 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| pancreas › duct (of Santorini) (of Wirsung) | C25.3 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| pancreas › ectopic tissue | C25.7 | C78.89 | – | D13.6 | D37.8 | D49.0 |
| pancreas › head | C25.0 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| pancreas › islet cells | C25.4 | C78.89 | D01.7 | D13.7 | D37.8 | D49.0 |
| pancreas › neck | C25.7 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| pancreas › tail | C25.2 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| prepylorus | C16.4 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| pyloric › antrum | C16.3 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| pyloric › canal | C16.4 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| pylorus | C16.4 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| Santorini's duct | C25.3 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
| sphincter › of Oddi | C24.0 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| spleen, splenic NEC | C26.1 | C78.89 | D01.7 | D13.99 | D37.8 | D49.0 |
| stomach | C16.9 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › antrum (pyloric) | C16.3 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › body | C16.2 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › cardia | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › cardiac orifice | C16.0 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › corpus | C16.2 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › fundus | C16.1 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › greater curvature NEC | C16.6 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › lesser curvature NEC | C16.5 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › prepylorus | C16.4 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › pylorus | C16.4 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › wall NEC | C16.9 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › wall NEC › anterior NEC | C16.8 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| stomach › wall NEC › posterior NEC | C16.8 | C78.89 | D00.2 | D13.1 | D37.1 | D49.0 |
| Vater's ampulla | C24.1 | C78.89 | D01.5 | D13.5 | D37.6 | D49.0 |
| Wirsung's duct | C25.3 | C78.89 | D01.7 | D13.6 | D37.8 | D49.0 |
Patient EducationClinical
Cancer
Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should.
The full article covers:
- What is cancer?
- What are the types of cancer?
- How does cancer develop?
- What are the symptoms of cancer?
- How is cancer diagnosed?
- What are the treatments for cancer?
- Can cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C78.89 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C78.89Overview
What is the ICD-10 code for secondary malignant neoplasm of other digestive organs?
The ICD-10-CM code for secondary malignant neoplasm of other digestive organs is C78.89 (sometimes written as C7889). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C78.89 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report secondary malignant neoplasm of other digestive organs on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C78.89 group to?
When secondary malignant neoplasm of other digestive organs is the principal diagnosis on an inpatient stay, it groups to MS-DRG 375, 374, 376, with relative weights from 0.8925 to 2.1101 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C78.89 a CC or MCC?
CMS lists C78.89 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 27 closely related codes in its exclusion list.
Can C78.89 be reported with C7B.02?
Not as a rule. The Excludes1 note at C78, which applies to C78.89, lists "secondary carcinoid tumors of liver (C7B.02)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is C78.89?
C78.89 (secondary malignant neoplasm of other digestive organs) maps to CMS-HCC Category 17 (Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic), commonly written as HCC 17, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 8 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 18.
Does C78.89 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C78.89 adds a risk adjustment factor of about 4.209 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 1.952 to 4.235 depending on the payment segment). HCC 17 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 17 category page.
